Lipoprotein a and aortic dilations

Lp(a) is something you from the first year of your life and constant after that so this is interesting.

If it wasn't for my Lp(a), my AA might not have been found. Got the blood test because my blood pressure was always low, my cholesterol mostly good but triglycerides where all over the place. So they recommend a drug to go on and I wasn't sure. As part of the prescreening they had me do a CT and bam...my AA journey began.

Makes me wonder how much Lp(a) might actually play in AA risk.

That’s interesting. My husband has elevated LP(a)… never knew there might be a connection.

My husband also has an elevated lp(a). He is on Repatha. He also has an aneurysm that seems to be stable at 4.9 cm. (The aneurysm was first seen in 2007 and measured 4.3 on a CT - and it was considered "okay" for his height and weight. I will never understand this.)
Fast forward to 2021 and it was measured at 4.8-4.9. A new cardiologist that ordered an echo found the aneurysm. What a shocker. We had paid no attention to the 4.3 cm on the 2007 CT scan - we did not remember it and have no idea why that CT was done.
Lp(a), of course, forms plaques in the arteries resulting in more stress for the heart and the aorta to circulate and plump that blood. Lp(a) was found in 2003 but outside of that being on the lab sheet, his cardiologist never breathed a word about the implications. Unbelievable.
There appears to be a family history of aneurysms. A first cousin had a mid level aortic aneurysm that dissected. He died but was resuscitated. An additional descending aneurysm at 5.0 has been found and there are also aneurysms now in his groin. This cousin's father had some sort of aneurysm that dissected; he died from it. His sister, my husband's mother, died of strokes in her brain. She had large cell vasculitis - giant cell arteritis.
My husband appears to have no vasculitis on PET scans. He went through the genetic testing and no issues were found. However, the genetic testing basically seems to screen for Marfans syndrome. He also had an intensive physical and no connective tissue disorders were found.
My husband's doctors have urged us to have all first degree relatives screened for lp(a) and also aortic aneurysms. We have sent the information but no one seems to take heed. Their doctors are totally apathetic and unaware.

I have a 4.9 ascending aneurysm. I had my Lp(a) tested and it’s s high. It’s not really high, but still high.
I sent the results to my doctor and I believe they were stuck in my folder never to be seen again.. I am on Rosuvastatin, but does that help with high Lp(a)?

To my understand, no drugs or treatments will change lp(a). They can only treat what lp(a) can affect which is of "...increasing risk of heart attack, stroke, aortic stenosis and peripheral artery disease" (https://www.heart.org/en/health-topics/cholesterol/genetic-conditions/lipoprotein-a-risks) . So the statin is to help reduce the other issues like cholesterol or blood pressure etc that co-factors that increase risk.

Short: No treatment for Lp(a), only can treat other potential factors that compound Lp(a) risks

Rouvastatin will lower your LDL-C and that, in turn, will reduce your lp(a)
My husband is on a P9SCK (sp?) med that has reduced his LDL-C to 35 and his lp(a) to 99 (from 160. Hopefully, some plaque will come off his walls.

Currently, there is no FDA approved drug to lower lp(a). However, six drugs are in clinical trials and I have heard at least a couple are highly effective.
Reducing your LDL-C dramatically - below 50 - will often reduce your lp(a). My husband has reduced his by more than a third with a PSKC9 drug.

I am no doctor but your results on that first page look good. HgbA1C and kidney function look great.
Your lp(a) is about the typical reference value of 75. I suspect you can bring that to normal by aggressively reducing your LDL-C.

Thank you!!