How long do Lupron side effects last after treatment concludes?

Posted by jbuuck @jonbuuck, May 10, 2021

I've been on Lupron for two years. The treatments have ended. How long do the side effects last? Thanks for any insight you can provide.

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@eldorado80

Started with Lupron Depot injection followed by 20 radiation sessions in 2023. Was administered the maximum 6 month 45mg dosage. Had Gleason score of 8 intermediate high risk. PSA 15. Cancer confined in Prostate with possible microscopic in lymph nodes. Radiation attacked both areas. After treatment early December PSA reading was full remission. However, since taking the LD injection I have been diagnosed with Bradycardia (slow pulse rate) and irregular heart beat so decided to stop the LD injections (4 total over 2 years was plan) in the hope that my heart will return to normal. My radiologist is in agreement that I stop. Most side effects were from injection include hot flashes, libido loss, testicular shrinkage, man boobs and others possibly caused by the injection. Side effect from radiation is incontinence while standing urinating at times. I am hopeful all will go away over the next 6-18 months. I am 80 and feel fine, My best to all posting here.

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Update:
I decided to get a baseline testosterone reading going forward now that I have decided not to take the 3 (out of 4) additional Lupron Depot therapy injections. The results just out < 20 Total T so have my work cut out for me. Normal is
I have/am experiencing all of the following side effects I’m optimistic that with diet and exercise over time T will return to normal range. Normal is approx +150-800 for a male my age.

In males, lower testosterone levels can lead to:

hair loss
a reduction in muscle tone
more fragile skin
a reduced sex drive
mood disturbances
memory or concentration problems

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