1. < Transplants

Joint pain

Posted by footballmum @footballmum, 5 days ago

Good morning

I'm 3.5 years post liver transplant. I've been experiencing quite a bit of joint pain. Particularly in my lower back, hip, elbows, left shoulder, feet and hands. Has anyone else experienced this? I'm going to see my family Dr but curious if anyone else knows if it's a tacrolimus side effect.
Thank you 💗

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8899 | @8899 | 5 days ago

I am 10 months post liver transplant and within the last 2 months I have started experiencing the same conditions. ""Especially in my hands"". I can barely open a twist off jar anymore and it wasn't an issue before a couple months ago. I started to look into it and there are a couple possibilities. (info from my Ins carrier support team) First and foremost, I was told that the Fluconazol (Diflucan) can have an overpowering interaction with the Tacrolimus. It was suggested to talk with the Doctor and maybe decrease the amount of Fluconazol I take daily. They said that the Fluconazol can decrease the effectiveness of the Tacrolimus allowing several possible side effects to be more pronounced. Right now I'm on 200mg Fluconazole in the morning and 1mg Tactrillimus in the morning and .5mg Tacrolimus in the evening. Secondly, I was told to check and then keep track of the manufacturer of the medications I'm taking. Apparently, some drug stores will give you the same drug although they might switch it out with a different manufacturer. I was told you can ask the drug store to check into that and confirm. I haven't looked into either yet as I just got this information yesterday. But I do plan to look into both.

REPLY
2 replies
footballmum | @footballmum | 4 days ago
In reply to @8899 "I am 10 months post liver transplant and within the last 2 months I have started..." + (show)
@8899

I am 10 months post liver transplant and within the last 2 months I have started experiencing the same conditions. ""Especially in my hands"". I can barely open a twist off jar anymore and it wasn't an issue before a couple months ago. I started to look into it and there are a couple possibilities. (info from my Ins carrier support team) First and foremost, I was told that the Fluconazol (Diflucan) can have an overpowering interaction with the Tacrolimus. It was suggested to talk with the Doctor and maybe decrease the amount of Fluconazol I take daily. They said that the Fluconazol can decrease the effectiveness of the Tacrolimus allowing several possible side effects to be more pronounced. Right now I'm on 200mg Fluconazole in the morning and 1mg Tactrillimus in the morning and .5mg Tacrolimus in the evening. Secondly, I was told to check and then keep track of the manufacturer of the medications I'm taking. Apparently, some drug stores will give you the same drug although they might switch it out with a different manufacturer. I was told you can ask the drug store to check into that and confirm. I haven't looked into either yet as I just got this information yesterday. But I do plan to look into both.

Jump to this post

Thank you for your response

I only take 2 mg tacrolimus 2x's per day. And ursidiol for my liver disease.

REPLY
Mentor
Cheryl, Volunteer Mentor | @cehunt57 | 4 days ago
In reply to @8899 "I am 10 months post liver transplant and within the last 2 months I have started..." + (show)
@8899

I am 10 months post liver transplant and within the last 2 months I have started experiencing the same conditions. ""Especially in my hands"". I can barely open a twist off jar anymore and it wasn't an issue before a couple months ago. I started to look into it and there are a couple possibilities. (info from my Ins carrier support team) First and foremost, I was told that the Fluconazol (Diflucan) can have an overpowering interaction with the Tacrolimus. It was suggested to talk with the Doctor and maybe decrease the amount of Fluconazol I take daily. They said that the Fluconazol can decrease the effectiveness of the Tacrolimus allowing several possible side effects to be more pronounced. Right now I'm on 200mg Fluconazole in the morning and 1mg Tactrillimus in the morning and .5mg Tacrolimus in the evening. Secondly, I was told to check and then keep track of the manufacturer of the medications I'm taking. Apparently, some drug stores will give you the same drug although they might switch it out with a different manufacturer. I was told you can ask the drug store to check into that and confirm. I haven't looked into either yet as I just got this information yesterday. But I do plan to look into both.

Jump to this post

I was on Fluconazole / Diflucan when I had a pancreas transplant going on 19 years ago. At that time my Dr. started reducing the dose. Could that be an option or is there an alternative med that could be considered?

REPLY
Mentor
Rosemary, Volunteer Mentor | @rosemarya | 2 days ago

Here is a link to another discussion where members with transplants are also engaged in conversation about their joint pain experiences since their successful organ transplant.

Joint Pain after Organ Transplant
https://connect.mayoclinic.org/discussion/joint-pain-liver-transplant/

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