Is there anyone that had estrogen positive cancer, without use of AI?

My advice is to try all AIs (including Fulvestrant) and Tamoxifen before you give up. I did poorly on Exemestane and Letrozole and OK on Anastrozole. Please be aware that in a sense all cancer drugs are toxic. Below is something I posted on a different thread. But it might be helpful.

Alternative dosing letrozole: https://pmc.ncbi.nlm.nih.gov/articles/PMC4740217/
Alternative dosing tamoxifen: https://pmc.ncbi.nlm.nih.gov/articles/PMC11101371/
Alternative dosing exemestane: https://pubmed.ncbi.nlm.nih.gov/36951827/
Alternative dosing anastrozole: No studies that I could find.

According to my medical oncologist, the studies cited above show that lower doses of AIs or Tam lower estrogen just as well as higher doses. What these studies do **not** show is that lower doses are as effective as usual (higher) dose in reducing risk of recurrence. Of course, that doesn't mean that lower doses don't work--but there's no scientific evidence that they do.

Thanks for the information. I left an email message for my doctor last Thursday, asking him if the side effects will go away with time, but I haven't heard back yet. I did stop the anastrozole though. The pain was intense. I will try them all, plus the tamoxifen, but if they're not tolerable, I'll have to take my chances. I already suffer from chronic pain, which started way before the cancer diagnosis. Lots to think about, but I will give them all a try. Thanks again for taking the time to send your reply.

I have stage one ER positive breast cancer, and had a lumpectomy with radiation. My risk of recurrence is low and while I could further reduce it with AIs I have chosen quality of life at this point. I am very willing to assume the risk after the research. All of us have a different risk tolerance. Good luck in your decision!

I have HR+ Her2- cancer, a recurrence after 32 years of no treatment after chemo +mastectomy. I tried AI's, they drove up my Blood pressure, so am now on next level, Fulvestrant, another type of hormone receptor "antagonist." Works differently than AI's. No problems with BP, just headache for a couple of days after the 2nd series of shots. It even lowered my high BP, since it has vessel dilation effects too. I take lower BP drugs with it.

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I'm doing all the above and decided I've had enough pain in my life, as my father worked me like a grown man, my bones always hurt. My pancreas decided I'd throw up for 2 hours after eating, so painful, I take creon for that. I have osteoarthritis. Watch Barbara O'Neil and follow her advice.
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