Is there a connection between b6 toxicity and thyroid issues?

I have the EXACT problem. B6 toxicity from food alone and have hypothyroidism. Your story sounds exactly like mine. I tried cutting back on b6 foods, done tons of labs, taken tbyroid medication, etc. I’ve posted my journey on a Facebook group.

I believe I have a rare form of hypothyroidism called central hypothyroidism that is driving it.

I also have peripheral neuropathy

Anyway we can connect to compare notes and try and find a solution?

If links are allowed I could send you my documented journey and comments from the Facebook group.

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Hello @lbishop, Welcome to Connect. Here's some information that explains the connection between the thyroid and Vitamin B6 that might be helpful.

"Does vitamin B6 affect thyroid?
Without this vitamin, the thyroid cannot utilise its iodine raw material efficiently to make the hormones. Pyridoxine B6 is needed even more by an overactive thyroid. Muscle weakness is very common in people with an overactive thyroid and in those who are also lacking in B6."
--- Vitamins and minerals and their importance for the Thyroid: https://thyroiduk.org/role-of-vitamins-and-minerals/.

You mentioned that you have been avoiding any supplements and trying to eat a low B6 diet. Do you drink any of the popular sports energy drinks which can be high in B6?

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@johnbishop thank you for the information on B6 in regards to thyroid. I have heard that vitamin B has an impact on neuropathy but had no idea there was any connection to thyroid issues.

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You have to take Pyridoxal 5 phosphate(active b6). This is the active version of b6, it is safe in large doses unlike inactive form pyridoxine. Active and inactive both work against each other in the body. Large amounts of pyridoxine will actually make you more deficient in b6 even though it shows up in your blood stream, you have to check your blood CELL. Half the population cannot convert pyridoxine into the active form Pyridoxal 5 Phosphate that goes into the cell. Unable to convert pyridoxine, it builds up in your system. The more active form you take the more it lowers the inactive form. I had every symptom of b6 deficiency which is also the same as the b6 toxicity and I landed myself in and out of the hospital. No one knew what was wrong with me. After learning this I took fully active forms of b vitamins including extra active b6 and each day I took it I got progressively better, I went from being bed bound and having seizures , swollen thyroid nausea every symptoms to feeling amazing after taking the active form. Before this My blood showed I was high in b6 in my blood stream but it wasn’t making its way into the cell, which is where genes come into play because if you have the MTHFR gene you don’t have the enzyme to convert inactive to active form. Causing deficiency or toxicity. Half the population has this gene. It’s hard to find a fully activated b complex but Klair Labs has one you can find on Amazon. Magnesium is needed to activate b vitamins. Glycinate is a good one. Hope this helps

Jump to this post

You have to take Pyridoxal 5 phosphate(active b6). This is the active version of b6, it is safe in large doses unlike inactive form pyridoxine. Active and inactive both work against each other in the body. Large amounts of pyridoxine will actually make you more deficient in b6 even though it shows up in your blood stream, you have to check your blood CELL. Half the population cannot convert pyridoxine into the active form Pyridoxal 5 Phosphate that goes into the cell. Unable to convert pyridoxine, it builds up in your system. The more active form you take the more it lowers the inactive form. I had every symptom of b6 deficiency which is also the same as the b6 toxicity and I landed myself in and out of the hospital. No one knew what was wrong with me. After learning this I took fully active forms of b vitamins including extra active b6 and each day I took it I got progressively better, I went from being bed bound and having seizures , swollen thyroid nausea every symptoms to feeling amazing after taking the active form. Before this My blood showed I was high in b6 in my blood stream but it wasn’t making its way into the cell, which is where genes come into play because if you have the MTHFR gene you don’t have the enzyme to convert inactive to active form. Causing deficiency or toxicity. Half the population has this gene. It’s hard to find a fully activated b complex but Klair Labs has one you can find on Amazon. Magnesium is needed to activate b vitamins. Glycinate is a good one. Hope this helps

Jump to this post

Hello @lbishop, Welcome to Connect. Here's some information that explains the connection between the thyroid and Vitamin B6 that might be helpful.

"Does vitamin B6 affect thyroid?
Without this vitamin, the thyroid cannot utilise its iodine raw material efficiently to make the hormones. Pyridoxine B6 is needed even more by an overactive thyroid. Muscle weakness is very common in people with an overactive thyroid and in those who are also lacking in B6."
--- Vitamins and minerals and their importance for the Thyroid: https://thyroiduk.org/role-of-vitamins-and-minerals/.

You mentioned that you have been avoiding any supplements and trying to eat a low B6 diet. Do you drink any of the popular sports energy drinks which can be high in B6?

Jump to this post