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Is it true that failed kidneys is where PD starts?
Has anyone seen this?Is it true or bs?That failed kidneys is where PD starts.
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Has anyone seen this?Is it true or bs?That failed kidneys is where PD starts.
Interested in more discussions like this? Go to the Parkinson's Disease Support Group.
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Kidney problems can be part of Parkinson’s, but it starts in the brain. Lots of other things can be part of it,also.
@eojeda1 I thought They had determined that everyone has the genetic markers but not everyone flips enough switches to develop PD.
No. Everyone has genes, but not everyone has genetic variants (mutations) that are known to increase the risk of Parkinson's disease. Approximately 85–90% of Parkinson's cases are not directly inherited. These are called sporadic cases and are thought to result from a combination of aging, environmental exposures, and many small genetic influences.
Approximately 10–15% of cases have a stronger genetic component, often involving variants in genes such as
LRRK2 (the most common known genetic cause in some populations)
GBA1 (increases risk but doesn't guarantee Parkinson's)
SNCA
PRKN (Parkin)
PINK1
DJ-1
Having one of these genetic variants does not mean someone will definitely develop Parkinson's, as there are people with a risk variant who never develop the disease. People without any known Parkinson's gene variant can still develop Parkinson's disease, indicating that aging and environmental factors play an important roles.
As of yet, no one knows the single cause of Parkinson's disease. For the majority of people, there is no known action that would have reliably prevented the disease from developing.