Inflammatory arthritis

Systemic inflammation affects every organ system in our bodies.
Your lab numbers should guide treatment so be aware of all results.
If you are seeing a rheumatologist they should have other options
for relief. Consider Mediterranean diet and have your cardiac risk
assessed for prevention. Some SSRI anti depressants have a positive
effect on lowering inflammation causing cytokines in the brain.

@jonesc, I think inflammatory arthritis is a group of conditions that can stem from various causes including genetics. Here's some information on inflammatory arthritis - https://www.ncbi.nlm.nih.gov/books/NBK507704/. Here's another resource that might be helpful:
-- Management of inflammatory arthritis: https://www.nice.org.uk/about/what-we-do/into-practice/measuring-the-use-of-nice-guidance/impact-of-our-guidance/nice-impact-arthritis/management-of-inflammatory-arthritis

jonesc, Has your doctor tried Mobic with you? It is the least hardest on the gut & reflux as far as an NSAID goes.
You may want to ask about this one.

Blessings & Prayers....

I've been doing well on the Advil Dual Action (acetaminophen and ibuprofen in one pill). I have stomach issues with ibuprofen alone, but this is okay so far. Amazon has a generic that will save you a lot. The pills are exactly alike, even the printing. It is likely a business like Perrigo makes both. Good luck!

Jan in Lansing, MI USA

I am also on hydroxychloroquin, and I feel like I have arthritis in my knees and legs. I too have been very depressed because I have been diagnosed with Scleroderma. I am also taking Sulindac to help with osteoporosis.

Haven’t tried the Tylenol+Ibuprofen yet. Using Aleve gels like candy and doesn’t seem to last. Thought about stacking the different nsaids, so this may indeed provide relief. I’m also taking Hydroxycloroquine 40cg/day. It’s been 12 weeks. I’m waiting? I’ll do another month then try something LDN. I too experience knee and muscle pain. Right now I’m testing with ice packs, which help after too much activity… which really isn’t much compared to life before this.

Oh thanks I’m going to try ice packs.

Mobic (meloxicam) does nothing for me. I've tested that 7.5mg), daypro (600mg), and ibuprofen (400mg x twice a day). The ibuprofen works best and has the least stomach upset as long as I take it with food.

I was diagnosed with inflammatory arthritis (based on my inflammatory markers) about 4 years ago by a wonderful rheumatologist at Mayo Clinic in Rochester (a rheumatologist at a different clinic didn’t do sufficient testing a diagnosed me with fibromyaligia). My doctor at Mayo prescribed a high level of Prednisone (20 mg) initially with a slow reduction. He also prescribed hydroxychloroquine which made me feel really out of it. He switched me to leflunomide and I felt much better. I eventually ended up on a maintenance dose of 5mg prednisone and 20mg leflunomide and felt great for several years. I recently had a full knee replacement which flared up my symptoms, but I’m working on getting it back under control by increasing the prednisone to 10mg and slowly tapering back to 5 mg. It’s important to take the medications with food. I take mine with yogert.

@svillalobos4

I was also diagnosed with scleroderma in 2022. It started as just a little bit of skin involvement over the fingers but then progressed rapidly in the past 2 years to the rest of my skin, joints, and GI. I also got Raynaud's vasculitis along with scleroderma.
The worst symptoms are coming from inflammation in the joints: stiffness, swelling, lack of mobility, fatigue. It is considered a part of scleroderma with only two approved treatments: methotrexate and mycophenolate (Cellcept). I also feel Flu-Like and fatigued all the time.
Did anyone have a good response to NSAIDs for these symptoms?
Any other drugs or joint supplements that helped?