In praise of Orgovyx

Posted by northoftheborder @northoftheborder, Oct 7, 2024

I'm hardly an old vet here (my stage-4 prostate cancer was diagnosed just 3 years ago), but I've seen big changes in treatment even over that short time.

In my opinion, the biggest improvement has been Orgovyx. Getting a Firmagon injection was like having the flu, a stomach rash, and a fist-sized swollen reaction to a wasp bite ... Every. Single. Month.

The past six months on Orgovyx — just another daily pill — have been like night and day for my quality of life. I find it puzzling when I read people posting about how "awful" Orgovyx is, and then I remember that they're not comparing it to Firmagon but to life before ADT.

So maybe I am an old vet after all, since I'm comparing things to the bad old days (uphill in the snow both ways and all that). 😉

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

Profile picture for jeff Marchi @jeffmarc

I take Diltiazem, Losartan and Metoprolol twice a day for high blood pressure (Due to Zytiga). All my blood tests are normal and really don’t change from month to month. Been on them for over 4 years.

I guess the right drugs make a difference. The question is what are the right drugs, it must vary depending on a person’s medical makeup.

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Phil, Jeff, others. Just saw this after getting my bloodwork done in prep for PT.
I’ve been on Orgovyx since Jan 25. No significant SEs compared to what I hear on the forum. But checking my BP it was very high again. I didn’t think about the ADT causing that rise.

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I’m so glad it’s an improvement and working well for you. I must be a special case: I’m in my eighth month of Orgovyx and am experiencing every side effect the manufacturer lists. All the best for ongoing success!

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Profile picture for jime51 @jime51

I’m so glad it’s an improvement and working well for you. I must be a special case: I’m in my eighth month of Orgovyx and am experiencing every side effect the manufacturer lists. All the best for ongoing success!

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You are not a special case. The whole purpose of Orgovyx Is to reduce the testosterone level down to undetectable or close to it. The same thing is true of all other ADT products. As a result, side effects are pretty much the same no matter what ADT drug you are on.

I can tell you that after having seven years of Lupron and two years of Orgovyx that there isn’t any difference In side effects.

They might start slower when you are on Orgovyx, But the testosterone effects are the same as are the side effects.

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Profile picture for jeff Marchi @jeffmarc

You are not a special case. The whole purpose of Orgovyx Is to reduce the testosterone level down to undetectable or close to it. The same thing is true of all other ADT products. As a result, side effects are pretty much the same no matter what ADT drug you are on.

I can tell you that after having seven years of Lupron and two years of Orgovyx that there isn’t any difference In side effects.

They might start slower when you are on Orgovyx, But the testosterone effects are the same as are the side effects.

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I agree that 0 Testosterone should create the same effects in a person, but I notice a wide disparity in patients’ number and severity of side effects.

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Profile picture for jime51 @jime51

I agree that 0 Testosterone should create the same effects in a person, but I notice a wide disparity in patients’ number and severity of side effects.

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I agree, from the posts I’ve read comparing the two drugs. I think it’s all about the sledgehammer effect of an injection vs the slower - but just as effective- decrease of T in that first 30-60 days from an oral tablet.
I too had every SE while on Orgovyx, but they slowly accumulated over time and the last month (of 6) brought them all together.
Accordingly, that last month was the toughest and I was very happy to know that I would be off it soon.

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Profile picture for robertmizek @robertmizek

My side effects from Orgovyx have been quite tolerable. Hot flashes, fatigue, body aches, and brain fog have all been minimal. I have maintained some libido and I get through most days with little problem. I applied for and received a grant to cover my medication cost until I hit the catastrophic level so my out-of-pocket costs have been minimal.
I’m looking forward to faster recovery of testosterone and rebuilding loss muscle at the end of ADT.

Good luck to everyone who reads this on their journey with PCa!

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The side effects of Orgovyx ( sweats, fatigue ) are not pleasant , but , as you say , tolerable. But on the plus side , it's wiping out my PSA , I sleep great and don't have to worry about deleting my Pornhub history! LOL

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Profile picture for jime51 @jime51

I’m so glad it’s an improvement and working well for you. I must be a special case: I’m in my eighth month of Orgovyx and am experiencing every side effect the manufacturer lists. All the best for ongoing success!

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I am sorry you're experiencing many side effects listed by the Orgovyx manufacturer. My 6 months in Orgovyx will end in September; I'm hoping my favorable experience will continue until then. I also hope your situation will improve, see a reduction in SEs,

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Profile picture for jime51 @jime51

I agree that 0 Testosterone should create the same effects in a person, but I notice a wide disparity in patients’ number and severity of side effects.

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As with everything else with prostate cancer side effects from ADT vary from person to person.

Even though I’ve been on it for nine years I’ve had never had a fatigue problem, but I have a terrible, hot flash problem.

I also never had depression from it and never gained weight from it, But many do.

The loss of muscles, The weakening of bones and Some cardiovascular problems affect almost everybody. Brain fog is another issue that only affects some people, And usually requires longer term use of ADT.

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Profile picture for heavyphil @heavyphil

I agree, from the posts I’ve read comparing the two drugs. I think it’s all about the sledgehammer effect of an injection vs the slower - but just as effective- decrease of T in that first 30-60 days from an oral tablet.
I too had every SE while on Orgovyx, but they slowly accumulated over time and the last month (of 6) brought them all together.
Accordingly, that last month was the toughest and I was very happy to know that I would be off it soon.

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Hope you feel great sooner than later!

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Profile picture for jeff Marchi @jeffmarc

As with everything else with prostate cancer side effects from ADT vary from person to person.

Even though I’ve been on it for nine years I’ve had never had a fatigue problem, but I have a terrible, hot flash problem.

I also never had depression from it and never gained weight from it, But many do.

The loss of muscles, The weakening of bones and Some cardiovascular problems affect almost everybody. Brain fog is another issue that only affects some people, And usually requires longer term use of ADT.

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I don’t know that my hot flashes are notable, but one or two will wake me up at night and I averaged one hourly on a trip this week while driving. It just feels like my scalp and face are melting but I’m not completely miserable

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