I have to have EMG/ NCS test done as a result of leg muscles failure

I’m throwing out an idea - may be way out in left field - but if it were me I’d be asking about whether this is a new onset of autoimmune myositis (muscle inflammation). There might be elevated creatine kinase (CK) levels. I’m not a medical professional, but my granddaughter has a type of myositis with main feature of leg weakness. She was having difficulty getting up from the floor. She has a juvenile version, but some myositis are more found in late 40s or 50s.
If you’re interested you could probably find info on the web - here is some info I found:
https://www.sciencedirect.com/science/article/pii/S1297319X21001810#:~:text=We%20presented%20three%20cases%20of,stopping%20AI%20is%202.5%20years

Hi! @timely:

I am so sorry that you've been through so much, my heart and prayers went out for you upon reading this post!

Unfortunately for me, I am not a medical expert and I can't provide any medical help; however, the serious leg muscle failure that you'd experienced worries me. I am afraid that what you've been suffering may indicate some serious health issues other than the side effects that had been caused by taking Letrozole; because you had stopped taking Letrozole for almost 2 months now and have still had this same muscle weakness:( If I were you, I would definitely keep the appointment of ultrasound scheduled first week in October with a vascular surgeon to evaluate vein circulation, and would try to schedule an appointment as soon as possible with my primary care physician to evaluate my overall health providing him/her with all my ongoing treatments and medications that have been taking. I am so sorry for your suffering, my comrade...

Best wishes to you all on the journey ahead with better health, hope, peace and love!

@lifetraveler

I will go to the vascular surgeon Oct. 9th.

I have a new appointment for December for the EMG/CMS and am on a wait list for cancellations for after the vascular surgeon appointment and ultrasound in October.
That makes more sense.

I have an appointment with my Internist for the end of October already. So, he can figure out everything after the ultrasound.
See medical oncologist end of October too.

All my muscle loss is caused by the Letrozole which also gave me plantar fasciitis and foot and leg neuropathy in the last month or so of taking it. Letrozole causes muscle loss, neuropathy, and plantar fasciitis.

I was so wiped out by the Letrozole in the last year of taking it that I could not exercise much.
It also added more arrhythmias to my arrhythmias. That is not as bad now.

Hi! @timely:

I truly think and firmly believe that you should discuss all these painful issues and ongoing treatments with your primary care physician as soon as possible.

I really can't provide any medical advice / opinion because I am not any medical expert; I can only share with you how I deal with all my body's reactions to the lack of estrogens after taking any AI medicines to block hormone production. Due to the fact that I declined the radiation treatment for fear of its potential long term effect at my old age, I decided that I have to continue taking Anastrozole, Letrozole, etc., to keep the BC recurrence at bay and mitigate these pain & aches with physical therapy. Earlier this year, I experienced acute neck pain along with numbness and tingling pain in both arms. Unfortunately my PCP suffered a family emergency at that time, so her assistance sent me back to PT/OT to reduce my pain. Got a referral to see a doctor of PHYSICAL MEDICINE & REHAB; and this new doctor confirmed that I indeed suffered Neck pain and BL arm dysesthesias. He recommended EMG test to measure the electrical activity of muscles and nerves to diagnose nerve and muscle disorders. I asked for MRI CERVICAL SPINE Without CONTRAST instead, because I am certain I have multiple issues of nerves, what is the point to identify which nerves are acting up? Further, I also am scared of the needle insertions to my various nerves during the EMG test procedure. Thankfully, the MRI confirms that I have Anterior osteophytes on the front of my neck bones and disc osteophyte (bone spurs) at other spots, so I continue my PT sessions diligently to get the relief. Later on when I saw my surgical oncologist and asked her to review my MRI cervical spine report, she confirmed that physical therapy is my best and only ongoing option.

Sorry for such a lengthy note, Timely! I pray that you get to discuss all your issues with your PCP soon and get the most accurate diagnosis and best treatment going forward.

Best wishes to all!

Sorry it happens to you. I hope that with time your legs will regain their strength. I don't have any advice because I didn't experience that while taking Letrozole. I just want to wish you good luck and pray that you will regain muscles strength. If the side effects are that bad, maybe you should not take Letrozole again?

I've tried all three AIs and the worst one for me is Letrozole. I had migraines so badly that they woke me up at night. Aromatase inhibitors affect everyone differently! Hugs.