I Can't Decide Between Allogeneic or Autologous Transplant

Posted by chrissyade19 @chrissyade19, Jun 23 6:47pm

Hi, I’m 29 and I'm going through the process of being evaluated for a stem cell transplant but my medical history is somewhat complicated, which is making the transplant process even more complex. I have sickle cell anemia, which has been relatively stable for the majority of my life until I was 27, when I was diagnosed with two autoimmune disorders, RA and scleroderma. Both of the AIDs have made my sickle cell worse and my sickle cell has made the AIDs progress more quickly than they should have, which has negatively impacted my quality of life. My hematologist said I have two choices: I can either do a BMT, which would get rid of all 3 diseases, but it’s riskier, the mortality rate is higher and there are other factors to worry about like graft vs host disease. The other option is I do an autologous (they would use my own cells) stem cell transplant. It’s safer and the mortality rate is not as high, but it would only take care of my AIDs, meaning I would still have to live with sickle cell. I keep going back and forth between the two; on one hand, it would be nice to be free of all these diseases, but I’m terrified of all the risks and complications associated with it. I have so many other things going on in my body because of the scleroderma and it has caused so much damage to my body. Sometimes I have this fear I’ll die from the BMT. On the other hand, the autologous route is safer and I could live with the sickle cell. However, my fear is that if I relapse or the HSCT doesn’t work for my AIDs and I still have sickle cell, I’ll be back where I am right now. I don’t expect anyone to tell me what to do and my case is more complex since I don’t just have sickle cell, but I was hoping to hear from others who have done a bone marrow transplant if they think it’s worth the risk or not? What would you do if you were in my situation? Thanks.

Interested in more discussions like this? Go to the Bone Marrow Transplant (BMT) & CAR-T Cell Therapy Support Group.

Profile picture for ajdmyers @ajdmyers

@chrissyade19
I dealt with anxiety during/after my BMT in January 2026. If you haven’t discussed your anxiety symptoms with your Mayo team, I encourage you to do so. They have dedicated providers to help us through the mental health challenges of SCT and I found them very supportive. I chose to start some meds that made a huge impact on my ruminating and sleeplessness.
Peace be with you!

Jump to this post

Hi @ajdmyers I wanted to officially welcome you to Mayo Connect! Thank you for popping into the conversation and being a morale booster for @chrissyade19. It's members like you who have walked the walk, that can make such a difference in the lives of anyone just entering the stem cell transplant journey.

You're still a newbie with your BMT, having gotten your 2nd chance at life in January 2026. I hope you'll become a regular in our BMT support group. My BMT was 7 years ago at Mayo Rochester so it's always fun to have fellow BMT alum join in. There so many discussions where your recent experiences can be helpful, from long term lodging, to how you recovery has been...

If you'd like to share more of your journey with us, you can start a new post or join many of us here in this discussion I started several years ago.
My bone marrow transplant story. Will you share yours?
https://connect.mayoclinic.org/discussion/my-bone-marrow-transplant-bmt-story-will-you-share-yours/
Another fun discussion is this one where we're encouraging patients with any type of transplant to post a memory or photo that wouldn't be possible without the transplant!
Snapshots of hope: Life on the other side of transplant https://connect.mayoclinic.org/discussion/snapshots-of-hope-life-on-the-other-side-of-transplant/

If you don't mind sharing more about yourself what brought you to needed a BMT?

REPLY
Profile picture for chrissyade19 @chrissyade19

@loribmt Hi Lori, I apologize for not responding but thank you once again for your detailed response. It made me feel less alone. I did end up making a decision and I'm doing the autologous stem cell transplant, which is scheduled for next week Saturday. I've been feeling overly fearful and anxious when I think about the transplant. I think I've been in such a negative headspace for so long because everything that has happened to me that I feel like I've forgotten how to hope again. I'm a Christian and this has really tested my faith. There are days when I feel like throwing in the towel. I get angry and question why God would allow this to happen to me. Everyone that I've talked to that has had a stem cell transplant have all said it was worth it and greatly improved their quality of life, so I don't understand why I'm struggling to believe that it will happen for me too. I don't know if it's pre-jitters but I'm scared. I have a good team of doctors and they've been great and my family has been supportive, so i think I'm the problem. I just want my life back. I'm tired of walking around with a broken heart.

Jump to this post

@chrissyade19
Chrissy, I will pray for your steady recovery from your ASCT. I had an auto transplant 18 months ago & am feeling very well at this point. Recovery does take a few months, but you will regain your energy & a much more positive outlook as you will be feeling better. Blessings 🙌

REPLY
Please sign in or register to post a reply.