Has anyone microdosed with HOCM (in lieu of anti-depressants)?

I would ask the Cardiologist since I think this question requires professional help regarding side effects.

Hello @rmhc123. This is a very complex question. So much so, that even medical professionals warrant that more research needs to be done, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661823/.

In your case, @manuelpo gives simple, but prudent, advice. You'll likely need to talk with your provider. Because there is ongoing research, it may come down to what your cardiologist thinks is safe based on your situation. If you don't mind sharing, are you currently on anti-depressants? Do those have any contraindications with your HOCM?

i macrodosed with mushrooms taking metropol 25 mg. 2x 1.5 g and was fine have done it several times. deep spiritual healing

have HOCM with gradient 50-75

@joanallione, please inform your cardiologist that you also use mushrooms. Mushrooms and their active ingredient psilocybin are being researched for their potential to treat a range of psychiatric and behavioral disorders. But mushrooms are not regulated and are not yet approved by the FDA for any use.

You can also talk to your pharmacist about possible interactions to find out if psilocybin may reduce the effectiveness of your prescribed medications.

Joan, did your cardiologist recommend your current dosage of
metoprolol?

I am w Colleen on this. I like the idea of something more natural but natural substances can be very strong. I have been talking alfalfa for lung heath and figured out it is high in vitamin k which can disturb clotting balance. Who would have thought, something that seemingly begnien? There are do many factors w this HC so advocate for you but always work w your medical team.

Hi @rmhc123

I apologize for the late response that I did not see before till today to respond.
I am not on on anti-depressants and I have some contraindication with my HOCM. I searched contraindications for HOCM and I found "nitrates" (which my Cardiologist already told me to avoid them no matter what), ACE inhibitors also can increase outflow tract obstruction. Also Nifedipine-type calcium antagonists: Can increase outflow tract obstruction. All this information I found online:
Drugs to avoid in obstructive HCM.
Nitrates.
ACE, ARB: . . . . ...
Dihydropyridine CaCB: Nifedipine, Amlodipine; . . . ...
Alpha blockers: Terazosin (Hytrin), Tamsulosin (Flomax), Doxazosin (Cardura), . . . ...
PDE5 inhibitors: Sildenafil (Viagra), Vardenafil (Levitra), . . . . ...
Dobutamine, Dopamine, Digoxin.

However, only an expert Cardiologist specialized in HOCM has the best advise that I would suggest to ask that contraindication question. I hope you feel better.