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Has anyone found a treatment that helps with peripheral neuropathy?

Posted by bigjohnscho @bigjohnscho, Jul 1, 2025

I suspect that everyone on this forum has been searching for a medication that helps their neuropathy and even though you no that all the internet claims are false we continue to waste hundreds of pounds. Desperation is a powerful force. Has any one been fortunate enough to find a genuine treatment. I just can’t believe that there are so many awful people who prey on our vulnerability and knowingly orchestrate such elaborate scams.

Interested in more discussions like this? Go to the Neuropathy Support Group.

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reddakota1 | @reddakota1 | 1 day ago
In reply to @cleveland26 "@reddakota1 Did you slowly decrease dosages of gabapentin or did you stop quickly? Many on this..." + (show)
Profile picture for cleveland26 @cleveland26

@reddakota1 Did you slowly decrease dosages of gabapentin or did you stop quickly? Many on this forum have commented that trying to get off it was a nightmare. I take 300mg four times a day, 1200mg total. I am down from 2400mg a day since taking R alpha lipoic acid 300 mg three times a day, total 900 mg. I also take vitamin B12, methylcobalamin. My diabetic neuropathy is pretty well controlled now but I would like to reduce gabapentin even mote if not entirely eliminate it. It makes me a little foggy brained and affects my balance.

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@cleveland26
I started out with one Duloxetine at night and dropped 900 Mg at that time. About a week later I dropped my 900 Ng of Gabapentin at 4:00 in the afternoon. Then I was prescribed 1 more Duloxetine at night and about a week or two later I dropped the last 900 Mg of Gabapentin.
Never seemed to be any problems at least for me.

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loria2 | @loria2 | 1 day ago
In reply to @sash "Sarapin is rated highly by patients and pain clinics for safety and short‑term nerve‑pain relief, especially..." + (show)
Profile picture for sash @sash

Sarapin is rated highly by patients and pain clinics for safety and short‑term nerve‑pain relief, especially when steroids aren’t an option.
But scientific evidence is weak, so results vary.

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@sash
I did find an NIH article, 2004:
"Conclusion: This prospective, double-blind trial of 500 patients undergoing 828 treatments, one time with Sarapin and a subsequent time without, with each patient acting as their own control, showed no significant differences in the pain relief or duration of significant relief with the addition of Sarapin." https://pubmed.ncbi.nlm.nih.gov/16868612/

And from Azon Medical: "It works by stopping pain signals in the nerves of the spine where they exit the spinal column. It does not affect any other nerve or motor functions, nor is it affected by heat or cold."

I think you are correct - need more studies.

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cleveland26 | @cleveland26 | 1 day ago
In reply to @reddakota1 "@cleveland26 I started out with one Duloxetine at night and dropped 900 Mg at that time...." + (show)
Profile picture for reddakota1 @reddakota1

@cleveland26
I started out with one Duloxetine at night and dropped 900 Mg at that time. About a week later I dropped my 900 Ng of Gabapentin at 4:00 in the afternoon. Then I was prescribed 1 more Duloxetine at night and about a week or two later I dropped the last 900 Mg of Gabapentin.
Never seemed to be any problems at least for me.

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@reddakota1 Thanks. That is helpful as I'm trying to decide whether I will try to discontinue gabapentin and start duloxetine.

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dennisntexas | @dennisntexas | 1 day ago
In reply to @formerrunner13 "There is no cure for neuropathy. I would think that after 16 years you would see..." + (show)
Profile picture for formerrunner13 @formerrunner13

There is no cure for neuropathy. I would think that after 16 years you would see that. I have learned to live with it. I do not take medication. I exercise and eat healthy food. I have learned that I am more than my neuropathy as well as my other health issues.

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@formerrunner13 wow Mr Buzzkill. New treatments are being tried all the time. I realize this has been the typical thinking for some time. I can't agree with you when I've already seen improvement from CET treatments. I dont think a blanket statement like that is totally true. That said, yes their are scams out there. Do your research before you spend money on wishful treatment. One litmus test is the treatment covered by ins. CET was covered by Medicare. Its not as one said, a silver bullet, but it has helped me a lot.

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Profile picture for aml25
aml25 | @aml25 | 1 day ago

A topical formulation of Pirenzepine 4% called WST-057 is currently undergoing clinical trials for diabetic PN. It has completed phase 2b trials. Will be several more years to complete phase 3.
From what I have read this cream could greatly help, even regrow peripheral nerves.
WinSan Tor has a Compassionate Use Program you can sign up for. Doesn't say insurance will cover the cost.

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bingo2a | @bingo2a | 1 day ago
In reply to @nscaccia "Thanks for everybody’s input. I have been experiencing feet numbness for about a year now on..." + (show)
Profile picture for nscaccia @nscaccia

Thanks for everybody’s input. I have been experiencing feet numbness for about a year now on the upper side of my foot just below my baby toe toes. I see a commercial almost every day about neuropathy. It looks like they’ve hooked the patient up to tens unit. I purchased one in a while ago for back pain which helped a lot so I’ve been using it on my feet along with soaks with hydrogen peroxide in the water. I’ve also been taking food grade hydrogen peroxide diluted with distilled water daily. It’s supposed to help with all Cellular issues as well as nerve issues. I’ve been doing the routine now for about six months along with liquid magnesium, vitamin D and turmeric tea. So far so good it hasn’t progressed and I don’t seem to have the numbness like I did when it first started. Thank God, I haven’t experienced any pain per se this occasional achiness of which I’ll use a massage device on my feet to help with that. I hope this helps and I’ll continue reading what others are doing.

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@nscaccia Did your doctor tell you to use hydrogen peroxide for soaking and drinking? Thank you.

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hotrodbob01 | @hotrodbob01 | 22 hours ago

Tried Gabapentin without any positive effects. Stopped it and feel better, lost weight. My doctor prescribed Capsaicin cream and I use a over the counter cream, Momma Bear (Magnesium). Both have helped. I first reported this 16 years ago to my doctors, but no support from them was given until I strongly questioned my care. Not giving in or up. I will push as hard as I can for better treatment.

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bubba2112 | @bubba2112 | 15 hours ago

Yes, stay off of the Facebook neuropathy pages. Ive found a few normal people and we talk about our experiences. But honestly I believe the admins are the culprits selling their “snake oils”. I went almost all the way to purchase with a couple just to see. Both promised to “cure” my neuropathy in 2 weeks with herbal drinks that looked like soda bottles. But as soon as I started questioning them they were like “don’t you believe”. “Send money and we will begin creating your cure.”Then after I don’t respond they say you are not believer goodbye.
So frustrating. I see numerous people on there falling for it even though many members try to warn them. Just stay off those pages.
Rant over
Kevin

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Profile picture for mrmacabre
mrmacabre | @mrmacabre | 2 hours ago
In reply to @aml25 "A topical formulation of Pirenzepine 4% called WST-057 is currently undergoing clinical trials for diabetic PN...." + (show)
Profile picture for aml25 @aml25

A topical formulation of Pirenzepine 4% called WST-057 is currently undergoing clinical trials for diabetic PN. It has completed phase 2b trials. Will be several more years to complete phase 3.
From what I have read this cream could greatly help, even regrow peripheral nerves.
WinSan Tor has a Compassionate Use Program you can sign up for. Doesn't say insurance will cover the cost.

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@aml25 Nerves can not be regrown, period.

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