Has anyone else had rare reactions to statins?

I can’t take statins either and had horrible knee pain with Ezetimibe. My MGH cardiologist just ordered Nexletol which I was told by even my pharmacist is the last line of defense to lower your LDL. I haven’t tried it yet. I just got it but I’m hopeful and I hope it helps. It’s a brand new cholesterol, lowering medication.

@backhand Any cognitive side effects? I recently took injection number two, three months after the first. I have had some extreme episodes of memory loss. For a brief period, I lose very basic items from my memory, like the location of my kitchen, how to turn off the alarm, like my middle name. Then memory returns and I feel unsure of it for a while. Then normalcy returns. My daughter calls them moments of being scatter-brained and says I have never been scatter-brained before. Any episodes of being scatter-brained? Unusual memory loss?

@tatiana987 No, no cognitive effects but I have only had the first dose. I get the second dose in a month. I will let you know how it goes. With Repatha, the side effects kept building up and just got worse as time went on, really limiting my athletic activities and causing some depression. After 3 to 4 months off Repatha all the side effects went away.

Thanks. I appreciate your input.

Don’t you consider depression a cognitive effect?

Your description of Repatha is a lot like how it affected me. I got light-headed and fell repeatedly, so it was dangerous. And over time that got worse. When I detoxed from Repatha,, I was fine.

Since the strange, new “scatter-brain” experience on Leqvio, I am starting to think that my brain needs the higher LDL number to work right. Does that sound crazy? Or maybe it’s just that I am not adjusted yet.

@judithlynne be careful with Nexletol may increase your risk of tendon rupture or injury.

Oh no! I haven’t started it yet. Did this happen to you? Any specific area to be aware of? This is my last line of the defense to lower my cholesterol as I can’t take Ezetimibe or statins. Do you have a recommendation for something else? Thank you so much.

@tatiana987 Yes, you are right, depression is a cognitive effect. So no cognitive effects, including no depression on Leqvio. How low did your LDL go on Leqvio? I will be curious to see what happens to mine, I get a test in 3 weeks. My LDL on Repatha dropped to 54. Your theory sounds interesting, I will be curious to see how I am after the next shot. Glad that that effect went away for you, or is it still there a bit? Diet makes little difference for me, I eat a mostly vegan diet and get lots of exercise. It is all a bit much really, but we need to keep trudging on, LOL

@backhand To answer yr question about my LDL, I have had the first test (after the first Leqvio shot) and I had gone from 160 to 100. My diet seems to have no effect on the number. I eat the true Mediterranean diet, not the silly inaccuracies in the America medical establishment’s version that they call the Mediterranean diet.

Please explain to me why this Mediterranean diet from America wants us to eliminate pasta (mainstay in Italy) and ham (mainstay in Spain) and white bread (mainstay in France). And yet they claim (using life span and medical data from Italy, Spain and France) that Americans would become healthier and live longer, like people in Mediterranean countries if they ate the fictional version of the Mediterranean diet created by American medical folks. Hiw do they profit from such inaccuracies?

Reminds me of new book by Didier Raoult about fictions around the Covid disasters. Came out this week. “La Société du Factice”. It’s about fictions in contemporary medicine,