Has anyone been prescribed bupropion + mirtazapine to treat depression

I was prescribed Mirtazapine last summer, I must say that I have a lot of difficulty adjusting to antidepressants except Amitriptyline which is an older medication. I was taken off this and prescribed Mirtazapine, the first week on it I began to have disturbing dreams, I then began having leg cramps along with restless legs. I began complaining to the pharmacist about my symptoms and he advised me to speak to my doctor. I was on this medication for about two months and I weaned myself off it, I would normally do so with the doctor’s approval but he kept telling me to give it time. I was given this medication because it’s in the same class of antidepressants that I was taking, I never had any problems with the other med I took but I truly had a bad time. Please realize that this was my experience and everyone is different so it’s not to say that you’re going to have side effects. If you want to learn about a new medication go online and you’ll get more information than you need, I have a habit of doing this and it can scare you away from taking it. If you ask other people who have taken it can also be confusing because you’re going to get a lot of mixed opinions.

@frouke
Thank you. I never took Mitrazapine before. I have taken some antidepressants and had few side effects that were tolerable and other medications that caused me terrible side effects (Prozac, Abilify, etc.) that I weaned myself off. The side effects were not worth it to me and I didn’t get any benefit. They tried augmenting Wellbutrin with Abilify and it didn’t work so now they want to try Mitrazapine. I have been struggling with major depression for over 15 months and frustrated that medications tried and dosage adjustments have taken so long and I haven’t improved much and struggling to function. I really want my old self back!

The newer SSRI’s are a vast improvement over the older antidepressants. I am surprised your Doctor would even be prescribing them.
I would suggest you ask him about Zoloft along with Wellbutrin. They actually call it WellOft since they compliment themselves so well. I have taken that plus Buspar for many years
Good luck to you.

Even with SSRI’s some cannot tolerate one medication but another medication in the family can be well tolerated and effective.
I found that with Statins. The first one my Doctor prescribed gave me some side effects and she switched me to Atorvastatin and I have had no side effects.
I would suggest rather than looking online that you rely on your Doctor for advice. If you read the side effects of any medication you probably will decide not to take it.
Good luck to you.

Well said.

I was taking both for severe depression stemming from chronic migraines. No side effects from the Wellbutrin but the Remeron just made my headaches worse. The Abilify-Wellbutrin helped my depression significantly, however this combination caused me to have the shakes bad enough that people thought I had Parkinson’s. The anti-psychotic meds with the SSRI combination seems to help. Been on Seroquel with the Wellbutrin but that seemed to cause Tardive Dyskinesia. The SSRI/anti-psychotic combination seems to help my depression significantly. I think the antipsychotics help a lot but they seem to have worse side effects.

@daveshaw, I’m happy for you that you and your doctor were able to find something else for you to take and it didn’t cause you any problems. Were it possible that everyone could find the right medication so quickly, we would be so much happier in our lives. I have lost count as to how many different medications I tried to take and failed each time due to profound side effects that were worse than the ailment. Every time you try another drug you get messed up by the side effects and then you have to stop them and wait for your system to calm down, then you’re given something else and that doesn’t work so onward you go until you can’t deal with it anymore. Consider yourself very lucky and I hope that things don’t change for you down the road.

@daveshaw
Thanks. I will ask about Zoloft and Wellbutrin if the Mirtazapine and Wellbutrin do not work. Wellbutrin doesn’t seem to be a problem as long as I do not go above 300 mg (450 mg caused agitation). I had been on Zoloft in the past but do not believe I was ever prescribed Zoloft and Wellbutrin at the same time.

I am certainly not a Doctor but I did try Remeron and I had terrible side effects.
I had the best luck with a combination of Zoloft,Wellbutrin and Buspar. Zoloft is I think one of the most described antidepressants and pairs very well with Wellbutrin.
Good luck. Finding the right combination is tough and you are right that it is like starting over again.

Prescribed