Getting off of Seroquel

Posted by anniegk @anniegk, Jun 8, 2018

I have been on 300 mgs. Seroquel ER for over a year for augmenting my antidepressant which is 45 mgs. Of Mirtazapine. I decided to try and get off of the Seroquel. I was on 300mgs ER (extended release). I titrated down to 250 mg ER for 2 months without too many problems.than i titrated down to 200mgs ER just 5 days ago. My plan is to try to titrate off using ER tablets. My thinking is that perhaps the drug will remove its self from my system more gradually. I have had some nausea and a couple of episodes of diarrhea. I also have a very irregular heart beat and was started on 60 mgs of Propranolol ER (extended release) 4 weeks ago. It seems to be helping my heartbeat. I have wondered if the nausea and light headness is from the Propranolol, a Beta Blocker, or the dose reduction of the Seroquel. I also wonder if the way iam titrating the Seroquel is safe. My doctor says it will only take a couple of weeks…I think that is too fast of a taper after being on a drug for over a year. What do you think?

I am finding this book helpful:
The Brain That Changes Itself by Norman Doidge
(Brain Fitness Program featured on PBS)

Also: SELF TALK by Aston Sanderson
We often get stuck, replay the negative: Practice self love!

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@lisalucier i think they do know when I am having one, which is great. I was diagnosed with type 2 bipolar. Was on lithium for 10 years and they took me off due to my kidneys. I have hyper manic moment and depression. But the depression is the worst part. Most people love my hyper manic moods. The panic attacks mostly happen at night, but mostly they are controllable. I have ended up in ER a couple of times but that was when I first started getting them but now I know it’s not a heart attack. But hay things could be worse for me. I have to look on the bright side

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@wickedbillie

@lisalucier i think they do know when I am having one, which is great. I was diagnosed with type 2 bipolar. Was on lithium for 10 years and they took me off due to my kidneys. I have hyper manic moment and depression. But the depression is the worst part. Most people love my hyper manic moods. The panic attacks mostly happen at night, but mostly they are controllable. I have ended up in ER a couple of times but that was when I first started getting them but now I know it’s not a heart attack. But hay things could be worse for me. I have to look on the bright side

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@wickedbillie – thanks for the background on your diagnosis with bipolar 2 and your lithium treatment. Have your kidneys improved since you quit taking it?

Do you take a medication that helps prevent panic attacks?

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@highserotonin30

This is a low dose. I've been on it for a few months. Is it safe to quit taking it cold turkey? It's for insomnia and depression. I take it alongside 30 mg Lexapro and 100 mg trazodone.

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Did you ever successfully get off the meds? I’m struggling and I’ve been on 50mg for 2 weeks and I didn’t take it last night is it ok you think?

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@tness360

Hello everyone I am new around here!
I am a 20 y/o male and when I was 7 years old I was put on Quetiapine. I believe it was for anxiety or something but I do not remember much of my childhood. Anyways fast forward to now and I have been taking Quetiapine for 13 years and I don't even know why I am taking it. I am currently taking Quetiapine 50mg ER once a day at 5:30-7pm each day. My doctor tried to ween me off last year around this time by cutting my down to 25mg daily for 2 weeks followed by 25mg every other day for 4 days, after that I went cold turkey. The withdrawal was okay at first but eventually I think I had a panic attack or something and was put back on it. Anyways, my question is how can I got off this drug I've been on for 13 years? Im worried about the effects on my liver and other cognitive effects such as it being incredibly difficult to wake up

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Hi the good news is you are only 20 years old. So take your time and never go cold turkey. You'll need to change to the regular seroquel. (Don't know what the dosage equivalent is – maybe your psychiatrist does.) Then you can begin with a small decrease in dose (very small) – reach stabilization, park awhile – then small cut in dose again – reach stabilization, park awhile – (you get the picture) until you're off. Listen to your body, if it's uncomfortable, you're going too fast. Nobody knows your body like you do (no doctor, no one.) Eat whole foods, exercise, and enjoy being 20. Best of Luck : )

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Hello, new here. I've been coming off seroquel for a couple of weeks now. Was able to taper 50mg at a time (starting from 300mg) with no side effects but after I got off completely, that's when the problems started. James, thanks for all of your feedback.

I've noticed something among other members that's also affecting me: I'll sleep one night and feel ok for most of the next day, then not be able to sleep the next night and lie awake with riddling anxiety. I used to have itchiness, but that went away about four days ago. Also cried a lot but that seems to have subsided. A few nights ago, I would close my eyes and have a terrible panic attack then be jolted awake and feel terrified.

I tried to use ativan to help the withdrawals for a few nights but it only worked once. I tried klonopin, 0.5mg during the last night I slept. I dont know if it helped. Also worth mentioning is that I tapered from 1.3mg of klonopin since last july and have been clean for just over a month, I did it at 0.05mg per 2 weeks, as the ashton manual says. I dont want to go back on the klonopin for fear of becoming dependent again.

Around the same time I cut the seroquel, I was also tapering paxil. I've been on the paxil, same dose, for over a week now and believe it to be stabilized.

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@jakehun

Hi All looking for advice,

On the 6th of Jan2020 i was prescribed 25mg seroquel for very mild insomnia. I took this dose for the next month and it worked a charm.

Now come 6th of Feb2020 i stopped seroquel due to lapse of my prescription, the next few days my sleep started to worsen from 6hours for two days then no sleep at all on the 9th.

I went back to my doctor about this the next day, he gave me no instructions or warnings and just prescribed the same dose of seroquel and 15mg of mirtazapine as i requested.

My sleep timeline then follows:

10th: tried to sleep with no medication whatsoever i caved at 2am and took 7.5mg of mirtazapine and was able to sleep.

11th: I slept surprisingly well for 8 hours with no medication.

12th: Slept for a maximum of 1 hour

I really do no want to be on sleep drugs anymore. But should i try and start retaking seroquel then taper off to ease the withdrawals or is it too late for that?

Im quite frighten that i have permanently ruined myself by taking seroquel after doing research on it.

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This is the same thing I'm going through. I'll sleep good one night then none at all the next. This has been happening for almost a week now. How are you coming along?

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@chrisjc

Hello, new here. I've been coming off seroquel for a couple of weeks now. Was able to taper 50mg at a time (starting from 300mg) with no side effects but after I got off completely, that's when the problems started. James, thanks for all of your feedback.

I've noticed something among other members that's also affecting me: I'll sleep one night and feel ok for most of the next day, then not be able to sleep the next night and lie awake with riddling anxiety. I used to have itchiness, but that went away about four days ago. Also cried a lot but that seems to have subsided. A few nights ago, I would close my eyes and have a terrible panic attack then be jolted awake and feel terrified.

I tried to use ativan to help the withdrawals for a few nights but it only worked once. I tried klonopin, 0.5mg during the last night I slept. I dont know if it helped. Also worth mentioning is that I tapered from 1.3mg of klonopin since last july and have been clean for just over a month, I did it at 0.05mg per 2 weeks, as the ashton manual says. I dont want to go back on the klonopin for fear of becoming dependent again.

Around the same time I cut the seroquel, I was also tapering paxil. I've been on the paxil, same dose, for over a week now and believe it to be stabilized.

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Hi, Chris and welcome. I alternated nights like you because I think after a sleepless night the body needs sleep so badly that it finally does. What worked for me was just persisting through it. I used melatonin and a bunch of other stuff to try to ease off it but eventually I just had to suffer a few nights and get it out of my system. I had the same experience as you. Everything up to the final 25 mg was fine but the last 25 mg caused the insomnia.My doctor suggested that I go back on 25 mg Seroquel to ease the insomnia and also suggested Ambien which I said no to. The insomnia eventually passes as you learn to sleep again. Basically, you "just" have to train the body to sleep. You've been so used to having it happen automatically that you've forgotten how to do it. So good habits, same bedtime, no phone blah blah. Calm mind, remind yourself that it will pass and you will sleep soon. Postpone everything you can to later and get this out of the way first. Good luck!

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@jh1

Hi, Chris and welcome. I alternated nights like you because I think after a sleepless night the body needs sleep so badly that it finally does. What worked for me was just persisting through it. I used melatonin and a bunch of other stuff to try to ease off it but eventually I just had to suffer a few nights and get it out of my system. I had the same experience as you. Everything up to the final 25 mg was fine but the last 25 mg caused the insomnia.My doctor suggested that I go back on 25 mg Seroquel to ease the insomnia and also suggested Ambien which I said no to. The insomnia eventually passes as you learn to sleep again. Basically, you "just" have to train the body to sleep. You've been so used to having it happen automatically that you've forgotten how to do it. So good habits, same bedtime, no phone blah blah. Calm mind, remind yourself that it will pass and you will sleep soon. Postpone everything you can to later and get this out of the way first. Good luck!

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James!! I have read every one of your messages, many times. Your feedback has been very appreciated. You had the same experience too? That's amazing. I didn't feel any withdrawals until days after my last dose of 50mg (I was using seroquel xr). I dont want to use benzos either. The anxiety and panic has been so scary for the last two weeks.

I went through my browser history to piece together a small diary from the past few days (I will keeping it updated from now on):

"On 3/10: Went to sleep at around 9pm, woke up at 7am. Felt fine until about 5pm, then it all went downhill. Anxiety and stomach issues. Benzo use that night, dont remember that night but likely ativan 1mg. I remember crying a lot that day.

On 3/12: Went to sleep at round 7pm, woke up at 6am. Benzo use was 0.5 clonazepam Felt fine until about 7-9pm, then anxiety and stomach issues persisted"

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Hi all,

I thought members in this thread talking about getting off of quetiapine (Seroquel) might be interested to know that Mayo Clinic Connect has opened up a brand new group dedicated to COVID-19, https://connect.mayoclinic.org/group/covid-19/. The hope is to help members connect and cope during these unprecedented times.

Please follow the COVID-19 group by clicking on +Follow, look at the discussions there and participate. You are also welcome to start a new discussion on any COVID-19-related topic you'd like to discuss.

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@jh1

Hi, Chris and welcome. I alternated nights like you because I think after a sleepless night the body needs sleep so badly that it finally does. What worked for me was just persisting through it. I used melatonin and a bunch of other stuff to try to ease off it but eventually I just had to suffer a few nights and get it out of my system. I had the same experience as you. Everything up to the final 25 mg was fine but the last 25 mg caused the insomnia.My doctor suggested that I go back on 25 mg Seroquel to ease the insomnia and also suggested Ambien which I said no to. The insomnia eventually passes as you learn to sleep again. Basically, you "just" have to train the body to sleep. You've been so used to having it happen automatically that you've forgotten how to do it. So good habits, same bedtime, no phone blah blah. Calm mind, remind yourself that it will pass and you will sleep soon. Postpone everything you can to later and get this out of the way first. Good luck!

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I went back on a low dose of seroquel, roughly 50mg. It worked well. But I kept having to increase it until last night when it stopped working. Today I think I took about 150mg but it's not working. I fear I'll have to go through withdrawals again, I'm asking my parents for support. I can not go through it again alone. The first time was horrible.

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@chrisjc

I went back on a low dose of seroquel, roughly 50mg. It worked well. But I kept having to increase it until last night when it stopped working. Today I think I took about 150mg but it's not working. I fear I'll have to go through withdrawals again, I'm asking my parents for support. I can not go through it again alone. The first time was horrible.

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What does your do doctor say about this?

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