Anyone else out there with extremely high lipoprotein (a)?

What brand of whey protein did you use?

Lysine, an amino acid, has shown potential in reducing Lp(a) levels when combined with vitamin C. A study in postmenopausal women found a significant decrease in Lp(a) levels after 6 months of taking 3 grams of ascorbic acid and L-lysine monohydrochloride daily, with a 48% reduction in one individual. This regimen is based on the theory that lysine can inhibit Lp(a) binding, while ascorbic acid aids in collagen repair and acts as an antioxidant.
Elaboration:

Lysine's Role:
Lysine is an essential amino acid that plays a role in protein synthesis. In the context of Lp(a), it's believed that it can interfere with the binding of Lp(a) to other molecules, potentially reducing its ability to contribute to plaque formation.

Vitamin C's Role:
Ascorbic acid (vitamin C) is a potent antioxidant that can help repair collagen damage in blood vessels, potentially reducing the overall impact of Lp(a) on the cardiovascular system.
Combined Approach:
The combination of lysine and vitamin C has shown promising results in reducing Lp(a) levels, particularly in individuals with elevated levels and a family history of heart disease.

Shortly after discovering I had blockages that were ultimately corrected via 3 stents (July of 2022), it was determined that I had elevated LP(a) levels (221). As others have noted, statins and lifestyle changes won't lower LP(a) levels. I found one study that suggested whey protein (approx 60 gms (2 scoops)) was effective in lowering LDL.
In Sept of 2023, I started taking whey protein.
In July of 2024, I applied for a clinical study of Lepodisiran (phase one trial had shown a 90% reduction).
Much to my surprise, my LP(a) had dropped to 117 (still too high, but a nice improvement).
I stopped the whey protein in thehopes of being retested and accepted into the trial.
One month later, my LP(a) was back up to 160, not quite high enough to be accpeted into the study.
I resumed my daily whey protein intake, and in Dec 2024, it was down to 88.

I'm in the same boat. Mine is 438. I thought I was doing ok until I had my last Echo and ECG. Not only showed narrowed arteries and calcification, but I had a surprise silent heart attack. I've done a lot of research since I found out I have high Lpa. My primary had no clue what to do a bout it, or if it even needed to be treated. I haven't been able to find much about what to do about it. The consensus it is bad and it raises our chances of heart attacks and complications a lot. Unfortunately I have no clue of how to get treated or with what. I am looking into joining some studies. I know I didn't help much, but at least you know you're not alone.

Rapatha brought my LPa down a little. same here my family lives to be in their 90's my mother is 87 LPa 455. No stroke No heath problems. I think the stress is the worst part.

I added Rapatha and my LPa went down to 435 and LDL 65 HDL85. I am going to switch to crestor from Lipitor. Rapatha brings LPa down a little not much.

Yes, I have 300+ level. Cardiologist put me on 20mg rosuvastatin and baby aspirin. I don't believe statins do much when their side-effects are taken into effect. And nothing can be done about Lp(a)? I thought I was in pretty good health for a 65-yr-old. Active. Work full-time. Now I wonder if I'm going to die soon. Folks in my family generally live to be old!

I have a LPa of 556 second test first was 600. now on lipitor 20 mg and add Rapatha. waiting to get test in a week to see if my LPa goes down. New drug coming out.

My LPa was 600 and went on 20mg of lipitor and changed my diet. Went down 565. Added Rapatha and will test again in a week. This news was very stressful. Only my mother who is 87 would test. She came back with LPa 455. I had a calcium score of 31 with mild mixed plaque. Very clean diet, no smoking, no alcohol, and very rerely eat meat. Hike walk 7 miles a day. So was very surprised. Always had high cholesterol but they always said good high HDL out weigh bad LDL. Feeling like this new stress will kill me.

Try reaching out to Novartis…here is the link. I could not find a study being conducted in Norway. Their outreach number is towards the bottom of the link. My trial office told me they are willing to pay for travel to be in the trial.

They are anxious to get some results….give them a call. It is worth a good try.
https://www.novartis.com/clinicaltrials/study/nct05646381