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Evenity Injection Site Pain and The Next Step

Posted by berniebrooks3 @berniebrooks3, Jul 11, 2025

Hello Everyone - I just had my 9th set of Evenity injections in my arms two days ago. So far this is by far the most painful I’ve felt following a arm injection. They haven’t really bothered me before except for a little tenderness. Last month I had the injection in the back of thigh and 1 month later I’m still in quite a bit of pain. I can’t sit for more than a few minutes without great discomfort (including driving a car). Prior to last month, I’ve never had discomfort with the thigh injections. I spoke to my doctor and she waved me off saying that this can happen….Although I really hate the stomach injections, I’ll do that for my 10th injection next month. Wondering if anyone else has experience with injection site pain as the series progressed. I’m also hoping the pain in the back of my thigh will dissipate soon. It’s not getting any better after a month so far….Like others, I also have joint pain that continues to worsen and am really hopeful that is will improve after my last injection. I’m not sure what I will do after Evenity. My doctor likes Reclast but I had terrible side effects when I first tried Fosamax (also a bisphosphonate….) I am not a big fan of prolia because it doesn’t kill or suppress Osteoclasts and I don’t want to be on a drug for life. Of course I sure don’t want to rebound after all that I’ve been though. I’m researching Keith McCormick and may try to get an appt with him for his advice. I have been an athlete all of my life and now I don’t want to get out of bed. This all happened so quickly….I love this blog and any and all advice is so greatly appreciated. My best to all you girls on this journey.

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angie37167 | @angie37167 | May 2 8:03am
In reply to @lauratys "I have commented earlier. I did 11 months of Evenity with injections in my arms. Injections..." + (show)
Profile picture for lauratys @lauratys

I have commented earlier. I did 11 months of Evenity with injections in my arms. Injections were a bit painful but tolerable and arms felt fine after a couple of day. However, my bigger concern was the muscle and bone pain that I never had before the injections. I thought I had ruined my health as it was painful to bend down, walk, aching all over all the tine, I also was not believable to my provider when I shared concerns but she attributed it to anxiety, etc. I do think she had rethought this as so many more are communicating about this issue. She is very thorough so I do trust her. I am healthy and active and run, walk, ski, mountain bike, etc. I could barely put on a pair of yoga pants after 6-7 months of injections. The good news is I stuck it out for 11 months and had amazing gains in my spine, -3.8 to -2.1. Hip and other site minor increases but they weren't as bad so took me out of osteoporosis zone. That was two years ago and it took me probably 6-7 months after no injections to be rid of the pain. Now, I am due for DEXA this month and have been on Actonel. Was on Fosomax following Evenity and that increased pain in muscles and bone so switch to Actonel and I have been fine. Will hopefully have decent numbers with DEXA this month. I do recommend Great Bones by Keith McCormick.

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@lauratys
My arms are hurting for 30 days now like I have exercised too much. My whole body hurts. I am on my 5th shots. I am thinking of not getting anymore because I can barely use my arms. The never hurt badly until my 5 th shot

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lauratys | @lauratys | May 2 8:57am
In reply to @angie37167 "@lauratys My arms are hurting for 30 days now like I have exercised too much. My..." + (show)
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@lauratys
My arms are hurting for 30 days now like I have exercised too much. My whole body hurts. I am on my 5th shots. I am thinking of not getting anymore because I can barely use my arms. The never hurt badly until my 5 th shot

Jump to this post

@angie37167 Hi! I totally understand what you are saying! I am so sorry as this can be difficult to make a decision whether to continue or not. My DEXA scores are stable since on Actonel for 2+ years and I am now on a drug holiday! Praise God! I would look into whether the most bone building is in first 6 months as I did learn of that after the fact for me and I probably would have quit sooner due to the discomfort but am thankful for the gains made. Now just watching diet, supplements and doing strength training to keep strong. Don’t want to make this my life’s mission so just doing the best I can as I don’t want to fall apart either. Best to you and listen to your body as we all are different!

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