Evenity

👍I’m gonna hang in there. Glad you are doing well with it. Makes me hopeful. I need to get better with exercising. Joined the Y. Bad osteoporosis in spine. I really don’t have any back problems. Just don’t know about equipment and don’t want to make it worse. Any suggestions

Good to know. Unfortunately, I was never given any helpful instructions. Glad that you were. I would still never take an Evenity injection again.

Thursday Jan 23, 2025

update Evenity

After more than a year of treading on water of indecision:
I have decided not to take Evenity: Two main reasons.
One is some of the reports I have seen on the web: which I am linking
here.
And, as an older person, there are, I think,
cardiac risks that might not be foreseen,
For example as we age, we all get Arteriosclerosis, can get strokes and so on.

Please realize this is my decision, my choice and I am not
impinging, influencing anyone’s decision.
If you have taken, or are taking this drug, you have
done your due diligence and found that this path was the
right one for you.

I will link to the studies that have helped make up my mind.

I would like to take a few minutes of your time:
to thank the participants who have presented their skepticism
so clearly and articulate
of Big Pharma and the doctors and specialists we see: many of
whom are
not focused on the well being of their patients, but overly
dependent on quick fixes, namely pills.
That is the culture we
live in today. Unfortunately. And it will take brave souls
who highlight these to make a change. Amen.
Some of you know about Martin Shkreli - raising insulin meds from $13.50
to $700.
He was sent to jail, had to pay some fine, he's out of jail now,
was left with a personal fortune of approx 70 Million.
His lawyer is trying to reverse a
condition whereby Shkreli cannot return to the pharma world.
He is working as a software engineer somewhere.

@windyshores
Also, I would like to use this space to say thank to @windyshores
for her kindness and empathy that she shows especially to
new participants, and to others.
In spite of her many health challenges, she exemplifies graciousness
and patience in her communication - which sometimes
is not matched in kind by posts she has lately received.

Here’s link to one study from the Australian Government 2023
https://www.tga.gov.au/news/safety-updates/new-warnings-romosozumab-evenity-cardiovascular-risks
2019 Evenity is not approved: July 1, 2019
https://pharmaphorum.com/news/chmp-says-no-to-amgens-osteoporosis-drug-evenity
“In its assessment, the advisory committee said “as it was unclear why the medicine
appeared to increase the risk of heart and circulatory problems, and there was no
obvious group of patients in whom the risk of these was lower, measures to reduce
the risk could not readily be put in place.”

and
“The CHMP was also not convinced about the efficacy of the drug in
patients with less severe osteoporosis, saying the “benefit was not so convincing”
in this group.”

A Quick Turn About - a few months later Oct 19, 2019
https://pharmatimes.com/news/chmp_u-turn_for_evenity_1313762/
this next one is FDA
https://pharmaphorum.com/news/at-long-last-amgen-ucb-score-fda-okay-for-evenity
Amgen and UCB finally have FDA approval for osteoporosis drug Evenity, two years after
it was turned down by the regulator because of safety concerns.

BTW Amgen will start losing Evenity patent in the U.S.
in 2025… earlier in Europe

Eliminating Evenity, puts me closer to deciding on another anabolic
drug.

I have ‘severe osteoporosis’ - numbers that most health professional
have told me they have never seen.
It’s taken me a over a year to not panic, and try to arrive at what I
think I should be doing.
I’m almost there.

Thank you for those graphs. However, I am not clear on them showing Evenity becoming anti-resorptive in the latter months.

Hi @normahorn when you click on the attached image, does it allow you to scroll to the bottom to see graph D on the left (for P1NP %changes from baseline) and graph E on the right (for CTX % change from baseline)? If not I will try to attach the image some other way. Thanks

Yes, I saw that. But does that mean anti-resorptive behavior? I think that is a stretch.

It looks like so but it's up to the experts to give this phenomenon a name. We see during early months (2wks after 1st dosing being most responsive) on avg there was 150% increase in p1np while ctx decreased an avg 50% - signals its dual-action with a net overall effect of bone formation. The second half of the treatment year especially towards the few months in the end, p1np trended towards baseline while ctx remained below baseline - bone markers behaved simikar to an antiresorptive but not exact. This paper analysed evenity's effect based on bone histomorphometry analysis at 2 and 12mo, the authors called it 'bone-forming and antiresorptive effect':
https://pmc.ncbi.nlm.nih.gov/articles/PMC7027577/
Interestingly there is a similarity in the behavior of p1np and CTx when comparing monthly evenity dosing with teriparatide once weekly dosing, seen in the publications by Japanese researchers. Teriparatide wasn't called an antiresorptive in anyway so...

Leder explains a similar chart in the YouTube, which may be helpful for folks to understand. Again, I was told they don't really understand how Evenity actually works since the expected anabolic action didn't last as long as expected and the anti-resorption is fairly mild. I can only repeat what I have been told and what I see in a video by a researcher who is respected in the field.

I have one more Evenity injection. I am usually a canary in the mine, but the only symptoms I had was pain at the injection site. It only lasted a few days. I have broken a hip, so pain for a few days, no sweat! I took the injections in my stomach and the slower she went, the less pain I had afterwards. I hope it worked!

I have also been wondering about this. I think I have bradycardia but it seems doctors still want me to start the shots. I am scared to death!