Evenity

Posted by bayhorse @bayhorse, Jan 14 12:46pm

Does anyone know whether Evenity is still contraindicated for people with cardiac issues? I know initially it was deemed a risk, but I either heard or read about a year ago that that had changed. If anyone has or knows where to find recent info, I'd appreciate hearing about it.

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@windyshores

@bayhorse my lay person's reading of this https://pmc.ncbi.nlm.nih.gov/articles/PMC5915244/
is that yes meds to prevent rebound (bisphosphonates) should be started 6 months after the last Prolia shot. I would rely on your endo!

I think "immediately after stopping Prolia" would still mean 6 months after the last shot, since Prolia's action lasts that long. Again, sounds like you have a good endo.

I wasn't "brave" to try Evenity. I was satisfied that the study showing cardiovascular risk on Evenity being the same as placebo to be quite reassuring in that regard. That said, I had other concerns since sclerostin has functions throughout the body. But people are having truly amazing results.

Ineresting experience on Tymlos with a pacemaker!

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@windyshores Thanks again for weighing in. I watched Dr. Leder's YouTube lecture, was surprised to find I followed most of it, but am going to have to watch again to make sure I got things right. He is really impressive!

I am going for a lipid study this week -- I have high cholesterol and have been on Pravastatin, and need to see how well (or not) it's working. (I noticed one article stating high cholesterol seems to be a risk factor where Evenity is concerned.) I think I will feel more comfortable about it if my numbers are good.

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@windyshores

@patwerthman I hope you don't continue to find the reports of heart attacks to be scary. We don't know the circumstances. A comparison with placebo did not show an increase in heart attacks or stroke, though a study comparing it with alendronate showed a difference, small but reported. That might be because alendronate is slightly protective but that has not been proven.

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Thank you. I appreciate that. It’s all somewhat overwhelming right now and I’m just trying to understand and get as much info I can. Figuring it out and how it pertains to my situation

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@grammy9

Did you have heart issues to begin with? I don't have a cardiologist.

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I have cardiomyopathy and an implanted pacemaker/defibrillator.

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