Evenity

I was instructed to take two extra strength Tylenol and an antihistamine an hour before the shots. Depending on who i nexts the shots, and if they are room temperature and slow, I do not have much soreness afterwards. The antihistamine and Tylenol stops some of the inflammatory action.

I will be taking my 8th treatment. Very little side effects except some stomach bloating and a little weight gain. Other than that, nothing else. With Fosamax I started having Gerd and developed some ulcers only after 2 doses. For me, Evenity a much better choice.

Evenity is not like Reclast in that there is not usually, as I understand it, an "acute phase" (immediate) reaction but instead, side effects tend to happen at the peak of action, around one week. The tylenol and antihistamine would seem to address reactions similar to the acute phase reaction that happens with Reclast. Is anyone having that with Evenity?

I did have an immediate reaction that was more akin to allergy, since I am sensitive to polyethylene glycol, which is in Evenity (and some vaccines). This, I was told, was more than unusual. Right after the shot I got strong burning sensations in my tummy and chest, which did not recur when I had shots in my thighs. I differentiate that from some effects I experienced 7-10 days after the Evenity shots.

So are people having an acute phase reaction to Evenity that explains the tylenol and antihistamine?

I too have never heard of Evenity causing bone cancer. I have had 11 sets of shots. One in each arm each time. I experienced redness, pain and itching starting the fifth shots. Scared me. I called the infusion center. They suggested I take a Claritin a half hour prior to my shots. Since then, I have never had a reaction, only mild pain at the injection site that is gone in 24 hours. I did put on weight early on. I really think my appetite increased because I was eating more food. It could be that your body craves more food to build bone. I will have a bone density test the end of February. I am hoping for a gain.

I have seen multiple references to Evenity being anabolic only of the first few months and then becoming anti-resorptive in the last few months but I do not recall seeing a reference to a study showing this. Before acting on the claim, I would like to see study.

@normahorn Dr. Ben Leder, an endocrinologist and researcher at Mass. General in Boston, discusses levels of P1NP and CTX on Evenity, in his video "Combined and Sequential Approaches to Osteoporosis" on You Tube- (minute 40). The video has a chart showing the effect on both bone markers. Leder cites "McLung et all, NEJM, 2014 for his chart.

Keith McCormick discusses it in "Great Bones" but you may be skeptical of that. I will check the studies he references and post later.

My own doctor has told me they don't really "know how Evenity works." On Leder's chart, The P1NP goes up dramatically and rapidly and comes down
fast . It isn't a really strong anti-resorptive, according to Leder. My doctor told me they had expected it to be anabolic the whole year , due to the inhibition of sclerostin, and were surprised that it was not. Leder says P1NP is back to baseline at 3 months. His chart shows CTX rising during the anabolic period and then slowly but steadily decreasing starting at around 5 months.

There is a study ongoing, replacing the last 6 months of Evenity with Reclast and then another year of Reclast. I posted it once, will try to find it since it discusses the fact that Evenity is mainly anti-resorptive in the last 6 months. I also posted an article positing that treatment eventually may involve bursts of Evenity for a few months between times on Reclast or other meds.

The graph👇is from evenity phase 3 clinical trial. It is dual-action based on bone turnover markers with a net anabolic effect obvious in early stages, although bmd kept increasing in later half of the year-long treatment. However the interpretation is up to everyone. The advantages or disadvantages of the hypothesized “modeling based” bone building by evenity, i.e., building new bones at quiescent bone surface, is yet to be studied scientifically.

Try to reload the graph:

What kind of reactions did you have? Thanks.

So far so good for me on Evenity- I’ve had 3 shots so far. I got sick on tymlos too.