Elevated Systolic no matter what

For the BP meds that work, and I have tried just about all, mostly they only work on my diastolic. I am taking an ARB and also some calcium channel blocker and pilocarpine (for other reasons but it helps with BP). My BP this AM is 170/79 and typical with lots of BP meds. If I didn't take the BP meds it might be something like 180/100. So mostly they only work on my diastolic. I see nephrologist but I am sure I am one of the more complicated patients and doc is at a loss generally speaking for what to do with me, but he is way better at BP help than other doctors I have seen. Has anyone had mostly systolic elevation that not much works? What was the cause?