eGFR and creatinine changes unexplained

Posted by kempner @kempner, Jun 6 9:05am

CKD diagnosed in appx 2005, 49 YO, male, 290 lbs, 6'1" with TY 2 diabetes, well controlled. My eGFR at that time was 65 (creatinine at corresponding level). In 2012 dropped to 250 lbs, CKD stable. TY 2 under control. In 12/2023 left high stress aircraft industry job. A1C went from 7 to 6.6. From 12/2023 to 3/2026 eGFR declined to 40. During that time lost another 25lbs. Weight at appx 205 lbs., A1C drops to 5.9. Several adjustments to meds. In 3/2026, eGFR drops to 24. Nephrologist tales me of some meds (b/p, TY 2 and water meds) to see if kidneys recover to 40. After app 6 weeks eGFR rebounds to 62, creatinine at 1.26! Neph at loss to explain. If I had to guess I would say that possibly I have been overmedicated and maybe over hydrating for a long time. Been told for years that damage to kidney tissue is permanent. So if it is permanent, regardless of why it dropped to eGFR of 24, how can it possibly go back to the 60's? Anyone have similar experience or thoughts?

Interested in more discussions like this? Go to the Chronic Kidney Disease (CKD) Support Group.

I can totally relate. I'm 77 and was 170lbs.
9/8 creatine 1.4 gfr 39
Started portion control diet
Feb started mediterranean diet
4/6 creatine 2.7 gfr 17
No explanation
5/29 had lost 34 lbs
Creatine 1.9 gfr 28
Again no explanation, see nephrologist in July

REPLY

Good morning, thanks for your input. Best wishes for your July appointment.

REPLY
Profile picture for knitpurl1 @knitpurl1

I can totally relate. I'm 77 and was 170lbs.
9/8 creatine 1.4 gfr 39
Started portion control diet
Feb started mediterranean diet
4/6 creatine 2.7 gfr 17
No explanation
5/29 had lost 34 lbs
Creatine 1.9 gfr 28
Again no explanation, see nephrologist in July

Jump to this post

REPLY

you might consider a renal dietitian.

I used the online app, Nourish, to connect with a renal dietitian that has been extremely helpful and knowledgeable.

The dietitian didn’t cure me, but she did give me tools to manage the process and the various numbers that you referred to.

The Nourish dietitian is covered by insurance and his virtual.

The app itself is free and I use it on iPhone, but it can also operate an android

REPLY
Profile picture for stuartbell @stuartbell

you might consider a renal dietitian.

I used the online app, Nourish, to connect with a renal dietitian that has been extremely helpful and knowledgeable.

The dietitian didn’t cure me, but she did give me tools to manage the process and the various numbers that you referred to.

The Nourish dietitian is covered by insurance and his virtual.

The app itself is free and I use it on iPhone, but it can also operate an android

Jump to this post

Thanks great advice

REPLY

@kempner welcome to Mayo Clinic Connect. Diabetes and hypertension (high blood pressure) are the two most common conditions that can lead to kidney issues. It sounds like you are working hard at controlling your diabetes (weight loss, diet, monitoring A1C …). Do you monitor your blood pressure too?
I’ve been diabetic for 51 years. I have had chronic kidney disease for the past 21 years. I have an endocrinologist and a nephrologist that practice within the same healthcare system. This makes it easier for the three of us to be “on the same page” regarding my records and treatment plans.
Like you, I have experienced changes in my eGFR over time. The eGFR is affected by lots of things: diet, hydration, changes in weight, exercise, medications, other coexisting conditions, time of day you have labs done, the lab that conducts the tests…. It is best to be as consistent as possible when you get your labs done. That way you can give your provider good information so that s/he can look for trends in your condition. Before I learned this my eGFR would bounce between 14 - 42. It stabilized to the low 30’s.
Three things have also helped. One was to get my diabetes as well controlled as possible. My endocrinologist has developed a good treatment plan for me using a continual glucose monitor (CGM) and an insulin pump. The second was to get my blood pressure under good control. My nephrologist prescribes blood pressure meds and monitors that. The third thing was to learn about nutrition to plan my diet that is both diabetes friendly and kidney friendly. My providers referred me to a dietician that has training/experience in diabetes and renal disease. Being aware of how best to eat for these two conditions has helped immensely. My conditions are both stable. My A1C is 6.3 and my eGFR is 40 at present.
Who do you have for help with your diabetes?

REPLY
Profile picture for Cheryl, Volunteer Mentor @cehunt57

@kempner welcome to Mayo Clinic Connect. Diabetes and hypertension (high blood pressure) are the two most common conditions that can lead to kidney issues. It sounds like you are working hard at controlling your diabetes (weight loss, diet, monitoring A1C …). Do you monitor your blood pressure too?
I’ve been diabetic for 51 years. I have had chronic kidney disease for the past 21 years. I have an endocrinologist and a nephrologist that practice within the same healthcare system. This makes it easier for the three of us to be “on the same page” regarding my records and treatment plans.
Like you, I have experienced changes in my eGFR over time. The eGFR is affected by lots of things: diet, hydration, changes in weight, exercise, medications, other coexisting conditions, time of day you have labs done, the lab that conducts the tests…. It is best to be as consistent as possible when you get your labs done. That way you can give your provider good information so that s/he can look for trends in your condition. Before I learned this my eGFR would bounce between 14 - 42. It stabilized to the low 30’s.
Three things have also helped. One was to get my diabetes as well controlled as possible. My endocrinologist has developed a good treatment plan for me using a continual glucose monitor (CGM) and an insulin pump. The second was to get my blood pressure under good control. My nephrologist prescribes blood pressure meds and monitors that. The third thing was to learn about nutrition to plan my diet that is both diabetes friendly and kidney friendly. My providers referred me to a dietician that has training/experience in diabetes and renal disease. Being aware of how best to eat for these two conditions has helped immensely. My conditions are both stable. My A1C is 6.3 and my eGFR is 40 at present.
Who do you have for help with your diabetes?

Jump to this post

@ca Nephrologist and Endocrinologist

REPLY
Profile picture for elenakroll93welk843 @elenakroll93welk843

@ca Nephrologist and Endocrinologist

Jump to this post

@elenakroll93welk843 I have and endo and a dietician.

REPLY

Nephrologist, Endocrinologist and my primary care is great as well.

REPLY
Profile picture for knitpurl1 @knitpurl1

I can totally relate. I'm 77 and was 170lbs.
9/8 creatine 1.4 gfr 39
Started portion control diet
Feb started mediterranean diet
4/6 creatine 2.7 gfr 17
No explanation
5/29 had lost 34 lbs
Creatine 1.9 gfr 28
Again no explanation, see nephrologist in July

Jump to this post

Now I'm having trouble controlling my body temp.
Hot/cold sweats. Flushing after eating. Go to bed cold, then sweating

REPLY
Please sign in or register to post a reply.