Doxepin (Sileonor) or Vilbryd?

Posted by csmiller @csmiller, Sep 11, 2022

Which of these two drugs is best for major depression and sleep? I need something that is sedating because I'm experiencing major depression. All answers will be appreciated!

Interested in more discussions like this? Go to the Depression & Anxiety Support Group.

maryruth7 | @maryruth7 | Apr 27, 2025

In reply to @dorothy1914 "To @maryruth7 Thank you for your comment. Did your doctor prescribe something else?" + (show)

Hello Dorothy 1914, My Doctor prescribe
Quetiapine 25 mg. Works better.

dorothy1914 | @dorothy1914 | Apr 27, 2025

In reply to @dorothy1914 "From @Dorothy1914 Today my psychiatrist suggested I start taking Doxepin for my severe anxiety, depression and..." + (show)

Thanks.

ClimbingMountains81 | @climbingmountains81 | Jan 24 9:34pm

In reply to @dorothy1914 "From @Dorothy1914 Today my psychiatrist suggested I start taking Doxepin for my severe anxiety, depression and..." + (show)

What did you end up taking? Hope you found some relief!

berekann | @berekann | Jan 25 10:46am

In reply to @dorothy1914 "From @Dorothy1914 Today my psychiatrist suggested I start taking Doxepin for my severe anxiety, depression and..." + (show)

When I looked into doxepin, I opted not to take it because you have to take it three hours after a meal, Which means I’d have to eat dinner at 5 o’clock so I could take it at 8pm to hope that I was asleep by 9pm.
Trazodone is an antidepressant in large doses, but 25 to 100 mg is prescribed for sleep; Even up to 150mg for sleep. It works for some of my friends, but it did not work for me. Made me dizzy and caused dry mouth, Plus, it took me two hours to fall asleep.
I’m not a professional, but I’ve done a lot of research online

addisonshae95 | @addisonshae95 | May 16 12:47pm

In reply to @dorothy1914 "From @Dorothy1914 Today my psychiatrist suggested I start taking Doxepin for my severe anxiety, depression and..." + (show)

I want to try it too. I see my doctor next week. I’m 51, and already on Prozac 20mg but not sleeping at all. I’m getting upset and frustrated at this point. I tried Trazadone which my mom takes and it works for her, but did not work for me the three different times I tried it. I woke up in the morning seeing trails if I moved my hand to turn on the shower. Like I was tripping. I tried Amitriptyline at 25mg and that worked for me for six years , but then I had to raise my dose and couldn’t go past 75mg 12 hours before I had to wake up the next day because my heart was racing like TCAs are known for. I tried Remeron for a while at 12-45mg a night. It made me sleep great but I was always hungry. Then there was Sereqeol I tried at low dose 25-75mg for sleep and boy that helped me sleep for sure. It’s an antipsychotic used off label at low doses for insomnia. I remember though not being able to wake up for work and being groggy all day. So fingers crossed 🤞 Doxepin my doc will even prescribe it. He seems against TCAs saying they’re dangerous. But I’m willing to taper off Prozac while going in the Doxepin to just get some sanity from sleep!!