Does anyone have experience with Mirtazapine?

Posted by faithshouse @faithshouse, Jun 20, 2019

My husband has trouble staying asleep, and falling back to sleep when he awakens during the night. It concerns him, but we wouldn’t say that he is depressed. He had heard about Mirtazapine for sleeping. His doctor prescribed 15 mg. Has anyone had side effects, or depression while taking Mirapine? Is it more for depression, than for sleeping? Thanks for your feedback.

@gettingbetter75

So far so good here, Chris. Yep, I take 5mg Melatonin, 110mg x 2 Magnesium Glycinate, 1x200mg Gabapentin and 1/2 a Unisom Extra Strength tab. At this point, honestly, as long as I can sleep with minimal hangover the next day is all I care about. If I can sleep 5hrs, I'm good. My insomnia journey prior to this is not something I can afford to repeat. I'm not talking, oh a had a bad nights sleep for say a few nights. This was full-blown chronic insomnia that went on for a little over a month. I was losing my grip on reality.

I will be going to a sleep clinic next week to further discuss my insomnia and/or any amelioration I can make in this regard. As an extra FYI for you, all this started when I finished a long time relationship/prescription with anti-anxiety medication. My new doctor (we moved) would NOT continue to prescribe that for me. The anti-anxiety medication might not have been entirely helpful with anxiety per se but it was certainly effective for insomnia. Now that I am off anti-anxiety meds, I have no plans to return on that awful stuff. I do feel a little better, more alive when I can get some sleep, that is. My only significant health issue is my sleep. I need to figure this out long term and I can continue as I was and/or better.

I'm a 44yr old father of two with a full-time eng job, experiencing insomnia at this level is not something I can tolerate again. So going back to the above medication + supplements, I'm OK with that for now. I also use the headspace app to help lull me to sleep. It too is helpful.

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Hi, @gettingbetter – is this regimen of medications you described helping you get 5 hours of sleep nightly at this point? When is your sleep clinic appointment?

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I’m taking Mirtazapine to help with sleep issues as well. I’m currently taking 7.5 mg. before bed and not having any severe side effects.

My husband falls asleep quickly, but will awake around 3am and have trouble going back to sleep. My dr. suggested he try Nuvana Shut Eye, which is a natural sleep aid. It contains all natural ingredients and he’s sleeping better and not waking up drowsy. We purchased on-line and then received a free bottle after giving an online review of the product. I think overall he’s sleeping better and not hindered during the day.

Best of luck, lack of sleep can be an aggravating and can definitely affect quality of life.

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@sandifl

I’m taking Mirtazapine to help with sleep issues as well. I’m currently taking 7.5 mg. before bed and not having any severe side effects.

My husband falls asleep quickly, but will awake around 3am and have trouble going back to sleep. My dr. suggested he try Nuvana Shut Eye, which is a natural sleep aid. It contains all natural ingredients and he’s sleeping better and not waking up drowsy. We purchased on-line and then received a free bottle after giving an online review of the product. I think overall he’s sleeping better and not hindered during the day.

Best of luck, lack of sleep can be an aggravating and can definitely affect quality of life.

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Welcome to Mayo Clinic Connect, @sandifl. I agree with you that lack of sleep can be aggravating. I'm currently not having challenges with sleep, but have for periods before. It's miserable, and anxiety about sleep seems to make it worse.

Sounds like you and your husband have each had some sleep issues and have found different treatments to be helpful.

Do you generally have trouble getting to sleep?

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I have taken 5mg. of Ambien for sleep for at least 15 years. I also take 7.5 mirtazapine for insomnia. I am going to try to taper off Ambien by cutting pills. Any suggestions. I just retired and don't feel my insomnia will effect my new life style ( extra sleep in the early morning feels great).

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Wondering if anyone has had similar problems with sleep and trying to reduce zopiclone sleeping pills.
The last few weeks have been stressful as I became extremely anxious due to worrying about my health. I I was prescribed Amyitryptiline (Now 60mg) but over 4 weeks the sedating effect wasn’t enough to put me to sleep so continued taking zopiclone (Actavis) every night. I’ve used this sleeping pill on and off for years but at smaller doses.
Now I’m gradually coming off the ineffective Amitriptyline and over 3 nights have taken 15mg of mirtazapine. I take it 20 minutes before I go to bed . But by midnight I’m still awake so resort to a whole zopiclone. 7.5mg . Half an hour later I’m still awake so take another half zopiclone … and finally I fall asleep!. Ideally I want to get off the zopiclone and stay on mirtazapine. Next week I’m to start taking 30mg of mirtazapine . Is that more effective and likely to get me to sleep? The anxiety is now worrying about sleep! Love to hear from anyone who has similar experiences or advice on what I should do. Thanks.

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@carolcs

Wondering if anyone has had similar problems with sleep and trying to reduce zopiclone sleeping pills.
The last few weeks have been stressful as I became extremely anxious due to worrying about my health. I I was prescribed Amyitryptiline (Now 60mg) but over 4 weeks the sedating effect wasn’t enough to put me to sleep so continued taking zopiclone (Actavis) every night. I’ve used this sleeping pill on and off for years but at smaller doses.
Now I’m gradually coming off the ineffective Amitriptyline and over 3 nights have taken 15mg of mirtazapine. I take it 20 minutes before I go to bed . But by midnight I’m still awake so resort to a whole zopiclone. 7.5mg . Half an hour later I’m still awake so take another half zopiclone … and finally I fall asleep!. Ideally I want to get off the zopiclone and stay on mirtazapine. Next week I’m to start taking 30mg of mirtazapine . Is that more effective and likely to get me to sleep? The anxiety is now worrying about sleep! Love to hear from anyone who has similar experiences or advice on what I should do. Thanks.

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Hi, @carolcs – welcome to Mayo Clinic Connect. That sounds like quite a sequence to get some sleep at night.

You will note I've moved your post here to this discussion of mirtazapine so you can talk with others who have addressed some of the same issues. Hoping they can provide some input on the anxiety with worrying about sleep and trying to reduce zopiclone and increase the mirtazapine. Please meet @sandifl @gettingbetter75 @contentandwell @faithshouse @artscaping and others here.

When will you be done with your taper off the amitriptyline, carolcs?

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@lisalucier

Hi, @carolcs – welcome to Mayo Clinic Connect. That sounds like quite a sequence to get some sleep at night.

You will note I've moved your post here to this discussion of mirtazapine so you can talk with others who have addressed some of the same issues. Hoping they can provide some input on the anxiety with worrying about sleep and trying to reduce zopiclone and increase the mirtazapine. Please meet @sandifl @gettingbetter75 @contentandwell @faithshouse @artscaping and others here.

When will you be done with your taper off the amitriptyline, carolcs?

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Thanks Lisa. I’ll be off the Amitriptyline by Wednesday this week. 2 tonight (Monday here in NZ) , 1 Tuesday. I will increase the mirtazapine from 15mg after a week to 30mg. Hopefully it will have a sedating affect by then!

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@carolcs

Thanks Lisa. I’ll be off the Amitriptyline by Wednesday this week. 2 tonight (Monday here in NZ) , 1 Tuesday. I will increase the mirtazapine from 15mg after a week to 30mg. Hopefully it will have a sedating affect by then!

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@carolcs. Good morning. @lisalucier has suggested that I jump in here. I am currently getting off Nortryptilene. The first 30 days went reasonably well. The next 30 days may be more difficult…down to 10 mg per day for the next 30 days. It is a little scary. We seem to treat some of these medications like crutches…..to help us get through our day. And I am like a detective watching every possible incidence of depression or anxiety. However, Nortryptilene is an older medication and I have already ramped up the duloxetine with my clinician's support.

I should tell you that I use Medical Cannabis for sleep aid and pain management. One dropper of CBD/THC and I am able to rest without waking during the night because of electric shocks or the burns inside my skin. Good luck and be free of suffering. Chris

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@artscaping

@carolcs. Good morning. @lisalucier has suggested that I jump in here. I am currently getting off Nortryptilene. The first 30 days went reasonably well. The next 30 days may be more difficult…down to 10 mg per day for the next 30 days. It is a little scary. We seem to treat some of these medications like crutches…..to help us get through our day. And I am like a detective watching every possible incidence of depression or anxiety. However, Nortryptilene is an older medication and I have already ramped up the duloxetine with my clinician's support.

I should tell you that I use Medical Cannabis for sleep aid and pain management. One dropper of CBD/THC and I am able to rest without waking during the night because of electric shocks or the burns inside my skin. Good luck and be free of suffering. Chris

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Thanks Chris. Fortunately I haven’t been on the Amitriptyline for long (3 weeks) but it just wasn’t helping me sleep – hence the change to mirtazapine. I’ve only had 5 nights using this but still seem to have trouble getting to sleep without the zopiclone! I’m also taking magnesium at night (2 nights so far) and last night got to sleep but was half awake all night! Weirdest feeling as I was in and out of sleep and by 3am when I became more awake it was too late to take the zopiclone. So today I feel like I have major jet lag! If only we had a switch on our heads we could turn off!

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@carolcs

Thanks Lisa. I’ll be off the Amitriptyline by Wednesday this week. 2 tonight (Monday here in NZ) , 1 Tuesday. I will increase the mirtazapine from 15mg after a week to 30mg. Hopefully it will have a sedating affect by then!

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Hi again, Have just increased my 15mg mirtazapine to 30mg last night as my GP prescribed this increase after a week of being on mirtazapine. (for Anxiety and related insomnia) . Had had two good sleeps prior with 1/4 lorazepam , 15mg mirtazapine and 7.5 zopiclone.
So….the new regime started last night. Got to sleep after an hour of taking it but woke an hour later, dozed and woke another hour later. Because I didn’t want to go thru the terrible in and out of sleep all night that I experienced 3 nights ago I got up and had 1 zopiclone (imovane). An hour later still awake! Up again Feeling dizzy and another half zopiclone. Waited to no avail! Up again feeling dizzy and took another half so two in total. Finally slept! But now what do I do tonight! Take the 30mg mirtazapine again and just try sleeping thru if I wake? Appreciate any advice…thank you…

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Dear Faithshouse: I was given Mirtazapine a long time ago by a Psychiatrist. That was when I was having trouble with another antidepressant wearing off. She said I could try it, but it did nothing to help me. I believe you can gain weight on this and that it is an older antidepressant.

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My doc prescribed Remeron as an alternative to the Zoloft I’d been taking for years. I do not have sleep problems. I had some of the deepest sleep with vivid, positive dreams the first week taking 7.5mg. Really solid sleep with some grogginess in a.m. As the Remeron increased the Zoloft was decreased until I was at 30mg Remeron and 25mg Zoloft. The side effect of this switch — I had a depression unlike any I’d felt in over 30 years. Despair and anguish. The total weaning time from one to the other was six weeks. It was all a huge mistake. Another doc and psychiatrist agreed 1) no need to come off Zoloft and 2) the titration period was not long enough. I’m now reversing back to Zoloft. Felt my depression lift within a couple of days.

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