Polycythemia vera (PV): Does altitude matter?

Posted by toriaflo @toriaflo, Aug 13 1:22pm

I am PV JAK2 and live at an altitude of 6000 feet. Could this altitude harm my condition? What altitude should I avoid?

Interested in more discussions like this? Go to the Blood Cancers & Disorders group.

It does appear that PV can be affected by altitude. Though one study I found has the tests occurring at above 14,000 feet. The pubmed article from the National Institute of Healh studies included patients enduring altitudes over 3100 m which is over 10,000 feet. So, while you’re over a mile high it appears any significant impacts happen well above that.
https://pubmed.ncbi.nlm.nih.gov/707889/
~~
https://ashpublications.org/blood/article/14/4/433/7616/The-Polycythemia-of-High-Altitudes-Iron-Metabolism
I did find one more interesting article regarding secondary PV which can develop from another underlying condition and avoidance of higher elevations can help diminish any side effects. Hopefully this gives you some insights into your situation.

Secondary pylycytemia vera
https://www.verywellhealth.com/secondary-polycythemia-copd-complications-914682#:~:text=Secondary%20polycythemia%2C%20similar%20to%20primary%20polycythemia%20vera%2C%20is,do%20with%20what%20the%20disorder%20is%20associated%20with.
Are you currently on medication or treatment to mitigate your overabundance of red blood cells. Since you live in elevation of 6,000 feet and I’m assuming, being treated in the same geographical area, have you discussed this with your doctor?

REPLY

Welcome @toriaflo. I hope you saw @loribmt's post with some info related to your question about altitude and Polycythemia vera (PV). You may also wish to connect with fellow PV members like @jwn8700 @lindaw123 @tlsantin @hope19 in these related discussions:

– Polycythemia Vera: Just been diagnosed https://connect.mayoclinic.org/discussion/polycythemia-vera-1/
– Polycythemia Vera: Is there anything I can do for fatigue at home? https://connect.mayoclinic.org/discussion/fatigue-2/
– JAK2 Mutation – Effects and Questions https://connect.mayoclinic.org/discussion/jak2-mutation-effects-and-questions/

REPLY

I’m 71 & now 28 mths PV diagnosed… I’ve been in constant (4wks now) DISCOMFORT (pain) with Spleen & waiting for my Haematologist to respond to the ultrasound, (attached below).
From recent Bloods taken (attached below) my HTC count was up & subsequently had Venesection (VS)… Hoping that the VS may have resolved discomfort!?!? Nope nothing has changed, I’m able to sleep right through, most nights, & as soon as I awake it starts again…
Any comments/discussion points WRT above concerns would be appreciated…tks.

REPLY

Sorry… "HCT" count…

REPLY
@bluontene

I’m 71 & now 28 mths PV diagnosed… I’ve been in constant (4wks now) DISCOMFORT (pain) with Spleen & waiting for my Haematologist to respond to the ultrasound, (attached below).
From recent Bloods taken (attached below) my HTC count was up & subsequently had Venesection (VS)… Hoping that the VS may have resolved discomfort!?!? Nope nothing has changed, I’m able to sleep right through, most nights, & as soon as I awake it starts again…
Any comments/discussion points WRT above concerns would be appreciated…tks.

Jump to this post

Hi @bluontene, welcome. Please note that the attached reports were removed from your post because they contained your patient medical record number (MRN). Because this is a public forum, it is best to remove all personal identifying information and institution, physician information.

Have you heard from your hematologist in the meantime to help interpret the ultrasound and explain the hematocrit (HCT) levels?

REPLY
Please sign in or register to post a reply.
  Request Appointment