Diltiazem

I've never heard of this medication. When I was first diagnosed with HCM, and it wasn't obstructive yet (it is now), cardiologist put me on metoprolol. They started me at 50mg daily and went up to 100mg daily. When I first started the 100mg daily, I was exhausted at all times. I needed that dosage so they told me to try taking it 25mg in the morning and 75mg at night. This helped with the fatigue. I would never make any adjustments without cardiologist approval. And if I had your symptoms, I would get in to see a cardiologist asap, or potentially go the emergency room. Good luck!

Hi @mmicahk . Boy does THAT sound familiar! A decade or so ago - well before I was diagnosed with oHCM, I was put on Metoprolol. Don't remember the dosage. Within a very short time I was literally falling asleep at my desk, dozing off while driving... No matter how much sleep I got, I would last about 6 hours and then be completely unable to stay awake. Even had to go on reduced hours at work. I was moved from Metoprolol to Diltiazem within a couple months and that problem went away immediately. Fast forward about 8'ish years and I was finally diagnosed with obstructive HCM (after about 16 years of fruitless investigations), and put on the brand-new Camzyos. Still on Diltiazem along with the Camzyos with zero negative effects. As I've posted here previously (ad nauseum, sorry folks), especially in the discussion below, I had symptoms exactly like what you describe, and within less than 2 weeks ALL of the symptoms were 100% gone. Now I'm back to being the poster-child for lazy with no excuse for lack of activity. Pre-Camzyos I could barely walk to the end of the block but this summer, at age 61, we're looking at a 3 week train & backpack-hiking trip around parts of Europe. Some folks here have not fared as well with Camzyos but it's been life changing (excuse the hyperbole) for me. It may be worthwhile for you to visit camzyos.com to learn about this relatively new medication. Good luck chasing this all down. Take the time to scroll through the many discussions here at Mayo Clinic Connect about HCM, Camzyos, and related topics. This place is a wealth of information and the people here are wonderful about sharing their experiences.
https://connect.mayoclinic.org/discussion/camzyos-mavacamten-prescription/?commentsorder=newest&signin=true&pg=1#chv4-comment-stream-header

Good day from Canada. I am on Candesartan and Diltiazen (a channel blocker) for high blood pressure. When I was prescribed Camzyos in 2024 they stayed the same. My recent ultrasound results have been great and when I asked if I still needed Diltiazen the cardiologist said no ‘you can discontinue it’. I did 10 days ago and my blood pressure has skyrocketed. I’m going back on Diltiazen since I think it made the difference. I’m never sure about the connection between BP and HCM. Be well