Dental work while taking Tymlos?

Posted by shocknot26 @shocknot26, May 22 10:07am

Is there risk with the anabolic medications like there is with the biophosphonates (of ONJ or other issues) when getting dental work? I need to start Tymlos, and am being told conflicting answers. Does anyone have personal experience with this? I have actually seen some studies that being on Tymlos during a procedure can actually help the jaw bone (which might make sense bc isn’t it supposed to help grow bone?). Such confusing information out there. Yes, I am asking all my doctors and dentists too;) Thanks!

Interested in more discussions like this? Go to the Osteoporosis & Bone Health Support Group.

UPDATE: I have now gotten personal face to face opinions from two general family dentists, an endodontist, my GP, my endocrinologist, and my gynocologist. Every one of them said the same thing: anabolic medications lile Tymlos and Forteo will NOT affect dental work. However, the biophosphonates (like Prolia and Fosamax) do increase risk of jaw issues.

I hope everyone who is on this thread can see this update; I am still new to this platform and learning. Thank you for all the support and comments. Take care!

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Profile picture for shocknot26 @shocknot26

UPDATE: I have now gotten personal face to face opinions from two general family dentists, an endodontist, my GP, my endocrinologist, and my gynocologist. Every one of them said the same thing: anabolic medications lile Tymlos and Forteo will NOT affect dental work. However, the biophosphonates (like Prolia and Fosamax) do increase risk of jaw issues.

I hope everyone who is on this thread can see this update; I am still new to this platform and learning. Thank you for all the support and comments. Take care!

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@shocknot26
Thank you for I have exostosis of the mandible. Oral surgeon says good oral hygiene is critical to prevent MRONJ. However according to the Dental Rx guidelines of 2026 it is a risk. My endocrinologist wants to consider Forteo or maybe Tymlos. Not even sure if insurance will Pay although pre authorization may be in my favor. Scared beyond belief. Dexi 2years ago was -2.9. Want to wait for another. The side effects of Forteo and Tymlos are over the top. I take thyroid medicine, blood pressure meds and statin. Afraid. Hair loss? Fatigue? Brain Fog?Weight gain? How long do these last? What will I do after I’m done with either? Please help

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Profile picture for gently @gently

Added risk from Tori would only exist if you decided to have them
removed.The risk of MRONJ from bisphosphonates is not high and happens more
in individuals taking bisphosphonates to protect against cancer metastasis
to the bone. And in individuals who have taken the risk medications for a
long time.
I'm on extended Forteo because I like the way it works and because I don't
like the way other medications work. We lose bone because the cells that
breakdown bone have proliferated more than the cells that build bone. The
two mechanisms work together to keep our bones strong for the specific
activities we engage in and to replace bone that has weakened or fissured.
It is a constant process replacing all of our cortical bone over about ten
years, and all of our trabecular bone over two to three years.
Bisphosphonates stop the cells that break down bone from attaching to the
bone that needs to be replaced. In doing so they prevent cells that
remodel the bone from building it back up.
The pth medications, Forteo and Tymlos, increase the cells that build bone
and the cells that break down bone.
I'd rather have the newer, stronger, more vascular bone given the choice.
I watch my bone markers to ascertain that there is a balance between P1NP--
indicating growth, and CTX-- indicating breakdown.
I'm trusting those bone markers, and could be mistaken.
If the balance shifts, I might take a month or two of one of the weaker
bisphosphonates and return to Forteo.
Tymlos may be the stronger medication. I wouldn't object to a year of
Tymlos.
What to do can be difficult to decide. It was easy for me after a lot of
pubmed.
Some of us have too many side effects with Forteo or any of the medications.
Bless your choice.

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@gently
Thank you for your extensive feedback. I really have mandible exostosis. According to Denal RX 2026 guidelines it’s a risk for MRONJ. I think My dr wants Forteo or maybe I can convince Tymlos. So scared live alone. Suffer now on constipation , insomnia. Can’t have ongoing fatigue. And after a Forteo where do you go from there???

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ipg,
Tymlos is more medication than Forteo. They work in the same mechanism but are different molecularly. We are slightly more likely to have side effects with Tymlos in all the ways that hypercalcemia causes side effects. These effects include hair loss, weight gain and fatigue. Tymlos is 80mgc, Forteo 20mgc. And Tymlos is seen to add slightly more bmd than Forteo.
Both of these medications slow digestion. You might add or increase magnesium in you diet. Magnesium glycinate is though to be the best for digestion.
I use magnesium orotate because of speculation that it adds protection to blood vessels, but doesn't facilitate digestion.
Do you have clues about the cause of your fatigue/ insomnia? Folate/B12/iron. Have you lived alone for long.
MRONJ risk is very small with tori .05% to 1%. High risk numbers are from patients on monthly injection of zoledronate of bisphosphonates after cancer.
Some take raloxifene https://pmc.ncbi.nlm.nih.gov/articles/PMC6336572/ which has it own risks. MRONJ is so rare with raloxifene that it is excluded for the list of risky medications.
If your tori are large or bothersome, you could have them removed. Forteo would speed your recovery.
This process isn't easy, but you are taking all the right steps to make certain that to have the most advantageous results. I'm happy to talk about osteoporosis and happiest if it helps. I don't have a medical background, though keep questioning everything.

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Profile picture for gently @gently

ipg,
Tymlos is more medication than Forteo. They work in the same mechanism but are different molecularly. We are slightly more likely to have side effects with Tymlos in all the ways that hypercalcemia causes side effects. These effects include hair loss, weight gain and fatigue. Tymlos is 80mgc, Forteo 20mgc. And Tymlos is seen to add slightly more bmd than Forteo.
Both of these medications slow digestion. You might add or increase magnesium in you diet. Magnesium glycinate is though to be the best for digestion.
I use magnesium orotate because of speculation that it adds protection to blood vessels, but doesn't facilitate digestion.
Do you have clues about the cause of your fatigue/ insomnia? Folate/B12/iron. Have you lived alone for long.
MRONJ risk is very small with tori .05% to 1%. High risk numbers are from patients on monthly injection of zoledronate of bisphosphonates after cancer.
Some take raloxifene https://pmc.ncbi.nlm.nih.gov/articles/PMC6336572/ which has it own risks. MRONJ is so rare with raloxifene that it is excluded for the list of risky medications.
If your tori are large or bothersome, you could have them removed. Forteo would speed your recovery.
This process isn't easy, but you are taking all the right steps to make certain that to have the most advantageous results. I'm happy to talk about osteoporosis and happiest if it helps. I don't have a medical background, though keep questioning everything.

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@gently I really appreciate all your information sharing. May I ask how long you have been on this journey? You are helping me (and it seems so many others) who are just starting this way forward. Thank you!

REPLY
Profile picture for gently @gently

ipg,
Tymlos is more medication than Forteo. They work in the same mechanism but are different molecularly. We are slightly more likely to have side effects with Tymlos in all the ways that hypercalcemia causes side effects. These effects include hair loss, weight gain and fatigue. Tymlos is 80mgc, Forteo 20mgc. And Tymlos is seen to add slightly more bmd than Forteo.
Both of these medications slow digestion. You might add or increase magnesium in you diet. Magnesium glycinate is though to be the best for digestion.
I use magnesium orotate because of speculation that it adds protection to blood vessels, but doesn't facilitate digestion.
Do you have clues about the cause of your fatigue/ insomnia? Folate/B12/iron. Have you lived alone for long.
MRONJ risk is very small with tori .05% to 1%. High risk numbers are from patients on monthly injection of zoledronate of bisphosphonates after cancer.
Some take raloxifene https://pmc.ncbi.nlm.nih.gov/articles/PMC6336572/ which has it own risks. MRONJ is so rare with raloxifene that it is excluded for the list of risky medications.
If your tori are large or bothersome, you could have them removed. Forteo would speed your recovery.
This process isn't easy, but you are taking all the right steps to make certain that to have the most advantageous results. I'm happy to talk about osteoporosis and happiest if it helps. I don't have a medical background, though keep questioning everything.

Jump to this post

@gently
It really sounds that you are very knowledgeable. According to 2026 guidelines from Dental RX I have exostosis of the mandible, confirmed by an oral surgeon worried that if I start Forteo or Tymlos , make gains, unless I have a plan , I will lose all that I have gained. I am 70. Hrs transdermal patch and evista also have risks. Who is out there who have had “natural “ treatment? May I ask what you used and what your side effects were?

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Profile picture for ipg @ipg

@gently
It really sounds that you are very knowledgeable. According to 2026 guidelines from Dental RX I have exostosis of the mandible, confirmed by an oral surgeon worried that if I start Forteo or Tymlos , make gains, unless I have a plan , I will lose all that I have gained. I am 70. Hrs transdermal patch and evista also have risks. Who is out there who have had “natural “ treatment? May I ask what you used and what your side effects were?

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Well, ipg, I do have opinions. Knowledge is a little more elusive.
I knew I'd eventually have osteoporosis, had my first dexa at 50 and became
fascinated with our bones through pubmed. When Forteo was approved it was
a new medical method for dealing with the imbalance between cells that
break down bone and cells that build bone. Instead of stopping the break
down and the build up, Forteo increased both creating a stronger bone.
The method was new, the concept is as old as our bones.
My only experience is with Forteo, so I am very limited, especially
compared to other contributors on Connect. Even knowing I'd have
osteoporosis, I started a little late. I looked everywhere for a doctor
who wasn't insisting on two years of Reclast after Forteo. There wasn't
one. I started Forteo and continued looking for someone to switch to when
the two years were up. Much to my surprise at the two year mark, the
endocrinologist I see said he thought I should continue on Forteo. When I
asked for how long he said, "until your dexa T score is -1. I started my
fourth year in April.

REPLY
Profile picture for gently @gently

Well, ipg, I do have opinions. Knowledge is a little more elusive.
I knew I'd eventually have osteoporosis, had my first dexa at 50 and became
fascinated with our bones through pubmed. When Forteo was approved it was
a new medical method for dealing with the imbalance between cells that
break down bone and cells that build bone. Instead of stopping the break
down and the build up, Forteo increased both creating a stronger bone.
The method was new, the concept is as old as our bones.
My only experience is with Forteo, so I am very limited, especially
compared to other contributors on Connect. Even knowing I'd have
osteoporosis, I started a little late. I looked everywhere for a doctor
who wasn't insisting on two years of Reclast after Forteo. There wasn't
one. I started Forteo and continued looking for someone to switch to when
the two years were up. Much to my surprise at the two year mark, the
endocrinologist I see said he thought I should continue on Forteo. When I
asked for how long he said, "until your dexa T score is -1. I started my
fourth year in April.

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@gently
That’s great. I am turning 70. But I will wait a little. Going to the gym with a trainer short term and continuing with mk7 and d3. Can’t take calcium supplements so I drink and eat the food - almond milk is great. May I ask your age and side effects? Are you on the 40 dose. ? I suffer now from constipation controlled bp on meds, hypothyroidism and sleep disorder. I am extremely anxious and even now I am on weight watchers so I worry about the weight gain. Once your dexi is down to where she wants it what will you do to prevent remission?? Thanks so much

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Profile picture for btichy @btichy

Thank you for all the sharing of information. My last Dexa was -2.5 in the spine so not horrible and no fracture history or falls. However, my dental history is not good with bone loss (not a candidate for implants for that reason) and I'm expecting other extractions down the road. Because I'm so worried about the dental risk, the dr is suggesting Tymlos or Forteo for 2 years instead of Fosamax. But either one has to be followed immediately with a biphosphonate (she likes Reclast). So after 2 years of injections, I would be right back to the risk of jaw necrosis from the biphosphonate. Just doesn't seem prudent given a -2.5 Dexa. I don't want to be foolish either but my primary/gyn weren't all that concerned with a -2.4 for years. I know it's my choice so I'm thankful there's knowledgable people here to help sort it out.

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@btichy change of protocol for Tymlos. You can stay on it indefinitely. I use half a dose and I saw improvement in my DEXA scan.

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75 July first. Teriparatide (Forteo) is a 20mg dose. I haven't any side effects with Forteo. Well, I have noticed longer fingernails. You just have to clip them more often.
I have high CAC scores so am wary of calcium. And never let teriparatide fill my blood with calcium without taking magnesium orotate and K2 two hours before.
I don't think we ever get down to a -1 T score. I think he didn't want to offend me saying, until you "die."
Honestly, I'd take any of these medications (even Prolia) to prevent fracture, if there wasn't Forteo.
The weight gain is seen at the belly I've heard as much as 20lbs but usually around 5lbs.
Where do you think the anxiety originates.
You are very welcome.

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