ddMVAC neoadjuvant, has anyone experienced this type of chemotherapy ?

I had four cycles of adjuvant DDMVAC after RC in 2024-11. 2024-12 through 2025-03. Two cycles were delayed because of acute kidney injury (more likely as DDMVAC depletes white blood cells) and I was hospitalized. I also had cellulitis above my upper lip after DDMVAC 4. Aside from these events, I lost almost all my hair, I struggled with horrible constipation, nausea and fatigue.

I was scheduled for six but finished four cycles. The oncologist PA told me very few patients complete all six due to toxicity.

Thank you for that info. I hope you are doing well now.

Jaxfl, was an immunotherapy drug included in the adjuvant chemo ?

No. Those are only included in clinical trials for neoadjuvant treatment or confirmed visible disease in line two treatment after RC.

I am doing fairly well. Nivolumab gives me headaches, fatigue and also occasional diarrhea/abdominal pain and dry skin. But 95% better than DDMVAC.

Well hang in there, we are right behind you.

Thanks. One day at a time.

@skybolt, did your husband start dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin (ddMVAC)? How is he doing?

Hi, my husband did complete his first round (cycle) of ddMVAC. Everything went smooth and he was feeling pretty good for 2-3 days after treatment but felt fatigued with heartburn upset stomach for the next 5 days. Hoping the next round is similar and we will use the Rx meds like compazine and zofran to help with stomach issues.

Getting ready for round 3 next week. A lot of hair loss but not all and the loss seems to have stopped . Got the constipation under control with senokot 2 tabs daily at night. The burning in the mouth throat esophagus (from mucocitis )and queasiness is the biggest battle. Tiredness too but not terrible. He put in large wood boarders in the garden , planted numerous plants, I saw him on the ladder putting door protectors on the bird houses. He still goes to PT for a knee replacement. Hanging in there for sure.