Anyone else on Daraxonrasib (RMC-6236)?

There is much data out now on this drug. Its most likely strength of effectiveness will be taking it in unison with a type of existing chemo. It is not a cure but is a life extender for most that have taken it!

Please give any info on effectiveness of new REvolution drug vs chemo or other treatment options

@mcoplien I wish you all the best and prayers for you. It’s a Ricky road for sure.

@valerina30 Did 6 months of 5FU (with oxaliplatin and Iranitecan) in 2023 then has surgery to remove the tumor in the tail of the pancreas in 2/24, at that point Mike was stage I, removed spleen and 26 lymph nodes, good clean borders no sign of cancer.....except the presence of cancer in the nerve cells was positive... risk of recurrence. all scans and labs were good for a year, then CA 19-9 started to creep up... eventually was 4500 in Oct 2025 and recurrent PANcan found in mike's stomach, probably where the pancreas had been touching the stomach. Started Gem / Abrax in November 2025 - was working great until March, then CA 19-9 was back up, now at 11000. Waiting for the expanded approval to come thru. In the meantime Mike is back on 5FU/ ox / Iran... the side effects are rough. Hope he only needs it a couple more times before he can transfer to 6236!

Hello friends, as many know I was in an early trial of the revolution medicine drugs. From that, I have continued in a community of patients -some who have been on the drugs for 24 months or more! Many therapies have been tried and now prescribed for the skin issues. Some people experience irritation more than others. I am no longer a candidate for any KRAS trials but if someone is on it struggling with the skin issues pls reach out and I will pass along things now being prescribed so you can ask your doctors .

@valerina30
No all 3. 5FU, oxaliplatin and iranatecan.
Yes pain, mouth sores, gut pain. trying to bridge until 6236 is available. cancer is now in the stomach and liver.

@mcoplien Are you on just fu-5? I tried oral pills gave me to much pain so doctor wants to try low dose of fu-5 and no other combination.

@mcoplien
My oncologist who has done trials with 6236 says it also works on KRAS-wild genes, or cases where KRAS isn't mutated. I'm on 5FU now and Zolbetuximab (for peritoneal metastasis) and have about another month or so until 6236 should arrive for me.

@alanbeavfan Yes it is specific for the KRAS mutation. We are also waiting for it. My husband has stage four pancreatic cancer, reoccurring after he was stage 1 and had surgery and 6 month of 5FU. Gemcitabine/Abraxane stopped working, so he is back on 5FU while we wait for the approval.

Thank you to all who commented and sent hugs. I did reach out to Rev.Med for clarification but they responded with the same info that is on the website. Your oncologist has to submit a request and after that it still seems rather vague. Hopefully the requests will be honored and there will be enough medication to meet the demand. My brother is not doing well and I hope he will be able to take advantage of this drug. At this point a couple of months is a long time. My support goes out to all who are waiting and hoping, I guess that is all we can do at this point. Thanks again for the responses