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Creatine Benefits for Epilepsy

Posted by Chris Gautier, Volunteer Mentor @santosha, Mar 28, 2025

Good Morning Everybody!
Recently, while researching creatine for another purpose, I discovered some medical studies regarding its potential benefit for epilepsy patients. Is anyone familiar with it? If so, have you spoken with your neurologist about it and could you share your experiences? I take creatine usually on days of much body workout, such as tennis. My doctor said it is safe to use.
Thank you!
Chris (@santosha)

Interested in more discussions like this? Go to the Epilepsy & Seizures Support Group.

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alla1967alla | @alla1967alla | May 12 12:38pm
In reply to @santosha "I share here a summary of benefits of creatine for epilepsy I learned through some research..." + (show)
Profile picture for Chris Gautier, Volunteer Mentor @santosha

I share here a summary of benefits of creatine for epilepsy I learned through some research on the internet:
Benefits of Creatine for Epilepsy
Creatine has been studied for its potential benefits in managing epilepsy, particularly in relation to seizure control and brain health. Here are some key points regarding its effects:
Anticonvulsant Properties: Research indicates that creatine may possess anticonvulsant properties. For instance, studies have shown that acute administration of creatine can improve mitochondrial function and protect against seizures induced by certain chemicals, suggesting a protective role in seizure activity.
Enhanced Energy Production: Creatine supplementation can increase the phosphocreatine:creatine energy-store ratio in the brain. This enhancement in energy production may improve the efficacy of dietary interventions, such as the ketogenic diet, which is often used in managing drug-resistant epilepsy in children

.
Neuroprotective Effects: Creatine has been shown to protect against neurotoxicity in certain models, which may be beneficial for individuals with epilepsy. By increasing energy availability in neurons, creatine could help mitigate some of the neurodegenerative processes associated with chronic seizure activity.
Clinical Observations: Anecdotal evidence from individuals with epilepsy suggests that creatine may help in preventing seizures. Some users have reported positive effects when combining creatine with their existing treatment regimens.

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@santosha thank you so much for sharing.

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laura | @laura1961 | May 13 7:42pm
In reply to @cathy5161 "Experience with peptide protocol, tailored to your situation?" + (show)
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Experience with peptide protocol, tailored to your situation?

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@cathy5161 how are you doing on both? I was about to look into the peptide protocol & have just finished my 1st container of Creatine. I have only just upped 1tsp to 2tspn's every morning.

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laura | @laura1961 | May 13 7:55pm
In reply to @bucsfan22 "True but if we don’t find ways to beat it or help ourselves nobody else will...." + (show)
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True but if we don’t find ways to beat it or help ourselves nobody else will. You have to stand up and fight back against all of this nonsense!

If I find a cure I’m gonna sell my treatment plan. Chase to the moon essentially. Lol

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@bucsfan22 I followed what the Drs have told me & ended up worse off. That has been with seizures along with Osteoporosis. The meds for seizures caused by a TBI 20 years ago took 2 seizures a year up to around 22 -24 a year. I wish I had done my research into keto before the meds which i stopped in 2012.

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Chris Gautier, Volunteer Mentor | @santosha | May 18 11:39am

Good Morning!
I'd like to share some updates on my creatine intake since I first brought this topic to the group.
The most noticeable benefit so far has been increased energy and improved performance during my tennis and Pilates sessions, something my teachers have actually remarked on. That said, I've been taking only two scoops (6 g) daily, which is still considered a low dose. At this level, the muscles absorb most of the creatine. The potential cognitive benefits that several studies have highlighted likely require a higher daily intake, something I haven't yet had the chance to explore fully with my neurologist and general practitioner.
From what I've read in recent research, brand quality matters significantly. The gold standard is Creapure, a certified creatine monohydrate that guarantees purity above 99.9%, no harmful byproducts, and consistent quality across batches.
A couple of questions for the group: Is anyone here using a Creapure-certified brand? And has anyone been taking 10 g or more daily? If so, I'd love to hear about your experience, especially any effects you've noticed on cognition or seizure management.
Thank you!
Chris

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Chris Gautier, Volunteer Mentor | @santosha | May 18 11:41am
In reply to @alla1967alla "@santosha thank you so much for sharing." + (show)
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@santosha thank you so much for sharing.

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My pleasure @alla1967alla !
Chris

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