concerned over rising creatinine level.

Posted by rans @rans, Dec 11, 2018

Labs showed level increased from 1.5 to 1.7. All my other numbers were ok. GP took me off my BP ( lisinopril ) med for one week and then retest.( pending

@rans, interesting. I was recently hospitalized for exacerbation COPD from a cold virus and my cr was a little higher than it was when drawn at last doc visit. My BUN and cr are elevated anyway (stage 3 CKD.) I, too take Lisinopril. Emailed some concerns about this to my doc, who had his office call to schedule appointment next week to discuss. Also, I take insulin for diabetes and a couple of other meds I need (a statin and an anti-depressant) interfere with insulin absorption. I feel like I'm always between a rock and a hard place, including renal diet vs diabetic diet. Very frustrating. Usually I have a positive attitude and stay cheerful while doing everything I can to balance it all but lately am feeling overwhelmed.

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Stage 4… I was taken off lisinporil about 8 months ago by my nep. I didn’t see much improvements in my labs after stopping, but, apparently it isn’t a good drug for kidneys.. My last lab (10/18)Crea 1.85, GFR 26.87. Improved a little after starting renal diet (9/18 Crea 1.96, GFR 25)…I go back 12/26 so I’m praying my diet changes will at least hold me at this level….my NA, K, P, Glucose & calcium were all within boundaries. Most were right in middle…dang Creatinine and GFR my issues. My GP had to increase my beta blocker because my BP just wouldn’t go down. I’m still “feeling” problems with my heart so, we will adddress when I see him. I’m concerned I’ll hv a darn heart attach before my kidneys fail…after reading, I know that’s like a 90% chance. Good luck and let’s keep posting….thank you!

Liked by cehunt57

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@rans A while back, I was receiving treatment for kidney problems. I had my blood tested for creatinine every week or two. My creatinine level went up and down from week to week. I don't know if that's normal or not. Personally, I would be happy if the change in my creatinine level was only 0.2

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@sissieann

Stage 4… I was taken off lisinporil about 8 months ago by my nep. I didn’t see much improvements in my labs after stopping, but, apparently it isn’t a good drug for kidneys.. My last lab (10/18)Crea 1.85, GFR 26.87. Improved a little after starting renal diet (9/18 Crea 1.96, GFR 25)…I go back 12/26 so I’m praying my diet changes will at least hold me at this level….my NA, K, P, Glucose & calcium were all within boundaries. Most were right in middle…dang Creatinine and GFR my issues. My GP had to increase my beta blocker because my BP just wouldn’t go down. I’m still “feeling” problems with my heart so, we will adddress when I see him. I’m concerned I’ll hv a darn heart attach before my kidneys fail…after reading, I know that’s like a 90% chance. Good luck and let’s keep posting….thank you!

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@sissieann Asked my neph about Lisinopril, she said stay on it for now even though ACE inhibitors aren't kidney-friendly. When I'm feeling better I want to explore alternatives. Cr was 1. 4 in hospital this Dec, before that it was 1.41 in August, same value in Nov. @marvinjsturing, Down 1/100th of a point isn't exactly the progress I had hoped for. I guess some fluctuation in cr is normal, or so I'm told.

Liked by cehunt57, sissieann

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@kamama94

@rans, interesting. I was recently hospitalized for exacerbation COPD from a cold virus and my cr was a little higher than it was when drawn at last doc visit. My BUN and cr are elevated anyway (stage 3 CKD.) I, too take Lisinopril. Emailed some concerns about this to my doc, who had his office call to schedule appointment next week to discuss. Also, I take insulin for diabetes and a couple of other meds I need (a statin and an anti-depressant) interfere with insulin absorption. I feel like I'm always between a rock and a hard place, including renal diet vs diabetic diet. Very frustrating. Usually I have a positive attitude and stay cheerful while doing everything I can to balance it all but lately am feeling overwhelmed.

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Like you I have many issues to consider as well. Triple by pass 3 years ago so I'm a little nervous about going off meds. Dr. said I should be ok for a week.

Liked by cehunt57

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@marvinjsturing

@rans A while back, I was receiving treatment for kidney problems. I had my blood tested for creatinine every week or two. My creatinine level went up and down from week to week. I don't know if that's normal or not. Personally, I would be happy if the change in my creatinine level was only 0.2

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I probably wouldn't be as concerned except it puts me in that stage 3b catagory. Hopefully it will be down next week

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@kamama94

@sissieann Asked my neph about Lisinopril, she said stay on it for now even though ACE inhibitors aren't kidney-friendly. When I'm feeling better I want to explore alternatives. Cr was 1. 4 in hospital this Dec, before that it was 1.41 in August, same value in Nov. @marvinjsturing, Down 1/100th of a point isn't exactly the progress I had hoped for. I guess some fluctuation in cr is normal, or so I'm told.

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Hope so.

Liked by cehunt57, sissieann

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Things to be concerned about keep popping up, don't they. I, too, take Lisinopril. Shall check this out, too.

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@kamama94

@sissieann Asked my neph about Lisinopril, she said stay on it for now even though ACE inhibitors aren't kidney-friendly. When I'm feeling better I want to explore alternatives. Cr was 1. 4 in hospital this Dec, before that it was 1.41 in August, same value in Nov. @marvinjsturing, Down 1/100th of a point isn't exactly the progress I had hoped for. I guess some fluctuation in cr is normal, or so I'm told.

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My Cr was 3.62 in August. Last week it was 3.67. I also am on Lisinipril.

Liked by cehunt57, sissieann

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@marvenjsturing. Realized my nephrologist reduced my Lisinopril from 10 mg to 5 mg. Told me it was because of a change in my blood pressure – now, I'm not so sure. Anyhow, after almost a year, bp is 140/68. Cr is 1.0+/-. Think you might want to question your doctor. Hope this helps.

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Thanks, I will. like your numbers.

Liked by cehunt57

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@trishanna Recent round of steroids and inhalers for exacerbation of COPD elevated my B/Ps in spite of the Lisinopril. Now that I'm better and will finish meds tomorrow, hoping it will come back down and I can reduce the Lisinopril. Very frustrating to have conditions whose treatments conflict with one another, isn't it?

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To all with kidney problems who are on Lisinopril, I hope something can be worked out for you. I like @kamama94 diet suggestions, but there are no easy answers. My diet is already limited due to the IBS, so who knows if that's accidentally been a help. I'm so reluctant now to take any meds!!!!

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@trishanna

To all with kidney problems who are on Lisinopril, I hope something can be worked out for you. I like @kamama94 diet suggestions, but there are no easy answers. My diet is already limited due to the IBS, so who knows if that's accidentally been a help. I'm so reluctant now to take any meds!!!!

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Does anybody know where we can get expert documentation of the kidney problems caused by Lisinopril? I'm now on a 40mg daily dose of Lisinopril, and I have been on it for years — starting with 20mg daily dosage about 15 years ago. My hypertension has always been under treatment by a nephrologist, and all three of them are well known and highly respected. Not once have I received any advice that Lisinopril might cause kidney problems, and so far as I know, I have no symptoms attributable to it.

Liked by cehunt57

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@predictable

Does anybody know where we can get expert documentation of the kidney problems caused by Lisinopril? I'm now on a 40mg daily dose of Lisinopril, and I have been on it for years — starting with 20mg daily dosage about 15 years ago. My hypertension has always been under treatment by a nephrologist, and all three of them are well known and highly respected. Not once have I received any advice that Lisinopril might cause kidney problems, and so far as I know, I have no symptoms attributable to it.

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@martin Jensen and everyone wondering about Lisinopril:

I've read and been told that ACE-inhibitors like Lisinopril can protect the kidney from renal hypertension (relieving glomerular pressure by lowering blood pressure, especially in diabetics.) But it also can decrease GFR because it blocks a protective mechanism which occurs in the kidney to maintain GFR.

So it seems to be a tossup – protect the kidney and improve function by controlling blood pressure vs protect the kidney's GFR status which MIGHT be impaired by the blood pressure med.

This is not medical advice or diagnosis, just my opinion based on my nurse's training as well as on fairly recent research done on my own.

I'm guessing my neph and primary both told me to stay on Lisinopril for now because they believe the benefits of lowering my blood pressure outweigh the risks of lowering GFR, especially since my GFR is above 30.

I'm also guessing that if my GFR declines too much we will have to seek alternatives.

Once again, these are just my own guesses and opinions based on a small amount of research.

Here are some websites with more information on the subject:
https://www.mdedge.com/clinicianreviews/article/134719/nephrology/when-discontinue-raas-therapy-ckd-patients
tmedweb.tulane.edu/pharmwiki/doku.php/ace_inhibitor_pharmacology
https://universityhealthnews.com/topics/heart-health-topics/3-ace-inhibitor-side-effects-should-you-seek-out-alternatives/

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