Common antibiotics for BE exacerbation.

Posted by spider109 @spider109, Aug 6 4:26am

I have Bronchiectasis which has been termed “pretty significant” by a Mayo Jax Pulmonologist. I just had an exacerbation, and was prescribed the antibiotic Doxycycline 100mg x2 daily x7 days. It worked really well. I know it’s up to the Doctor but can anyone tell me other antibiotics they have been prescribed that have worked well. We all know antibiotics build up resistance over time and over use, and that we’re all different, but there must be some sort of protocol or order the Dr’s try different things. I’ve been told by my Pharmacist that some Dr.’s will rotate between different antibiotics so there’s less of a chance to buildup resistance to a certain one. Sounds like a good idea. Thank-you for any information. I have never been diagnosed with MAC.

Interested in more discussions like this? Go to the MAC & Bronchiectasis Support Group.

@irenea8

I had a very serious exacerbation about 4 years ago but nothing could be identified from my sputum. My pulmo felt based on the look of the sputum that Augmentin would be a good option. He was right. But I had to take it for 4 weeks. One and a half years later I was feeling enough exacerbation to be prescribed Augmentin again. Took it for 2 weeks but it did not help that time. That is when I suggested to my pulmo that perhaps I had Pseudomonas (which does not respond to Augmentin). Turns out I was right. I never realized that the sputum test for Pseudomonas was a specific test. And I wish my pulmo had ordered that test sooner.

Jump to this post

My understanding is that screening for Pseudomonas aeruginosa is with the standard sputum culture. Now that you raise this as a potential issue I will double check with pulmonary and report back!

My standard sputum culture tests for:
Legionella
Fungus
Respiratory including gram stain (this is where I thought pseudo would show up)
AFB stain
another one after the stain for NTM (EPIC hard to read, don't like!)

REPLY
@narelled23

I didn't realise that was a specific test for pseudomonas either. Thank you.

Jump to this post

I didn't either. Here's what Mayo states;
This culture is specifically designed and utilizes conventional and additional selective media (compared to non-CF respiratory cultures) to isolate bacteria commonly associated with pulmonary disease in patients with CF.

CF=cystic fibrosis

REPLY
@scoop

My understanding is that screening for Pseudomonas aeruginosa is with the standard sputum culture. Now that you raise this as a potential issue I will double check with pulmonary and report back!

My standard sputum culture tests for:
Legionella
Fungus
Respiratory including gram stain (this is where I thought pseudo would show up)
AFB stain
another one after the stain for NTM (EPIC hard to read, don't like!)

Jump to this post

Looked up this info. Here is what Mayo states about a CF culture;

This culture is specifically designed and utilizes conventional and additional selective media (compared to non-CF respiratory cultures) to isolate bacteria commonly associated with pulmonary disease in patients with CF.

REPLY
@scoop

My understanding is that screening for Pseudomonas aeruginosa is with the standard sputum culture. Now that you raise this as a potential issue I will double check with pulmonary and report back!

My standard sputum culture tests for:
Legionella
Fungus
Respiratory including gram stain (this is where I thought pseudo would show up)
AFB stain
another one after the stain for NTM (EPIC hard to read, don't like!)

Jump to this post

At U of IA it seems to be a distinct test. Maybe it just depends on the lab and the kind of tests they do??

REPLY

There seem to be events that are called BE exacerbations which can be caused by other things than pseudomonas etc and these events can need treatment with antibiotics. Not all bacteria is picked up in a sputum test. I think sometimes the issues get confused.

REPLY
@irenea8

At U of IA it seems to be a distinct test. Maybe it just depends on the lab and the kind of tests they do??

Jump to this post

Pulmonary confirmed for me that my sputum cultures are screened for pseudomonas. Maybe your lab does something different as standard? Then again, U of IA sounds like a large university teaching facility and maybe they are on to something? I plan to pursue with my care team to double check. Thanks for mentioning it!

REPLY
@scoop

Pulmonary confirmed for me that my sputum cultures are screened for pseudomonas. Maybe your lab does something different as standard? Then again, U of IA sounds like a large university teaching facility and maybe they are on to something? I plan to pursue with my care team to double check. Thanks for mentioning it!

Jump to this post

As Liz said an exacerbation can be caused by many things but just wanted to mention my experience of taking one of the standard broad spectrum antibiotics usually prescribed (Augmentin) and the fact that it did not work and what that might mean. I think everyone should make sure they have been screened for Pseudo since catching it early is so crucial and since developing it in the chronic form is so terribly impactful to ones health. And in my case a special test had to be ordered which I was not aware of. I had assumed I was screened for "everything" with the usual sputum testing. Best to just check it all out with your Pulmo.

REPLY
@scoop

@cwal and what do you do if the culture is negative but you still has symptoms of an exacerbation? Do you chalk it up to colonization?

Jump to this post

Not me, if the culture is negative, I chalk it up to a virus. There are thousands circulating, because our damaged lungs are susceptible to bugs that never bother others. For example, I know that "just a cold" inevitably leads to bronchitis, before 7% saline that inevitably led to pneumonia.

In that case, my pulmonologist has me double my nebs for 7 days, and if it is still not gone we resort to a wide-spectrum antibiotic (and possibly another sputum culture.) The ID doc (in the same practice with her) likes this approach. Both are in the camp of "fewer antibiotics. fewer times, helps avoid more drug resistant bacteria."

Does anyone else have a doc who does conservative treatment first in an exacerbation?

REPLY
@liz440

There seem to be events that are called BE exacerbations which can be caused by other things than pseudomonas etc and these events can need treatment with antibiotics. Not all bacteria is picked up in a sputum test. I think sometimes the issues get confused.

Jump to this post

BE simply refers to the associated disease called Bronchiectasis. I’m not trying to insult your knowledge I just wanted to clarify for the group. Thank you.

REPLY
@cwal

I didn't either. Here's what Mayo states;
This culture is specifically designed and utilizes conventional and additional selective media (compared to non-CF respiratory cultures) to isolate bacteria commonly associated with pulmonary disease in patients with CF.

CF=cystic fibrosis

Jump to this post

Could be an insurance thing.

REPLY
Please sign in or register to post a reply.