Ask your doctor if Tacrolimus is a substitute anti rejection drug.

@mmr1984 My husband had digestive issues, especially when he started cellcept before his kidney transplant. The doctor prescribed him omeprazole and since starting that and having the transplant he has not had any issues. Tacrolimus is not a substitute, my husband must take both of those meds now. If your issues worsen or even now, let your transplant team know. I hope you get some relief.