Can anyone share their experience with Pluvicto?

I started this journey 2 years ago and have had 6 rounds of chemo and have been on nebqua and lupron for this time. Now it seems it quit working so I am now taking once a day orgovyx, nubqua, and am going to start pluvicto next week. I know what chemo was like for a few days after a treatment, but wonder what to expect with an infusion of pluvicto every 6 weeks. Anyone had this treatment, and what to ecpect?

Some people have some major side effects from Pluvicto, most don’t. I have heard at least 5 people talk about their experience, In some cases they had to have more time between doses because of the side effects.

I saw a webinar where they discussed a person who lit up the Pet scan With metastasis from head to Legs. He had one Pluvicto Treatment and it almost cleared his pet scan, But his side effects were so bad that he could not take any more treatments

Be aware that it works really well for 33% of people OK for 33% of people and not at all for 33% of people.
If you have certain genetic issues, either hereditary or somatic, it can affect how well Pluvicto Works. You can ask for a somatic test before doing Pluvicto To find out if you’ve got Genetic changes Due to the cancer.

If you have BRCA2 or ATM It seems to work better. If you have RB1, PTEN or TP53 They are Pluvicto resistant.

Here is a very long discussion from many people about their experience with Pluvicto
https://connect.mayoclinic.org/discussion/can-anyone-share-their-experience-with-pluvicto/

@smc24
i am just about to start pluvecto. How long have you been on it. i'm wondering how much time it might buy me. Kinda scared. was diagnosed 0ct2024 looking to keep myself in this world as long as i can only 56.

Hey im just about to start pluvecto. Im 56years old and was wanting to hear how long people have been on pluvecto. im kinda scared how much extra time this treatment might give me, not ready to go yet, so if anyone has some encoraging Pluvecto stories please respond.

I was diagnosed stage 3 metastatic prostate cancer in 2014. Had all the typical surgeries, chemo, drugs, orchiectomy, targeted beam radiation, etc. Those treatments kicked the can down the road for a few years, but entered stage 4 in 2020. I became a clinical trial patient in 2021 for Norvartis Pharmaceutical's Pluvicto at U. of Chicago Medical Center, ending in spring 2022 with remarkable results.
The cancer had a slight uptick in late 2024 and (through very, very special arrangements) I started another 6 rounds of Pluvicto at that time. Again, it is working remarkably well. I paused after 4 of the (2nd) 6 treatments to save the remaining 2 later, if needed. Side effects were extremely minimal, experiencing some late treatment fatigue and the obvious temporary radiation for 3 or so days after each treatment, but no nausea.
As of today, 2/19/26, my PSA is still below 0.008 and other indicators, i.e. tumors, bloodwork, etc. are very good. I remain a very active 74 year old and live a normal lifestyle.
Thus, for me, I was at the right time, right place, right connections and believe it was the wisest decision I could have made. I have nothing but encouragement.
Stay in touch.

I have had two injections of Pluvicto
And have some side effects, dry mouth, fatigue, and some GI problems but nothing serious
My PSA would not go down until I started Pluvicto
My PSA went from 20 to 1.1 and five weeks treatments are every six weeks

This sounds promising