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Can anyone share their experience with Pluvicto?
My 85 year old dad has prostate cancer that has metastasized to his bones. Zytiga is no longer effective. He is considering Pluvicto. I would appreciate input from those who have used Pluvicto.
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Doing Pluvicto A second or third time is not unusual. In Australia, it has become more common. You should ask about the possibility of having it a second time. I’m surprised that they pulled you off chemo after two different tries and the PSA not dropping below 13. I’ve heard that from many people, but when they continue with it, it does work for some of the people. I know people have had their PSA rise after having a second or third chemo session, Only to have a drop After later sessions.
Ask your doctor about it, Would it make sense to try it again?
After Xtandi no longer worked and after my husband's first Pluvicto, his PSA rose to over 1,300. In a telemed appointment this morning, the nuclear medicine specialist suggested we consider hospice. I was shocked. A second Pluvicto treatment is scheduled in two weeks, and neither my husband nor I are ready to give up. He is often tired and his legs are weak, but he gets up every morning, comes down a flight of stairs and eats breakfast. Watches a lot of tv, plays his guitars and spends his days like many retired people do. I think we should at least wait until we're sure Pluvicto isn't reducing the cancer at all before giving up treatment other than pain meds. He doesn't need a hospital bed and/or visiting nurse. What do you other cancer patients think?
Some people have some major side effects from Pluvicto, most don’t. I have heard at least 5 people talk about their experience, In some cases they had to have more time between doses because of the side effects.
I saw a webinar where they discussed a person who lit up the Pet scan With metastasis from head to Legs. He had one Pluvicto Treatment and it almost cleared his pet scan, But his side effects were so bad that he could not take any more treatments
Be aware that it works really well for 33% of people OK for 33% of people and not at all for 33% of people.
If you have certain genetic issues, either hereditary or somatic, it can affect how well Pluvicto Works. You can ask for a somatic test before doing Pluvicto To find out if you’ve got Genetic changes Due to the cancer.
If you have BRCA2 or ATM It seems to work better. If you have RB1, PTEN or TP53 They are Pluvicto resistant. I don’t know if these are the only hereditary changes that cause Pluvicto to work much better or more poorly.
If you have not had a hereditary test, I can give you the Website of a Study where you can get it for free.
My situation is similar. I completed 6 Pluvicto treatments Feb.2024 and psa stayed around .2 for 11 months.
Now psa is 4.6 which is doubling each month.
MO says I'm in uncharted waters and is still not sure of treatment options.
I can not afford the cost of re-treatment of Pluvicto and FDA has not approved beyond six treatments.
Anyone with treatment ideas is appreciated.