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Can anyone share their experience with Pluvicto?

Posted by vcash @vcash, Apr 22, 2024

My 85 year old dad has prostate cancer that has metastasized to his bones. Zytiga is no longer effective. He is considering Pluvicto. I would appreciate input from those who have used Pluvicto.

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foamhand | @foamhand | Feb 11 5:50am
In reply to @smc24 "I was a clinical trial patient for Pluvicto Nov. 2021-May 2022, U. Of Chicago, standard 6..." + (show)
@smc24

I was a clinical trial patient for Pluvicto Nov. 2021-May 2022, U. Of Chicago, standard 6 treatment 6 weeks apart. It was a last resort having been through most all standard protocol of surgeries, drugs, radiation, etc. I am stage 4 metastatic castration-resistant. At that time, data showed an typical 11-15 months life extension. My PSA dropped to almost undetectable, PET scans showed many tumors disappeared and others greatly reduced in size. I had a day or two of feeling mildly sick after each treatment, but very, very tolerable. It definitely kicked the can down the road.
Sept. 2024, PSA has shown slight rise and tumors are growing again. Having ruled out other options for one reason or another, many of which I have had, I have started the Pluvicto 6 treatments for the second time, completing the first (#7) three weeks ago. I follow the same post treatment isolation requirements due to the radiation. I had a week of mild upset stomach and annoying headache this time. In three weeks after the 2nd treatment (#8), I"ll have another PET scan to see how the tumors are doing. The PSA has stablized extremely low.
Thus, FOR ME, it saved my life once, so the doctors and I see this as the best option, and I'm doing it again. There is no published data on a patient going through these treatments twice.
Since Pluvicto finds and treats virtually every prostate cancer cell no mater were it is located in the body, I consider it an excellent option for a metastatic patient.

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I received the first 6 Pluvicto infusions from Aug 2023 to April 2024 with very good results until Dec 2024 PSMA PET scans showed slight progression. I'm also approved for an additional 6 doses and got #7 last week. Same effects as always, slight flu like feeling fo 3 days but good now.
I'm younger (64) and have been fighting this already for 11 years , diagnosed in 2014 already inoperable stage 4 metastatic to pelvic region. I belong to several Pluvicto support groups and from what I've read on those, IMHO...non medical opinion, Pluvicto is good for people in reasonably good overall health. More elderly and frail people taking Pluvicto seem to have had bad outcomes, having to stop early and going downhill fast afterward, or dying during treatment. I think some good base overall health guidelines need to be established to screen prospective patients, not just blood work. Body condition and mass etc. need to be considered. They are starting Pluvicto earlier on, before chemo in some cases which may be a good idea as someone might not be dangerously "run down" from other treatments. ALWAYS discuss this with your doctor. I am not medically trained and my comments are purely from personal observations and reading. Best wishes to all.

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Moderator
Colleen Young, Connect Director | @colleenyoung | Feb 12 5:49pm
In reply to @sillyoyster "Hi robert, Can pluvicto be infused with a butterfly needle?" + (show)
@sillyoyster

Hi robert, Can pluvicto be infused with a butterfly needle?

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@sillyoyster, were you able to ask your cancer team about these important questions about radiation exposure? Can the butterfly needle be used for you for Pluvicto infusions or how are they making delivery easier for your viens?

REPLY
sillyoyster | @sillyoyster | Feb 13 10:54am

not yet. That's why I posted the question?

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