Can anyone share their experience with Pluvicto?

@michelegiger, this must be so hard to see you partner go through not one, but two tough cancers - like you said - a nightmare.

Did you and your husband decide to continue treatment and start Pluvicto? How are YOU doing?

I was a clinical trial patient in original 2021-22 (Norvartis Pharmaceutical PSMA 617 Lu177), now Pluvicto, trial. It worked wonders for me. Eight or so years of other treatments prior to 2021 kicked the problem down the road, but no longer worked. Side effects were much less than chemo and other treatments I've received. If your situation is "to that stage" and you meet the requirements, I recommend it. Stay in touch

Older gent here who has progressed through chemo, standard radiation, a variety of scans (MRI, PET, etc) and I just have my first Pluvicto injection at the beginning of May '25. Looking for folks who might be able to shed light on how the Pluvicto injections have worked/not worked and what side effects you've had to work through. I'm on multiple opioids and a steroid to control pain—as long as I maintain the regimen, things seem reasonable. Lose track of where I am in the day and things go sideways rapidly.

Thanks

You have to realize that Pluvicto is real successful for about 1/3 of people works OK for about 1/3 and it doesn’t work at all for 1/3 of people.

There are genetic issues, however. You want to make sure to get a hereditary genetic test as well as somatic genetic test to see if you have any of these genetic anomalies.

Pluvicto genetic issues
RB1, PTen, TP53 are Pluvicto resistant
ATM & BRCA work better with Pluvicto

Did you got a hereditary, genetic test. You can get the test free at the below site as long as you live in the United States. Don’t Pick the option for your doctor to be involved. They won’t send you the kit until they speak to your doctor. A geneticist will call you to discuss the results in abouft three weeks.

Prostatecancerpromise.org

I am 86 and have been fighting prostate cancer since 2014.
My PSA started out at 80 and 6 weeks after the 1st treatment of Pluvicto it was 40. This is the best result I have ever had. Sure, beats the hell out of chemo. I will have the results of the 2nd treatment on May 12.
My only side effect I have had is diarrhea or constatation (not at the same time) during the 1st week after the infusion.
I am now back out on the golf course playing twice a week.

Best Wishes
Willis Beavers

79, been thru chemo, ADT,and now one Pluvicto treatment. I also have IPF (Idiopathic Pulmonary Fibrosis) and had no real 'reactions' to the first Pluvicto injection.........but as the six week interval progressed, my level of 'tiredness' and lack of energy increased almost daily. I am not bedridden, but my breathing has become more labored and I have diminished energy (which was low pre-Pluvicto). My doc cancelled my 2nd Pluvicto treatment which was scheduled for 2 May (yesterday) based on my symptoms, and we all agree I need to see Pulmonologist for tests on lungs - question is has the Pluvicto accelerated the growth of the fibrosis? Complicated for sure, but I'm optimistic overall.

I'm in year 5 of my Advanced Prostate Cancer. First 3.3 years my PSA was on a steady decline from 118-to-1.8. Since then its been on a steady rise now its 12.4. Started Pluvicto on January 27, just had my 3rd shot and my PSA went up again.
For me Pluvicto offered something hopeful. Is it working I don't know? I meet with my oncologist Wednesday all we'll go from there. My oncologist is fun, caring, a really good communicator. We discussed the pros and cons of Pluvcito going in. So, I am still minded about this treatment.

Be aware that 1/3 of people have really good results from Pluvicto, 1/3 Respond OK and 1/3 get nothing from it.

Pluvicto genetic issues
RB1, PTen, TP53 are Pluvicto resistant
ATM & BRCA work better with Pluvicto

Have you had a hereditary Test or a somatic test? It would be good to have both before having Pluvicto So you can see if you have a genetic conflict.

Some people have some major side effects from Pluvicto, most don’t. I have heard at least 5 people talk about their experience, In some cases they had to have more time between doses because of the side effects.

I saw a webinar where they discussed a person who lit up the Pet scan With metastasis from head to Legs. He had one Pluvicto Treatment and it almost cleared his pet scan, But his side effects were so bad that he could not take any more treatments

Hi Jeff
I think that I am one of the lucky ones in the top 1/3.
I just completed infusion # 3 with minimal side effects,
My PSA has dropped like a rock, started at 78 dropped to 39 then to 12.
I am going to talk to my oncologist about pausing treatments 4,5, & 6 . Save some ammunition for went
the PSA goes back to 80.
The Best of Luck
Willis Beavers

Interesting Pluvicto/PSA encounter after shot #3. My PSA went flying from 7 to 12. Just like that my hope deflated awaiting arrival of my PSA depression. My oncologist recommended stoping Pluvicto, and go right to scans and XTANDi. After he consulted with my Radiation Oncologist, Nuclear Oncologist, and other Oncologist, he/we/they came to the conclusion this looks like a PSA Flare. PSA Flares happen, the recommendation for the docs was to take one more injection, wait two weeks, do a Pet-Scan, and Bone scan and take it from here. This works well for me.

Anyone else have a PSA Flare-up while on Pluvicto?