Anyone take new drug Camzyos (mavacamten) for HCM?

I have been on Camzyos 5 mg. 6 days now and have no improvement. I was on Disopyramide. I took naproxen and Dramamine for a migraine yesterday and had a bad reaction to those two drugs and was not warned about them. Has anyone else had a reaction to other drugs while on Camzyos?

I was taking it before I started Camzyos. It was one of the things my doctor tried before he learned about Camzyos. He started me at 25 mg, then bumped me up to 50 and then 100. I got very dizzy when he upped my dose to 100mg. So he brought me back down to 50mg. I have not had any negative reactions taking both. We discussed if I am going to continue taking it and for now I am. I take it in the morning with Camzyos and Atorvastatin. He said for now he wants me to continue with the Atorvastatin as well.

My appointment ran 2 hours. My LVOT is 6 now, before taking Camzyos it was 12 resting and between 100 and 140 during my stress test. My ejection fraction is 55 to 60. It was 65 to 70 before I started the med.

I am still experiencing shortness of breath, fatigue, intermittent angina, and a high heart rate (in the 90), averaging in the high 70s even when I am sleeping. So he ordered a stress echo since the normal limited echo does not show an obstruction; but, upon excretion, there is a severe obstruction. Probably why I have been misdiagnosed for years.

I am in my 7th week. He is still hopeful that Camzyos will start to give me some relief. He talked about putting me on a very low dosage of Metoprolol to slow down my heart rate. We decided to wait until after my stress echo. I am still at 2.5mg of Camzyos. Lost the battle, but hopefully I win the war.

I am staying positive. I am going to Austin today for a Ladies weekend. All of the activities are inside. It will be interesting to see how much I can do.

Hanging in there everyone!

Thank you @kelliw. You feedback is always so helpful. Did you experience any negative reactions to taking both. Were you taking it before you started Camzyos?

My appointment ran 2 hours. My LVOT is 6 now, before taking Camzyos it was 12 resting and between 100 and 140 during my stress test. My ejection fraction is 55 to 60. It was 65 to 70 before I started the med.

I am still experiencing shortness of breath, fatigue, intermittent angina, and a high heart rate (in the 90), averaging in the high 70s even when I am sleeping. So he ordered a stress echo since the normal limited echo does not show an obstruction; but, upon excretion, there is a severe obstruction. Probably why I have been misdiagnosed for years.

I am in my 7th week. He is still hopeful that Camzyos will start to give me some relief. He talked about putting me on a very low dosage of Metoprolol to slow down my heart rate. We decided to wait until after my stress echo. I am still at 2.5mg of Camzyos. Lost the battle, but hopefully I win the war.

I am staying positive. I am going to Austin today for a Ladies weekend. All of the activities are inside. It will be interesting to see how much I can do.

Hanging in there everyone!

You are lucky your doctor is so involved. A senior researcher on Camzyos acknowledged that it is important to have an experienced sonographer to do the echo. Because w HOCM there is contamination of the image and it’s hard to get a good reading. Great that your doctor came in to assist! And that he takes your functionality into account, not just echo results. Keep feeling better!!!