Body making too much Vitamin B6

Hello, I came across this post when researching hypophosphatasia, a rare genetic disease that causes soft bones and pain. B6 can be elevated along with alkaline phosphatase.

I just wanted to mention what I've found regarding high b6. My alkaline phosphatase (alp) levels have been consistently low. My b6 was in the 400 range at one point (although I was taking a b complex with 5 mg b6). I found that hypophosphatasia is a rare disorder which can result in low alp. For some reason, b6 is also elevated in individuals with hypophosphatasia. I would encourage those with high b6 to get their alp tested and research hypophosphatasia. It's often misdiagnosed as fibromyalgia in adults. Just wanted to share my findings in hopes it'll help someone.

Hello @ally78, welcome to Connect. If you are comfortable sharing, have you been diagnosed with hypophosphatasia? If so, how do you manage and cope with your diagnosis and elevated b6 levels?

I noticed your comments were from 2019. What did your doctor come up with after conferring with colleagues?

Mine is off the charts too legs numb hands tingly. They don't know why either for me.

Hi @mdamiani57, Welcome to Connect. Sorry to hear you are having numbness and tingling in your hands and legs. Have you been diagnosed with neuropathy?

Yes I thought it was diabetic but never been full type 2 A1C 5.8 blood sugar always above 100 so we controlled. Then got worse about a year ago upper legs started feeling weird then considered a bulging disc in lumbar but now with a high B6 a year ago had high B12 so then started thinking maybe a metabolic hormone thing. Went to a Neurologist he said probably diabetes but all I read is that it says with out of controlled blood sugars but mine are as low as I can get them so I'm at a loss.

I also fit the metabolic syndrome but have been working on getting healthier the past few years as I also think it plays a part in my neuropathy symptoms which are numbness and some tingling but no pain. Here are some references on the metabolic syndrome that you might find helpful for learning more.

-- Diagnosis and Management of the Metabolic Syndrome
https://www.ahajournals.org/doi/10.1161/circulationaha.105.169404
-- The metabolic syndrome – What is it and how should it be managed?
https://journals.sagepub.com/doi/full/10.1177/2047487319886404
-- A comprehensive definition for metabolic syndrome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675814/
-- The Metabolic Syndrome and Neuropathy: Therapeutic Challenges and Opportunities: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881591/
-- Metabolic syndrome as a risk factor for neurological disorders
https://pubmed.ncbi.nlm.nih.gov/21997383/

And the YouTube videos that got me thinking more seriously about my lifestyle choices...
--- Dr. Jay Wortman - 'Undoing Atkins: A Cautionary Tale'
https://www.youtube.com/watch?v=jIegMp5cWBY
--- Dr Jay Wortman Diabetes Remission is Surprisingly Simple!
https://www.youtube.com/watch?v=Cx6xw3wOAMc

Thank you for the info.

Your body does not make B vitamins you get it from food and supplements it is water soluble Do you have good kidney function ?