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Body making too much Vitamin B6

Posted by granolamama @granolamama, Feb 15, 2019

I had many labs done this week in an attempt to figure out why I am dealing with chronic muscle and joint pain, and severe exhaustion and weakness. The results came back showing that my B6 (normal range is 2-20) is 116. I do take one supplement each evening, and my doctor said it’s far less than she even takes, and in no way would account for such a number. She is completely confused, saying she has never seen such a thing, and couldn’t even come up with any info on it. She will spend some time meeting with other doctors this weekend to brain storm.
I’m wondering if anyone has experienced this, or has any info. I am googling like a mad woman, and the only info I can find is about people taking too much B6 in supplement form, and the dangers of it in their system. Nothing whatsoever about a person’s body making too much. Ideas?

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trooperdogg1960 | @trooperdogg1960 | May 10 7:49am
In reply to @melweckert "I have had very high serum Vit B6 too (250) for over 8 years at least..." + (show)
Profile picture for melweckert @melweckert

I have had very high serum Vit B6 too (250) for over 8 years at least but take absolutely no Vit B6 supplements in any form.

I have MECFS and thought that caused my peripheral neuropathy.

I have discovered a 2019 paper by Chelban et al (PDXK Mutations Cause Polyneuropathy Responsive to Pyridoxal 50-Phosphate Supplementation)

The paper suggests that some people have mutations that stop the conversion of vitamin B6 into its active form, pyridoxal 5'-phosphate (PLP).

Sometimes the situation can be rescued with PLP supplementation.

So, I may have loads of the WRONG SORT of Vit B6 floating around in my blood and still have a B6 deficiency (!!)

I'll check with my doctor first - but might try the PLP supplements.

The Google AI says: 'These supplements are used to treat specific conditions, such as certain types of seizures, where the body cannot convert other forms of vitamin B6 into the active form. Unlike typical vitamin B6 supplements (like pyridoxine), PLP supplements directly provide the active vitamin, which may be necessary for those with certain enzyme deficiencies. However, PLP supplements are used less frequently than pyridoxine and are primarily prescribed under medical supervision due to potential side effects like liver toxicity with long-term use.'

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@melweckert I had high b6. Doc told me stop taking my multi vitamin. That did it.

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