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Body making too much Vitamin B6

Posted by granolamama @granolamama, Feb 15, 2019

I had many labs done this week in an attempt to figure out why I am dealing with chronic muscle and joint pain, and severe exhaustion and weakness. The results came back showing that my B6 (normal range is 2-20) is 116. I do take one supplement each evening, and my doctor said it’s far less than she even takes, and in no way would account for such a number. She is completely confused, saying she has never seen such a thing, and couldn’t even come up with any info on it. She will spend some time meeting with other doctors this weekend to brain storm.
I’m wondering if anyone has experienced this, or has any info. I am googling like a mad woman, and the only info I can find is about people taking too much B6 in supplement form, and the dangers of it in their system. Nothing whatsoever about a person’s body making too much. Ideas?

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trooperdogg1960 | @trooperdogg1960 | May 10 7:49am
In reply to @melweckert "I have had very high serum Vit B6 too (250) for over 8 years at least..." + (show)
Profile picture for melweckert @melweckert

I have had very high serum Vit B6 too (250) for over 8 years at least but take absolutely no Vit B6 supplements in any form.

I have MECFS and thought that caused my peripheral neuropathy.

I have discovered a 2019 paper by Chelban et al (PDXK Mutations Cause Polyneuropathy Responsive to Pyridoxal 50-Phosphate Supplementation)

The paper suggests that some people have mutations that stop the conversion of vitamin B6 into its active form, pyridoxal 5'-phosphate (PLP).

Sometimes the situation can be rescued with PLP supplementation.

So, I may have loads of the WRONG SORT of Vit B6 floating around in my blood and still have a B6 deficiency (!!)

I'll check with my doctor first - but might try the PLP supplements.

The Google AI says: 'These supplements are used to treat specific conditions, such as certain types of seizures, where the body cannot convert other forms of vitamin B6 into the active form. Unlike typical vitamin B6 supplements (like pyridoxine), PLP supplements directly provide the active vitamin, which may be necessary for those with certain enzyme deficiencies. However, PLP supplements are used less frequently than pyridoxine and are primarily prescribed under medical supervision due to potential side effects like liver toxicity with long-term use.'

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@melweckert I had high b6. Doc told me stop taking my multi vitamin. That did it.

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muckdenise | @muckdenise | Jul 28 9:58am
In reply to @hotrod83 "@sueinmn I found this very helpful. A recent blood test indicated a B6 reading of 299.9,..." + (show)
Profile picture for hotrod83 @hotrod83

@sueinmn I found this very helpful. A recent blood test indicated a B6 reading of 299.9, naturally I am overwhelmed as I do not take any B vitamins. I was also diagnosed with sensory motor polyneuropathy which I was blaming on nerve damage from 2024 back surgery. Now I just don't know. Thanks for sharing the article.

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@hotrod83 have you been checked for hypophosphatasia? Mayo is one of the leading research facilities for Adult HPP

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muckdenise | @muckdenise | Jul 28 10:03am

Humans do not make B6. All the B6 comes through your diet or supplements. B6 is the only B vitamin that your body stores. If you are deficient in Alkaline phosphatase your body cannot balance it correctly . Stop taking all supplements. May be hypophosphatasia

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hotrod83 | @hotrod83 | Jul 29 11:07am
In reply to @muckdenise "@hotrod83 have you been checked for hypophosphatasia? Mayo is one of the leading research facilities for..." + (show)
Profile picture for muckdenise @muckdenise

@hotrod83 have you been checked for hypophosphatasia? Mayo is one of the leading research facilities for Adult HPP

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@muckdenise No I have not been checked for hypophosphatasia. Actually, I never heard of it, so I googled it. Thank you for the information. I plan to research it. Btw, I do not take any supplements containing B6.

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arbez | @arbez | Jul 29 12:44pm

I do have an idea. You may want to look into hypophosphotasia. It is a genetic disease and not well known by doctors. Also causes pain, fractures, dental issues, etc. There is a Facebook group.

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cardigan | @cardigan | Jul 29 4:26pm

I have heard about a condition called Haemochromatosis.It is iron overload.It can cause a lot of problems in the body and has to be monitored.

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muckdenise | @muckdenise | Jul 31 9:24am
In reply to @hotrod83 "@muckdenise No I have not been checked for hypophosphatasia. Actually, I never heard of it, so..." + (show)
Profile picture for hotrod83 @hotrod83

@muckdenise No I have not been checked for hypophosphatasia. Actually, I never heard of it, so I googled it. Thank you for the information. I plan to research it. Btw, I do not take any supplements containing B6.

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@hotrod83 HPP doesn't have anything to do with supplements. When I was tested I had one of the highest levels (272) the Doctor had seen, My body is slow at removing B6 and transfer into the brain and cells. Definitive test is low ALP and High B6.

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