Beginning the Zepbound journey

Posted by mef46 @mef46, Nov 11, 2025

I’m a 78 year old retired teacher who has struggled with being overweight since my late 30’s. I’ve tried numerous diets over the years but none were successful for very long. Now I’m dealing with a multitude of health conditions….high blood pressure, fibromyalgia, GERD, sleep apnea, glaucoma, asthma, multiple allergies, arthritis… to name a few. My 80’s are looming in the near future. I just received clearance to begin Zepbound. Does anyone have any experience with this GLP—1 that could share any tips, advice or approach to meal planning while on this weight loss medication?…I’m hoping that losing weight will help me reduce medications and overcome some of the many chronic conditions which have impacted my quality of life. —Mary from Indiana

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Profile picture for krein89 @krein89

@psblin99 I hope your side effects ease up as your body adjusts to 5mg, but definitely would stay at 5mg for a few months before increasing. I’ve been on 7.5mg for 3 months and still losing weight so I don’t plan to increase. Talk with your clinician about ways to ease side effects. What you eat and drink makes a big difference in how you feel on these meds.

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@krein89 Thanks

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Profile picture for psblin99 @psblin99

@krein89 Good advice. I did 2.5 for 4 weeks and now one shot of 5. Not enjoying the 5. Nauseous, constipated, on and off headache, and actually hard to eat anything.. I am going back to 2.5. I have 3 weeks left of 5 but I am only going to inject 1/2 dose.

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@psblin99 I hope your side effects ease up as your body adjusts to 5mg, but definitely would stay at 5mg for a few months before increasing. I’ve been on 7.5mg for 3 months and still losing weight so I don’t plan to increase. Talk with your clinician about ways to ease side effects. What you eat and drink makes a big difference in how you feel on these meds.

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Profile picture for krein89 @krein89

@barb73 I think your doctor is increasing your dose too fast. I noticed an increase in side effects when I went from 5 mg to 7.5 mg so asked my doctor if I could just stay at 7.5 mg for a few months since I was losing weight and tolerating the side effects at that dose. Why risk having worse side effects if I’m making progress on the current dose. That’s working well for me and I plan to stay at 7.5 for as long as it’s working. You don’t have to keep increasing the dose—talk with your clinician about staying at a lower dose for a longer period of time.

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@krein89 Good advice. I did 2.5 for 4 weeks and now one shot of 5. Not enjoying the 5. Nauseous, constipated, on and off headache, and actually hard to eat anything.. I am going back to 2.5. I have 3 weeks left of 5 but I am only going to inject 1/2 dose.

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Profile picture for barb73 @barb73

I’m 73, started on 2.5 mg dosage, now up to 10 mg. All of a sudden I’m have stomach discomfort, drinking one cup of coffee makes my stomach hurt. Also belching constantly. My doctor wants me to increase to 12.5 and then to 15 mg which I will stay on.

I haven’t had many problems up to this point (other than constipation). Not sure what’s going on. Tried Tums, they do not help. Now trying GasX.

Thanks.

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@barb73 I think your doctor is increasing your dose too fast. I noticed an increase in side effects when I went from 5 mg to 7.5 mg so asked my doctor if I could just stay at 7.5 mg for a few months since I was losing weight and tolerating the side effects at that dose. Why risk having worse side effects if I’m making progress on the current dose. That’s working well for me and I plan to stay at 7.5 for as long as it’s working. You don’t have to keep increasing the dose—talk with your clinician about staying at a lower dose for a longer period of time.

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Profile picture for bhb30602 @bhb30602

Has anyone experienced rapid heart rate after being on Zepbound for a while? My BP is normal range but heart rate is more rapid than usual. It's happened 2-3 times over the past 7 days. I have breakfast, but have only been having a protein shake or liquid meal replacement. Not much for dinner bc I'm not hungry.
I'm going to make myself eat something (solid) for lunch and dinner today and see if that helps.
Any similar experiences?
Thanks in advance for any comments.

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@bhb30602 I wonder if you’re on too high of a dose? You shouldn’t have total loss of appetite and I don’t think rapid heart rate is typical. You should contact your clinician about this.

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Has anyone experienced rapid heart rate after being on Zepbound for a while? My BP is normal range but heart rate is more rapid than usual. It's happened 2-3 times over the past 7 days. I have breakfast, but have only been having a protein shake or liquid meal replacement. Not much for dinner bc I'm not hungry.
I'm going to make myself eat something (solid) for lunch and dinner today and see if that helps.
Any similar experiences?
Thanks in advance for any comments.

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Profile picture for mcgeehin @mcgeehin

Has anyone plateaued at about 5 lbs short of their goal. I don’t want to go up to a higher dose. Any ideas?

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@mcgeehin good news that you’re so close to your goal!
A few ideas:
try upping your calories for a few days. Sometimes a change will trigger your body into going out of the mode it is in.
Meticulously track your calories to ensure you’re on the deficit you want to be on. At least until you are confident on it.
Be patient. Sometimes losing strategy last bit won’t come for a while. Give it time.
Accept that maybe this is where you should be. It could be perfect weight for you.
Recalculate your calorie needs based on your new weight. It may be different now that you weigh less.
Make sure you’re drinking enough water and eating protein
Go to a higher dose even though that may not be your desire right now. Switch back down when you meet your goal.
Good luck to you on your journey!

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Profile picture for cabby @cabby

Start at the lowest dose and work your way up to the dosage your body can tolerate. Be ready to be extremely tired, have a headache that comes and goes, and be sure to receive medication for nausea. That being said, my primary symptom is skin sensitivity. At times, the bedsheet bothers me so much when touching my legs. It's a weird feeling. That being said, many days I have no desire for food whatsoever, and that has made my weight loss journey easier than ever. Eat lots of protein. And eat some more protein. Good luck!

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@cabby it is a very strange feeling. Today all my clothing drove me crazy! I couldn’t wait to get home and shower and put my robe on. But even my robe bothered me. I did find that applying lotion on my skin took the fire away. Maybe give it a try?

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Has anyone plateaued at about 5 lbs short of their goal. I don’t want to go up to a higher dose. Any ideas?

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Profile picture for Lisa Lucier, Moderator @lisalucier

@maysh47 - wondering where you are at today with your weight loss? You mentioned you felt the limiting your calories to 800 per day was a mistake. Did you decide to continue on the tirzepatide (Zepbound), or did you go another route entirely for weight loss?

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@lisalucier After a bout with dizziness & other probs r/t nutrition I stopped zep, gained to 180 lbs felt much better & started the Fondeyo, the oral pill. It doesn’t work for me and now I weigh 197 lbs and because I don’t qualify for the Bridge program thru Medicare must pay full price for the zep. So I’m stalled with all the craving & food noise I started with.

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