Anyone stopped taking Repatha after trying?

Posted by bethrva @bethrva, Jun 4, 2025

I experienced stiffness and upper back pain the morning after injecting first dose of Repatha. Began taking Bayer, then Advil, when PCP suggested ibuprofen. On day two, the back pain continued to my shoulder socket and pain increased from about a 3 to about a 6. Today is day four and I am at 6x the recommended dosage of Advil to try and manage the pain. Sent note to PCP this morning that I'm leery about taking a 2nd dose of Repatha and would like to come off of it. Did everyone else soldier on through the 2nd dose? Or tempted to quit but didn't? I injured my back about 12 years ago. It healed with no problems. But the Repatha seems to be hammering at the spot of that old injury. I feel certain it's the Repatha, because nothing else has changed (i.e., not taking any other Rx's, haven't re-injured myself, and was feeling tip-top before the injection). Yoga and ibuprofen aren't having any effect. Sleep has been difficult the last two nights. I can cope okay with the stomach churning and chills; it's the increasing pain and sleeplessness that are wearing me down. If you did quit, can you say roughly how long the Repatha stayed in your system until you felt better? This is the 140 mg/mL dose that you inject twice monthly. On it for high cholesterol of 375 mg/dL.

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I was on Reparha for 4 months. I started feeling crappy after two weeks. Stomach and severy pain in my bowels. Then I got mussle pains. Tolerable ar firt, bus gradualy incapacitating. I stopped when the spasms in my leg started. They lasted for hours.

Now I'm going to try again with inclisiran.

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