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Anyone participating in the Tapestry DNA Sequencing Research?

Posted by dazlin @dazlin, Oct 19, 2020

if you have volunteered or declined to participate, I'd like to here your thoughts. I was on the fence, very undecided, yet I decided to go ahead to do it. I have a few low grade health problems im dealing with , and really dont want to hear anymore. That said, I realize this testing may be of great value at some point. Also its strictly voluntary and can be declined at anytime. I sent mine in today.
Whats your thoughts??

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zebragal | @zebragal | Dec 28, 2023

Hello, yes I did my sample today and it will be going out in tomorrow's mail

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1 reply
gratefulbob | @gratefulbob | Jan 6 3:07pm

The Tapestry Study is primarily focused on hereditary cancers and heart disease I believe. I personally was not impressed with the results I received back from Helix (the company that does the actual sequencing). I have had my genome also sequenced by another company and got far more comprehensive and in-depth results which explained several unexplained health issues I had. They found I had a mutation which affected tacrolimus metabolism which explained the convulsions I had when taking it post surgery. The other company also found I have a mutation in folate metabolism which is easily treated by taking methylated B vitamins. I never would have known this if I had not had my entire genome sequenced by that company. It costs me $500 but was worth it in my opinion.

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1 reply
raye | @raye | Jan 7 11:34am
In reply to @gratefulbob "The Tapestry Study is primarily focused on hereditary cancers and heart disease I believe. I personally..." + (show)
@gratefulbob

The Tapestry Study is primarily focused on hereditary cancers and heart disease I believe. I personally was not impressed with the results I received back from Helix (the company that does the actual sequencing). I have had my genome also sequenced by another company and got far more comprehensive and in-depth results which explained several unexplained health issues I had. They found I had a mutation which affected tacrolimus metabolism which explained the convulsions I had when taking it post surgery. The other company also found I have a mutation in folate metabolism which is easily treated by taking methylated B vitamins. I never would have known this if I had not had my entire genome sequenced by that company. It costs me $500 but was worth it in my opinion.

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It would be helpful to know the names and prices of the companies you liked, please.
BTW, I didn’t find the Tapestry Helix study very helpful either.

Regarding the folate metabolism, I have MTHFR homozygous for C677T. Regular folic acid did not help. What brought my folate to normal level was Nature’s Truth brand L-methylfolate. Please notice that “L”in the name before the methylfolate. It is important. I found this at the largest Rite-Aid store in my neighborhood. Taking only three capsules weekly after breakfast is adequate for me. Hope this helps!

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1 reply
Moderator
Colleen Young, Connect Director | @colleenyoung | Jan 7 3:28pm
In reply to @zebragal "Hello, yes I did my sample today and it will be going out in tomorrow's mail" + (show)
@zebragal

Hello, yes I did my sample today and it will be going out in tomorrow's mail

Jump to this post

Hi @zebragal, can I help connect you with other members or topics of interest?

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gratefulbob | @gratefulbob | Jan 7 4:28pm
In reply to @raye "It would be helpful to know the names and prices of the companies you liked, please...." + (show)
@raye

It would be helpful to know the names and prices of the companies you liked, please.
BTW, I didn’t find the Tapestry Helix study very helpful either.

Regarding the folate metabolism, I have MTHFR homozygous for C677T. Regular folic acid did not help. What brought my folate to normal level was Nature’s Truth brand L-methylfolate. Please notice that “L”in the name before the methylfolate. It is important. I found this at the largest Rite-Aid store in my neighborhood. Taking only three capsules weekly after breakfast is adequate for me. Hope this helps!

Jump to this post

I used sequencing.com and was pleasantly surprised by how in depth the results are.
Note they attempt to make money by their data analysis subscription and offering the initial sequencing service and data analysis fairly inexpensive. IMHO, the initial data analysis is sufficient but you should download the FastQ, BAM and VCF files for your own records and future analysis. One feature that I like is that you can upload other data from Ancestry, Heritage etc. to compare the results. Helix has never given me my own raw data despite numerous requests. This is a violation of HIPAA regulations and has really made me suspect of their data analysis.

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