Anyone on Pluvicto (Lu 177), a new drug for prostate cancer?

Posted by dedehans @dedehans, Aug 20, 2022

My close friend has had Pluvecto treatment suggested to him by oncologists. It is relatively new, having been approved by the FDA in March 2022. Have any of you been given this drug? I have read it is radioactive material and patient needs to stay away 6 ft from others for at least 3 days so as not to contaminate them. He has not yet decided whether to take the treatment or not as he is feeling awful enough as is.

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dwpoole | @dwpoole | Jun 24, 2023

In reply to @dwpoole "https://www.mskcc.org/cancer-care/clinical-trials/22-134. I’ll try to send some more" + (show)

https://www.clinicaltrials.gov/study/NCT04443062?tab=history&a=1

dwpoole | @dwpoole | Jun 24, 2023

In reply to @pauljay "I can't find the journal article using Google. Do you have the url?" + (show)

https://www.mskcc.org/cancer-care/clinical-trials/22-134.

I’ll try to send some more

pauljay | @pauljay | Jun 24, 2023

In reply to @dwpoole "Yes stage 3." + (show)

Good.

dwpoole | @dwpoole | Jun 24, 2023

In reply to @pauljay "My fatigue during the daytime isn't bad, probably because I exercise a lot. It's gotten a..." + (show)

Yes stage 3.

pauljay | @pauljay | Jun 24, 2023

In reply to @dwpoole "There’s a 2022 description of the trial in journal of clinical oncology but I could figure..." + (show)

I can't find the journal article using Google. Do you have the url?

pauljay | @pauljay | Jun 24, 2023

In reply to @dwpoole "The only symptom I can clearly blame on pluvicto is dry mouth which is pretty bad...." + (show)

My fatigue during the daytime isn't bad, probably because I exercise a lot. It's gotten a bit worse in the evening during the last few months, though. I go to bed soon after dinner.
Was your trial stage III?

dwpoole | @dwpoole | Jun 24, 2023

In reply to @dwpoole "There’s a 2022 description of the trial in journal of clinical oncology but I could figure..." + (show)

The only symptom I can clearly blame on pluvicto is dry mouth which is pretty bad. I have a lot of fatigue but I’m guessing it’s from the ADT.
Has you fatigue gotten better than in the first six months of ADT. I’m hoping mine gets better with time.

dwpoole | @dwpoole | Jun 24, 2023

In reply to @pauljay "I have uncountable mets in my spine, ribs, sternum and pelvis. I started Lupron and Zytiga..." + (show)

There’s a 2022 description of the trial in journal of clinical oncology but I could figure out how to attach it. Google Lu 177 trial for castate sensible pc.

dwpoole | @dwpoole | Jun 24, 2023

In reply to @pauljay "I have uncountable mets in my spine, ribs, sternum and pelvis. I started Lupron and Zytiga..." + (show)

They / Novartis just closed it at MD Anderson and probably everywhere. My guess is they have enough data to go for FDA approval. I expect it to be approved soon.

pauljay | @pauljay | Jun 24, 2023

In reply to @dwpoole "I will receive my 5th treatment today. I am also on Lupron and zytiga and still..." + (show)

I have uncountable mets in my spine, ribs, sternum and pelvis. I started Lupron and Zytiga in December 2021 and I'm still castration sensitive. My PSA is undetectable and I feel pretty good, but I worry about the future. Is your clinical trial still open? Can I look it up to see the criteria for joining? How do you feel?