Anyone on Pluvicto (Lu 177), a new drug for prostate cancer?

Posted by dedehans @dedehans, Aug 20, 2022

My close friend has had Pluvecto treatment suggested to him by oncologists. It is relatively new, having been approved by the FDA in March 2022. Have any of you been given this drug? I have read it is radioactive material and patient needs to stay away 6 ft from others for at least 3 days so as not to contaminate them. He has not yet decided whether to take the treatment or not as he is feeling awful enough as is.

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@digger

I might be going on pluvicto depending on my test results I would like to hear from people who have been on it and how it worked in the side effects. Thanks. Dave

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Hello @digger. You will notice I have moved your post on Pluvecto into an existing discussion that you can now find here:
- Anyone on Pluvicto (Lu 177), a new drug for prostate cancer?: https://connect.mayoclinic.org/discussion/any-one-on-pluvecto-a-relatively-new-drug/

I did this to allow you to connect with members like @hbp @melcanada @stonewalker and @dwpoole.

Have you heard back on your test results?

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I have scans on July 5 which I hope show improvement.

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@suwairi

What does it mean that my PSA continues to rise despite taking two doses of Pluvicto?

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My PSA also rose after two treatments. My oncologist and I decided the Pluvicto was not working and cancelled further treatments. Two weeks later my PSA plummeted from 37.6 to 7.2 and then three days later to 5.4

We're back on the Pluvicto treatment schedule.

I will say that the second dose caused me much major discomfort in my GI tract. My bowels and bladder were hard to empty for days. Managed to get past it, but I did think I was finished at that point. Depression, as we all know, is too real now.

My best wishes and prayers to all my comrades out there and their caretakers.

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@amandajro

Hello @digger. You will notice I have moved your post on Pluvecto into an existing discussion that you can now find here:
- Anyone on Pluvicto (Lu 177), a new drug for prostate cancer?: https://connect.mayoclinic.org/discussion/any-one-on-pluvecto-a-relatively-new-drug/

I did this to allow you to connect with members like @hbp @melcanada @stonewalker and @dwpoole.

Have you heard back on your test results?

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Yes more cancer none in lymp notes ,I am able to get LU 177 I go back on chemo 7/12 I hope to only have at the most 4 cycles of chemo then on L u 177 I’m hoping currently on oxycode. For pain not looking forward to all the chemo side effects loss of taste buds don’t want to eat neuropathy in my feet but it’s better than the alternative find out more on the 12th and we go back to see the doctors to get the chemo. Thanks for asking.

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@amandajro

Hello @digger. You will notice I have moved your post on Pluvecto into an existing discussion that you can now find here:
- Anyone on Pluvicto (Lu 177), a new drug for prostate cancer?: https://connect.mayoclinic.org/discussion/any-one-on-pluvecto-a-relatively-new-drug/

I did this to allow you to connect with members like @hbp @melcanada @stonewalker and @dwpoole.

Have you heard back on your test results?

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Amanda How do I link back into Stage 4 PC tracks

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@stonewalker

My PSA also rose after two treatments. My oncologist and I decided the Pluvicto was not working and cancelled further treatments. Two weeks later my PSA plummeted from 37.6 to 7.2 and then three days later to 5.4

We're back on the Pluvicto treatment schedule.

I will say that the second dose caused me much major discomfort in my GI tract. My bowels and bladder were hard to empty for days. Managed to get past it, but I did think I was finished at that point. Depression, as we all know, is too real now.

My best wishes and prayers to all my comrades out there and their caretakers.

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For anyone plugged up... check with your doctor or pharmacist and try taking Magnesium Glycinate a couple times a day and night and it will bring fluid into your digestive tract and help you eliminate.
Also, check out herbdoc.com Intestinal formula 1 which will help your digestive muscles contract and push the goodies out.

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@suwairi

What does it mean that my PSA continues to rise despite taking two doses of Pluvicto?

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Could be Tumor Flare. Seems MCRPC doesn't like being attacked. I will report my Pluvicto process.

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Can anyone give feedback on how Pluvicto treatment response is being determined? is it MRI, CT, a PSMA PET scan with F-18 or G-68 agent? If with PSMA PET, has insurance been covering it? Cost is a concern. thanks

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