Antidepressant withdrawal while taking them?

Posted by morganjane @morganjane, Dec 9, 2023

I’m not very confident anyone else has experienced this, but it doesn’t hurt to ask. I’ve been dealing with a really weird “thing” for about 3 years now. No doctors seem to know what’s causing it & I can’t find anything about it online. Little backstory, I was on Paxil for about a decade for depression & panic attacks. Worked great. Then, 3 years ago I woke up one day & started having the dreaded brain zaps & my emotions were all over the place, I was having panic attacks again, crying, depressed, flat, crying again, etc. I was withdrawing but I hadn’t changed my meds in any way, took them like clockwork every day. Doctor changed my meds to Prozac. Same exact thing, withdrawal symptoms while taking the meds religiously at the same time daily. Fast forward to today, I’ve been on every antidepressant known to mankind, every dose, same exact outcome.
It just doesn’t make sense. Am I metabolizing them too fast or not absorbing them or…..? I’ve tried to taper off of them completely so I can go another route but it’s been absolutely impossible each time. It’s the same withdrawal symptoms but times 1000.

We don’t have good resources here in Arkansas but my insurance doesn’t really do much out of state, so I have no choice but to continue researching it on my own. Mayo Clinic would be a dream to get into but realistically, this is the closest I’m going to get. Anyone experience these issues too? Any good resources or recommendations or suggestions?

I’ve also done the GeneSight test as well. Tried the meds on the list, no change.

Interested in more discussions like this? Go to the Depression & Anxiety Support Group.

Profile picture for John1984 @jschwing

MorganJane:

Just read this and I have had a similar situation with Paxil. Was utilizing 12.5 CR for 17 years successfully. Then, following a surgery I had intense panic and anxiety. It was almost like I went off of the Paxil all at once. That has been a year ago, and I have tried other medications through a psychiatrist, but nothing seems to lift this depression and anxiety. The first try was to up the Paxil CR dose and that failed. It almost seems like we get one shot with SSRI medications. It is almost like the first medication makes you treatment resistant in the future. I am weaning off the Paxil now which is causing increased depression. The anxiety is sort of constant especially in the mornings. Since weaning, my Doctor has me trying one more SSRI, Celexa , to try to break this cycle and lower the depression. And before everyone piles on, I have tried all the alternative methods; TMS, brain retraining, acupuncture, detox, neurofeedback, mindfulness.

Did not get brain zaps; maybe the Paxil was not really working anymore. I have found through research that Paxil use inhibits one of the key metabolizing enzymes used in a lot of phych meds. This is the reason I am trying Celexa because it uses a different primary enzyme. Also did the Gene site test.

Hope you have found some relief.

Just praying that I get some relief from The Celexa. Zoloft and Pristiq did not yield results.

Jump to this post

I have not had any good results with antidepressants in many years, only once when I was given Paxil for anxiety and it helped a lot, I felt like a new person rather quickly but after six months I couldn’t cope with them anymore, they just stopped working and I felt worse. I tried numerous brands that had no effect and other brands that caused bad side effects. They found a brand that I use regularly at a very low dose and it helps a little, many people have difficulty with antidepressants.

REPLY

Hi there i have just come across your post about this issue, I like you am going through the same thing. Been on paxil 21 years now. And 3 years ago I woke up and started with experience withdrawals, brain zaps, tiredness, balance issues ect ect. I was wondering did you ever find a cure to solve this? I am going through this 3 years now and to be honest, I'm just mentally drained from it.

REPLY

I have gone through this with Paxil and am in the process of slowly slowly tapering and adding Prozac. Im doing this with my psychiatrist following me. Paxil has difficult withdrawal symptoms when trying to taper. My change will require a long time if Prozac works. I was on Paxil, like you for many years. It is no longer effective.

REPLY
Profile picture for frouke @frouke

I have not had any good results with antidepressants in many years, only once when I was given Paxil for anxiety and it helped a lot, I felt like a new person rather quickly but after six months I couldn’t cope with them anymore, they just stopped working and I felt worse. I tried numerous brands that had no effect and other brands that caused bad side effects. They found a brand that I use regularly at a very low dose and it helps a little, many people have difficulty with antidepressants.

Jump to this post

Which brand is working for you now?

REPLY
Profile picture for kaliope @kaliope

Which brand is working for you now?

Jump to this post

I’m taking Amitriptyline 20 mg. daily, it’s an older antidepressant, it helps a little but if I increase my dose I get symptoms. It’s really frustrating to have this problem because I need something to help me with anxiety and depression, I also take Ativan to help with anxiety.

REPLY
Profile picture for frouke @frouke

I’m taking Amitriptyline 20 mg. daily, it’s an older antidepressant, it helps a little but if I increase my dose I get symptoms. It’s really frustrating to have this problem because I need something to help me with anxiety and depression, I also take Ativan to help with anxiety.

Jump to this post

I wanted to add that your problem with antidepressants is more common than than most people realize, I did some research a while back and read that they are working with LSD for help, of course it’s been changed from the stuff people used to get high, another thing was certain mushrooms were also in use now for people who can’t get help from the medications currently available. My oldest son who has suffered from anxiety for years but he never used medication for it started taking mushrooms in prescribed doses and he is very happy with the results, I’m not sure if I have the nerve to try it but if I did, it would have to be done with the help from a homeopath or a doctor who is experienced with this medicine.

REPLY
Profile picture for frouke @frouke

I’m taking Amitriptyline 20 mg. daily, it’s an older antidepressant, it helps a little but if I increase my dose I get symptoms. It’s really frustrating to have this problem because I need something to help me with anxiety and depression, I also take Ativan to help with anxiety.

Jump to this post

It’s all so scary - i used Lexapro twice 10 years ago, and then again 5 years ago, and it worked perfectly. I needed it again, even doubled the dose, but barely working now. I tried Zoloft and it drove me crazy , my body was shaking constantly. I also take Ativan, .5 mg. But not working as well as it used to either. I’m afraid to keep trying new meds.

REPLY
Profile picture for kaliope @kaliope

It’s all so scary - i used Lexapro twice 10 years ago, and then again 5 years ago, and it worked perfectly. I needed it again, even doubled the dose, but barely working now. I tried Zoloft and it drove me crazy , my body was shaking constantly. I also take Ativan, .5 mg. But not working as well as it used to either. I’m afraid to keep trying new meds.

Jump to this post

I’m sorry that you’re having such a rough time with this, it’s not uncommon to go through difficulties finding a medication but in your experience and also mine, we have limited access to resources so we pretty much have to do our own research, I’m still not in a good place and it worries me especially when my physical health is not good, I’m struggling to keep weight on because my mental health robs me of things like appetite and sleep and this just adds to the stress. I sincerely hope that you will find help for yourself, try not to get discouraged and keep reaching for new ideas, it’s about all we have so we have to keep trying, also if you can find a homeopath in your area, they have different options for you and it’s often very helpful.

REPLY
Profile picture for frouke @frouke

I’m sorry that you’re having such a rough time with this, it’s not uncommon to go through difficulties finding a medication but in your experience and also mine, we have limited access to resources so we pretty much have to do our own research, I’m still not in a good place and it worries me especially when my physical health is not good, I’m struggling to keep weight on because my mental health robs me of things like appetite and sleep and this just adds to the stress. I sincerely hope that you will find help for yourself, try not to get discouraged and keep reaching for new ideas, it’s about all we have so we have to keep trying, also if you can find a homeopath in your area, they have different options for you and it’s often very helpful.

Jump to this post

Thank you for your reply and your concern. Good luck and may you find the answer which will alleviate these issues.

REPLY
Please sign in or register to post a reply.