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Anyone experience mood swings and nervousness with Anastrozole?

Posted by jc1926 @jc1926, Aug 11, 2022

I have been taking anastrozole for only 5 months now. I had a lumpectomy and 20 radiation treatments. Just recently I have been experiencing nervousness and mood swings. Has anyone else had any of these side effects?

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hoping74 | @hoping74 | May 11 6:43pm
In reply to @shoefly "@bloncape God bless you for your wonderful and kind words. Yes, I had five very good..." + (show)
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@bloncape
God bless you for your wonderful and kind words. Yes, I had five very good years and I don’t feel defeated now. No matter the future, I find something to enjoy in each day God gives me.

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@shoefly
There is so much strength to be found in these posts. I started anastrozole in Dec '25 and stopped 11 wks later due to frequency, variety and intensity of side effects. Started exemestane and 5 wks in I am worse. Joint pain, carpal tunnel, and so on. Anastrozole also left me with early osteoporosis. Trust yourself. Ask questions, spend as much time as you need to assess info you receive, and remember no one knows your body as well as you do. AIs are a mystery to me. I know I am ready to stop and will live my life every day the way I always have, before BC came along: grateful to God for the gift of life he has blessed me with and every new day he sends to me.

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lifetraveler | @lifetraveler | May 12 6:21am
In reply to @shoefly "Absolutely have been experiencing anxiety and mood swings. I had lobular breast cancer, lumpectomy, and 33..." + (show)
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Absolutely have been experiencing anxiety and mood swings. I had lobular breast cancer, lumpectomy, and 33 radiation treatments. I was supposed to start on an AI but after a couple of try’s with two different ones, I stopped taking anything. Five years later I now have metastatic bone cancer and am taking Anastrozole and will be starting Ibrance this week. I should have endured the AI’s after all. I pray you do well and God bless you.. .

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Dear @shoefly :

I am so sorry for what you've been suffering through! My heart simply ached and prayers went out for you upon reading your post...

Thank you so much for sharing your experience to help us all! I truly admire your wisdom with courage and caring love that face the challenges of life in stride.

Wishing you all a better journey ahead with hope, love, and peace from above!

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newtosc | @newtosc | May 12 7:12am

HI- I tried 20mg of Tamox and it made me crazy - I was so anxious and everything upset me I felt crazy. I dropped to 10mg and did not feel much better. I got off it for 30 days and now only take 2.5 a day. MD said I'd still see benefit of estrogen reduction but my goal is to be off in July or after 1 year. Looking at alternatives. I cannot live with the upset the CA produced and the drugs. These are powerful drugs and after reading comments, am not sure they work but.......gotta try.

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jwmusic65 | @jwmusic65 | May 16 2:50pm

Yes! I am suffering as you are and wondering if there is anything I can take to balance out the low mood issues.

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gailmarienewton | @gailmarienewton | May 17 7:04am

I am almost ready to start it...I finish my 33+5 radiation treatments in June . ( I had 3 tumors in right breast, (8.9 cm, 6 cm, 6 cm), and three in in left breast (2.2 cm, 2 mm, 6 mm). Radiation never even detected the left breast tumors. My breasts just kept shrinking. They were invasive lobular carcinoma. Thanks for the info. I am on so much medicine, it is worrisome. What do you mean by mood swings?

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