Amitriptylene + Hydrocodone - Safe?

I have used this combination when absolutely necessary. They are both depressants though so monitor her responses.. I did not have problems but dosage and circumstances come into play.

I was prescribed Ami. as well as Oxycodone,. I'm having no problems
I take the oxy all day and then 2 of
the Ani 30 to 60 minutes before bed, helps me a lot

GOOD LUCK !

I’ve taken hydrocodone for years off and on for chronic pain. I’ve also been on amitriptyline for many more years than the hydrocodone. I have not had problems, but that doesn’t mean they’re without their side effects. Also, everyone is different in the way they process their drugs so it could be very difficult for her. I always in the past have tried to space out them at least two hours apart so that I’m not taking them at the same time. Is the benefit of taking these drugs outweigh the cost for her?

This combination requires close supervision by a doctor. Here is some technical information for you.
https://www.drugs.com/drug-interactions/amitriptyline-with-hydrocodone-168-0-2874-0.html

Thanks to all for your inputs. I am amazed to hear that some of you can take both without much adverse effect. My wife is definitely off the Ami but tolerates the hydrocodone well although it has only a questionable effect - meaning that it barely dulls the pain to a point where she can sleep. I would think that if we ladder up the scale of narcotics, the next one to try would be the oxycodone (more potent than the hydrocodone?) and beyond that a fentanyl patch. The docs in this corner of Canada won't go all out with the most potent narcotics which I think has everything to do with all the fentanyl BS that Canada was subject to from the White House. It's a shame that thanks to politics, we are being denied the narcotics that are required to relieve our symptoms.

@jcaesar have you tried the combo of low-dose Oxycodone, plus Tylenol ? Oncologists use that for some patients.

The Tylenol, being OTC, I can get, but there's no way our doc would Rx the Oxycodone for us (low dose or otherwise), there's that much attention and negativity surrounding Oxy and Fentanyl in Canada. She is currently only on Hydrocodone, the short acting version, and it leaves a lot to be desired. Taking one before bedtime only allows her 4 hours of sleep before the pain wakes her. You ask why doesn't she take another at that point? She's afraid of the tolerance factor so she'd like to leave it at one/day. At least it doesn't have the zombie all day feeling that Amitriptyline caused.

@nycmusic one thing to know about oxycodone is that it can upset the stomach in some people…approach with care if you have sensitive stomach.

News Flash! I am mortified to have to tell you that I misread her Rx label. For some reason, I thought it was Hydrocodone but no! It was Hydromorphone!
So after dissing our family physician and the Canadian system in general, for not allowing the most potent drugs to be used when they’re needed, I find that in fact,
she has been given the the “nuclear option”, for which I am very grateful. Nothing like having to eat humble pie after mouthing off so much! Having said all that, I have the following to report. She has only been on the
hydromorphone for a week and because of her reluctance to be on it “round the clock”, she only takes it before bedtime, in other words, once a day. This is far from the allowable 6X / day so there’s a lot more potential for relief that is going unused. Still, with the HM, she gets 4 hours of sleep which is WAY better than the 0 hours that was the case previously. Also,there seems to be some sort of lingering effect from the single dose, as she reports that the pain, during the day, is less than previously. So the HM does seem to serve as the drug of choice (finally!). Best of all, unlike the Ami, there doesn’t seem to be the negative mental side effects, so for the time being, we seem to have arrived at a point where we have decent pain control and if things get to be a bit too much, she can always pop one
more.