Advantages of Eliquis or Xarelto over Coumadin?

I have had 2 episodes with PE. Now I am on Xarelto for life. Don't like that. I have muscle pain, joint pain, and tiredness. I could go on coumadin but am afraid of that too. I was on it about 10 years ago with no affects. Don't know what to do. I'm 64 and want to live normal.

I am always in the donut hole, got tired of it too. Look into healthwarehouse pharmacy.com and info@medicationscanada.com. It's a saving grace!

What is your insurance, if I may ask.....Most people pay hundreds of dollars for a 30 day supply.

Thank you for alerting me to this. I read through a LOT of information online about them. I am going to call the governor's office tomorrow to see if they can provide any additional information.

Sorry, I don’t feel the need to post documentation. You can search on Google and reach your own conclusion. Good luck.

I checked with the Canadian Pharmacy and their price was still outrageous. I checked with the company and they were $89.00 per month IF you qualified for their discount program. Believe me when I say I have checked every source. I am filing an appeal with Humana Gold but I really haven't much hope that they will approve it. Good luck to you as well.

Please send documentation of your claim that led you to this conclusion. Thank you.

I remain skeptical that antidotes are readily available to prevent bleeding when injuries occur to patients taking anticoagulants other than Coumadin (Warfarin). The positive Andexxa quote is four years old, and this antidote was submitted to further study and FDA review after that. I understand Praxbind was similarly placed under review after its original approval. Coumadin has a readily available and long-term antidote, but on three occasions it was not in stock at a clinic or urgent care facility when I came under treatment there. My advice to all is: Upon meeting a medical professional in a clinic, urgent care facility, or emergency room for treatment of a bleed, immediately ask them to assure you that they have the right antidote on hand for your variety of anticoagulant. A friend of mine on Coumadin died from a brain bleed when the hospital did not have the Vitamin K antidote in stock and they chose to air-transport him to a hospital 30 miles away too late.

A friend takes Eliquis without any apparent side effects, after having had leg weakness while on Xarelto. The major concern with these drugs initially was that there were not readily available antidotes, while bleeding while on Coumarin could be stopped with vitamin K. But there are antidotes now, so that seems to make doctors more comfortable prescribing them and sparing the patients the frequent blood work, which became a bigger issue during lockdown and when people were reluctant to go to medical facilities unless really necessary. Here's a blurb from the Harvard Health newsletter.

"The wait is over for an antidote to stop rare uncontrolled bleeding linked to some newer blood thinners. The FDA approved andexanet alfa (AndexXa) on May 3, 2018. It's the first and only antidote to reverse bleeding in people taking apixaban (Eliquis), rivaroxaban (Xarelto), or edoxaban (Savaysa).

Another newer blood thinner — dabigatran (Pradaxa) — already has an approved antidote called idarucizumab (Praxbind). A dose of vitamin K is used to reverse the action of warfarin (Coumadin), a blood thinner used routinely for more than half a century and, until recently, the only such option for most people."
https://www.health.harvard.edu/diseases-and-conditions/more-antidotes-for-newer-blood-thinners

@tct, you're wise to do your research on the specific pharmacy you use when it comes to ordering online. I offer these articles to help you vet reliable online services.

— Choosing a safe online pharmacy: https://www.canada.ca/en/health-canada/topics/buying-using-drug-health-products-safely/safe-use-online-pharmacies.html
— So-Called “Canadian” Pharmacies are a Danger to Consumers, NABP Reports: https://nabp.pharmacy/news/news-releases/called-canadian-pharmacies-danger-consumers-nabp-reports/